Within the past decade the vital role of exosomes and microvesicles as mediators of intercellular communication has been increasingly documented. Exosomes and microvesicles are involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes.
In addition, pathophysiological roles for exosomes and microvesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention.
Knowing the size and concentration of exosomes and microvesicles in their natural environment is of significant value in elucidating the role these structures play in diseases and the ways in which they may be exploited in diagnostic or therapeutic applications.
The ability of the NanoSight range of instruments to visualize, size, count exosomes and microvesicles as small as 30nm means it has become an indispensable technology in this field In addition, the technology has the ability to operate in fluorescence mode with a range of excitation wavelengths allowing visualization, sizing and concentration measurement of fluorescently labeled exosomes and microvesicles.