Spraytec - Pharmaceutical spray applications

Already well-established for locally acting pharmaceuticals, Orally Inhaled and Nasal Drug Products (OINDPs) show great promise for the effective delivery of a variety of systemically-acting drug products. Patient acceptability, rapid absorption, gastro-intestinal tract avoidance, and the opportunity for product differentiation are just some of the driving factors.

For all OINDPs, particle size is a critical-to-quality attribute, directly influencing clinical efficacy. The correlation between particle size and in vivo deposition behavior makes particle size measurement essential for all inhaled products - in development, manufacture and QC. Spraytec meets this demand.

Spraytec is an advanced laser diffraction particle size analyzer designed specifically for spray droplet and dry powder aerosol  measurements. A robust system with SOP-driven operation it offers:

• Rapid data acquisition: measurement rates in excess of 2.5 kHz allow real-time monitoring of particle size changes during a spray event.
• A broad dynamic range: accurate particle size measurement from 0.1 to 2000 micron covers the sub-10 micron range of primary interest for pulmonary delivery, nasal sprays and the characterization of poorly dispersed agglomerates.
• Concentration measurement: in combination with size data, enables the dynamic study of dispersion behavior.

A powerful tool for rapid screening and accelerated optimization of OINDPs, Spraytec perfectly complements techniques such as cascade impaction, adding detailed insight into dispersion and atomization behavior. Such information promotes an efficient, knowledge-led approach to device and formulation development, as advocated by QbD.