Analyzing Tablet Blend Morphology with NIR Chemical Imaging

More information:
	Blend uniformity
	Domain statistics calculation
	Contaminant and impurity identification
	Root cause analysis and out-of-spec determinations
	Bibliography


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	Analyzing Tablet Blend Morphology with NIR Chemical Imaging


	A NIR chemical image of a tablet shows the location and blend morphology of the active ingredient as well as all of the excipients. The image, collected in the near infrared spectral range, provides an intuitive understanding of the relationship between the components. Being far more than 'pretty pictures,' NIR chemical images reveal the extent of ingredient blending, domain size distributions, agglomeration of component particles, the presence of polymorphs and trace contaminants. The wealth of chemical and physical information in a chemical image provides a fingerprint of the tablet's production properties, and ultimately, its performance. Important attributes like dissolution can be radically altered by tablet morphology - the integrated physical and chemical associations of ingredients. As a result, millions of dollars are invested in optimizing tablet blend. Until NIR Chemical Imaging became available, existing analytical techniques were not able to access this information. The keys to unlocking these secrets are contained in the tablet itself, and analytical tools such as HPLC, destroyed that. Chemical imaging characterizes this critical piece of the puzzle - the spatial distribution of sample components.