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The small size of nanoparticles is of utmost importance in order for them to maintain their unique optical, electronic, thermal and chemical properties. Measuring their size is therefore critical to understanding these nano-scale materials.

Zeta potential is another important parameter that is related to nanoparticle stability or aggregation in a dispersion, and can have significant implications on product performance.

Light scattering, especially dynamic light scattering, and electrophoretic light scattering are now the standard techniques for measuring the size and zeta potential of dispersed nanoparticles. Two new techniques, Nanoparticle Tracking Analysis (NTA), and also Resonant Mass Measurement (RMM) can also be used for sizing nanoparticles as well as counting the number of particles present in a sample, and both are especially suited to polydisperse samples. Nanoparticle Tracking Analysis (NTA) is provided via the Malvern NanoSight range of instruments, and RMM is available via Archimedes.

Malvern offers a range of fast, reliable and simple to use systems that incorporate light scattering technology, resonant mass measurement or nanoparticle tracking analysis (NTA), which are used to:

  • Determine nanoparticle size.
  • Detect the formation of aggregates in a sample containing nanoparticles.
  • Measure zeta potential for an indication of nanoparticle stability.
  • Count the number of nanoparticles present in a sample.

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NTA Concentration Upgrade Webinar - Recorded (English)

An overview of the NTA Concentration Measurement upgrade which gives improved concentration data by further reducing the influence of user settings and allowing improved inter- and intra-laboratory comparison of concentration data.

NanoSight range,NanoSight NS300,NanoSight NS500
Date recorded:
June 18 2015

Keywords: Nanoparticles English DNA/RNA and oligonucleotides Liposomes and micelles Viruses and vaccines Webinar - Recorded Greenwich Time NanoSight range NanoSight NS500 NanoSight NS300 Exosomes and microvesicles Nanoparticle Tracking Analysis 

NTA Fluorescence mode Webinar - Recorded (English)

This short presentation will give an overview of fluorescence and what you need to think about before you start making measurements of fluorescent samples with NanoSight instruments.

NanoSight range
Date recorded:
June 18 2015

Keywords: Nanoparticles English DNA/RNA and oligonucleotides Liposomes and micelles Viruses and vaccines Webinar - Recorded Greenwich Time NanoSight range Exosomes and microvesicles Nanoparticle Tracking Analysis Fluorescence detection 

Experimental progress in high conductivity electrophoresis using the Diffusion Barrier Technique Poster (English)

In this work we demonstrate latex measurements up to 4M KCL using the Diffusion Barrier Technique, thereby demonstrating sample-limited, rather than instrument-limited characterization of high conductivity samples.

Keywords: Nanoparticles English Poster Particle size Zeta potential Dynamic Light Scattering Electrophoretic Light Scattering Colloids Zetasizer Nano ZS Proteins Zetasizer Nano ZSP Protein mobility 

NanoSight NTA Concentration Measurement Upgrade Application Note (English)

The inter- and intra- laboratory repeatability and reproducibility are greatly improved with the application of the NTA concentration measurement upgrade, which has also been shown to reduce the influence of user selected capture and analysis setti...

Keywords: Nanoparticles English Application Note Particle concentration Colloids Liposomes and micelles Viruses and vaccines Sub-visible particles Proteins Biological drug characterization and development Bioformulation development Antibodies and derivatives NanoSight NS500 NanoSight NS300 Nanotoxicology Exosomes and microvesicles Nanobubbles Nanoparticle Tracking Analysis 

NanoSight NTA Concentration Measurement Upgrade Technical Note (English)

NanoSight instruments with upgraded concentration measurement have increased concentration measurement accuracy and repeatability. This provides improved measurement robustness and removes the influence of user settings. Data is shown here that illus...

Keywords: Nanoparticles English Technical Note Particle concentration Particle size NanoSight range Nanoparticle Tracking Analysis 
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The Malvern NanoSight NTA system allows us to directly and reliably quantify extracellular vesicle yields from the cell lines under investigation, which is critical to this project.

Dr Paulaitis, Ohio State University, United States

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