Pharmaceutical process optimization is critical during new drug development
Pharmaceutical Industry Solutions

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Pharmaceutical Industry Overview

50 billion aspirin tablets are consumed worldwide each year
The US economy currently has net gains of an estimated $2.4 trillion per year due to increased life expectancy
70% of pharmaceutical drugs are consumed as powders in the form of tablets or capsules

Pharmaceutical drugs are used for the benefit of human and animal health. Innovators in pharmaceutical R&D of new drugs have not only controlled life threatening diseases and improved the quality of life and productivity, but have also increased the average life expectancy during the past few decades. The pharmaceutical industry is an important sector in the worldwide economy.

Around 70% of pharmaceutical drugs are consumed as the solid oral dosage type, that is tablets and capsules and the majority of the constituents of a dosage form are particulate in nature. These constituents are the Active Pharmaceutical Ingredients (APIs) and the excipients. The particle size properties of pharmaceutical APIs and excipients are very important characteristics for these solid oral dosage formulations. During formulation development stages, in vitro tests are used to determine the profiles of solid dosage forms. This allows assessment of the interactive effects of these properties on the bioavailabilty of the API in the human body, and helps predict therapeutic efficiency. In general, while large particle size helps optimize flow during the granulation process of solid dose forms, a smaller particle size of APIs contained in tablets or capsules is known to enhance dissolution and absorption.

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Requires free registration and loginOn-demand presentation: You bought PAT - Now what?
With frequent responsibility and personnel changes, pharmaceutical engineers occasionally find themselves in charge of implementing and integrating unfamiliar analytical technologies. This presentation will discuss the basic concepts of the on-line particle size analyzer Insitec, and its implementation; such as choosing a sampling location, assessing sampling representativity and optimizing the measurement. Also, we will briefly address data interpretation, and use for close loop control of continuous/semi-continuous proccess.
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Requires free registration and loginOn-demand presentation: Inline particle sizing for granulation processes – A PAT tool for the pharmaceutical industry
Granulation is an important unit operation for the pharmaceutical sector and is widely used to improve the flow properties and consistency of tableting blends, amongst other processing benefits. The Parsum probe IPP70 utilizes the technique of Spatial Filter Velocimetry and has proved to be a valuable tool in the pharmaceutical industry. The recently released pharma client software “Parsum view” for the Parsum IPP70 enables GMP-compliant data handling and storage with features such as audit trail, user access control, and safe data storage.
  Start the on-line presentation: Inline particle sizing for granulation processes – A PAT tool for the pharmaceutical industry

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