The image analysis software on the automated microscopy system allows you to plot scattergrams using any size/shape parameter.

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Particle Characterization System - Morphologi G3

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Raman Microscopes

Malvern and Kaiser Optical Systems collaborate to develop an advanced range of Raman Microscopes

The Morphologi's image analysis software allows you to plot scattergrams using any size/shape parameter

Learn how the Morphologi's image analysis software allows you to plot scattergrams using any size/shape parameter

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Who is Kaiser Optical Systems Inc and what do they do?

Kaiser Optical Systems, Inc., a wholly owned subsidiary of Rockwell Collins (NYSE: COL), is a leader in the design and production of holographic optical elements, Raman analyzers and components for spectroscopy (www.kosi.com).

What is Raman spectroscopy and how is it used?

Raman spectroscopy is a well-accepted technique to measure chemical composition of inorganic and organic materials. A sample is illuminated with a laser and the scattered light is collected. The wavelengths and intensities of the scattered light provide a fingerprint by which the molecule chemical composition of the target particle can be identified.

What is the intended outcome of the collaboration for Malvern?

Malvern will integrate the Kaiser RamanRxn System™ analyzers and probes into our Morphologi® platform to enable its high performance automated image analysis to guide the collection of Raman data on a range of particulate and solid materials. There are a variety of applications in which it is critical to obtain the chemical ID of dispersed particles for example pharmaceutical, life science and forensic applications where sophisticated sample and particle handling, automated image recognition and chemical characterization combine to take Raman spectroscopy to a new level of intelligence and automation. As part of the process of bringing the resulting new products to market, we will be seeking the involvement of potential customers at the final stages of product development and for beta evaluations

Why do You need it?

Many Raman microscopes are heavily dependant on operator interaction and are not effectively combined with particle characterization. These new products will be differentiated through the unique combination of the Morphologi ® platforms capability to automatically locate, measure and classify particles together with Kaiser’s best in class Raman spectrometer and probe technology. This combination will provide novel approaches such as Intelligent mapping of drug particles, granules or aggregates and statistically robust data acquisition for tablet analysis.

A typical workflow for Morphologically Directed Raman Spectroscopy

1) SOP driven measurements eliminates user variability
2) Automatically classify particles based on their size and shape
3) Get Raman spectra, Chemical ID and library classification of selected particles
4) Morphologically Directed Raman Classification - API (red) and excipient (blue)