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Although we’ve had the Zetasizer Nano only since November last year, it is clearly proving to be the easiest to use and most reliable of all the light scattering systems we’ve had in the lab. Whether sample concentration is low or high, it is never a problem, and is all taken care of with a single button, fully automated measurement. Data are clean and easy to interpret. Whereas light scattering systems we’ve used previously have proved too sensitive to contaminating particles, this is overcome with the Zetasizer Nano.read more

- Fred Hutchinson Cancer Research Center (SIC)

Zetasizer News - changes in specification Zetasizer Nano ZS - Specification Zetasizer Nano S - Specification Zetasizer Nano Z - Specification Zetasizer Nano ZS90 - Specification Zetasizer Nano S90 - Specification

Size measurement

Maximum particle size range (diameter): 0.3nm - 10µm**      
0.3nm - 5µm††      
Minimum sample volume: 12µL      
20µL    
Minimum sample concentration: 0.1mg/mL Lysozyme
0.1ppm polystyrene latex (60nm)
     
Maximum sample concentration: 40%w/v*
     
Size measurement in continuous flow for use as SEC chromatography detector : Flow rate maximum 1mL/min
     

Zeta potential measurement

         
Particle size range (diameter): 3.8nm - 100µm†    
Zeta potential range: No practical limits exist
   
Electrophoretic mobility range: Minimum Zero
No practical upper limit exists
   
Conductivity range: 0 to 200mS/cm    
Sample concentration range: Up to 40%w/v†    
Minimum sample volume: 750µL (Folded capillary cell)
750µL (Dip cell)
150µL (High concentration cell)
   

Molecular weight measurement

         
Absolute molecular weight range using Debye plot: 980Da - 2x107 Da†      
9,800Da - 2x107 Da†      
Molecular weight range estimated from Hydrodynamic diameter: 342Da - 2x107 Da†  
Minimum sample volume: 12µL      
20µL      
Minimum volume for automated measurement: 4mL      

Trend measurement

         
Standard: Size Vs Time or Temperature  
Zeta potential Vs Time or Temperature    
Using optional MPT-2 autotitrator: Size as a function of pH, conductivity or additive concentration      
Size as a function of pH, or additive concentration  
Zeta potential as a function of pH, conductivity or additive concentration

General specifications

         
Temperature range: 0ºC to 90ºC*
Condensation control: Purge facility using dry air.
Patents granted: NIBS
DE 19725211
US 6,016,195
JP 2,911,877
EP 0 884 580 designated GB, FR, AU, SW, BE
     
M3 "High & Low Frequency Electrophoresis"
GB 2,361,772
EP 1 154 266 designated DE, FR
US 09/843339
JP 2001-134510
   
Laser: 4mW He-Ne, 633nm
Laser attenuator : Automatic, transmission 100% to 0.0003%
Detector : Avalanche photodiode,Q.E > 50% at 633nm
 
Product laser class: Class 1 compliant, EN 60825-1:2001 and CDRH
Size : 320mm, 600mm, 260mm (W,D,H)
Weight : 21kg
Recommended computer specification: Pentium PC 2GHz, 128MByte RAM, 80MByte free hard disk space, 1024 x 768 screen resolution, CD-ROM drive, Windows XP Pro (Service pack 2 or higher) or VISTA Business or Ultimate. One free USB port.

Note. A laptop computer with a USB port can be used with all Zetasizer Nano systems and MPT-2 autotitrator.

Options

         
50mW 532nm laser as replacement for standard He-Ne Laser: For the measurement of samples not compatible with the standard 633nm He-Ne laser      
Narrow band filter: To improve signal quality for fluorescent samples
Advanced data processing software: Advanced system utilities and additional analysis algorithms
Regulatory compliance: 21 CFR part 11 operating mode software.
Extended temperature: Increase of temperature range to 0°C - 120°C

Site requirements

         
Power requirements: AC 100-240V, 50-60Hz, 100W
Ambient operating Temperature: 10ºC - 35ºC.
Humidity : 10 – 90% non-condensing.
Location: Normal laboratory conditions, out of direct sunlight.
Dry air for operation at temperatures below the dew point : DIN8573-1, oil class 1, water class 3, pressure 200+/-20kPag. Fitting M5 female thread to BS3643.

Note:

* Temperature accuracy, 0.1°C at 25°C, 0.2°C at 0°C and 0.5°C at 90°C, 1°C at 120°C

** Peak mode range (diameter), 0.6nm - 8.9 microns, sample dependent

† Sample dependent

†† Peak mode range (diameter), 0.6nm - 3 microns, sample dependent

 
 
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