Liposomes are artificially prepared spherical vesicles composed of a lipid bilayer that are used in a wide range of industries, including the biopharmaceutical and consumer product sectors. However, recent applications for liposomes have focused on their suitability for use as drug delivery vehicles due to the ability to incorporate water-soluble materials in their aqueous volume or oil-soluble materials in the lipid bilayer.
Malvern’s range of easy to use particle size, zeta potential and rheological instrumentation can be used in the study of liposomes across a wide range of industries. Market leading Zetasizer, NanoSight and Archimedes systems combined with our industry and application knowledge can be used to:
- Characterize the particle size, charge and concentration of liposomes.
- Help predict the fate of the liposomes in vivo.
- Monitor the association of charged liposomes with oppositely charged molecules.
- Study the phase transition temperature of liposomes.
- Understand the influence of pH and other dispersant conditions on liposome charge using the optional MPT-2 autotitrator accessory.
- Study the encapsulation of liquid-liquid systems.
- Through the application of fluorescence labeling the ability to measure size and concentration of liposomes in biologically relevant fluids