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In addition to physical characteristics such as particle size and shape, the chemical identity of particulates can be important for a number of applications such as;

  • Component specific particle characterization for particle mixtures e.g. inhaled pharmaceutical medicines.
  • Identification of contaminant or outlier particles in production samples.
  • Forensic investigation of unknown particulate samples.

Malvern Instruments have developed advanced instrumentation for the chemical identification of particulate samples combining the high resolution size and shape information from automated imaging with the high chemical specificity of Raman spectroscopy.

Related products

Morphologi G3-ID Automated measurement of particle size, shape and chemical identity. Image
Measurement
Particle shape, Particle size, Chemical identification
Particle size range
1µm to 1000µm
Technology
Image analysis, Raman spectroscopy
More information
 
 

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Characterization of protein aggregates in suspension and on a filter membrane by Morphologically-Directed Raman Spectroscopy Application Note (English)

The combination of static microscopy and Raman spectroscopy in the Morphologi G3-ID enables automated chemical identification of protein aggregates and other contaminants in a biotherapeutic sample, either in suspension via a thin-path wet cell or on...



Discriminating between polymorphs of acetaminophen using Morphologically-Directed Raman Spectroscopy (MDRS) Application Note (English)

Polymorphic conversions are an ongoing problem in the pharmaceutical industry.  Here we describe the use of Morphologically-Directed Raman Spectroscopy to distinguish and quantify particles of different polymorphic types of acetaminophen (paracetamol...



Achieving Bioequivalence in Generic Formulations by Characterizing Particle Size, Shape & Chemical Identity Webinar - Recorded (English)

The development of generic products involves the use of a variety of particle characterization techniques including traditional approaches such as laser diffraction and novel technologies such as Morphology Directed Raman Spectroscopy (MDRS). In thi...

Date recorded:
June 10 2015
Language:
English

Keywords: English Chemical identification Particle shape Particle size Webinar - Recorded Eastern Time 

Forensic Analyses by Morphologically Directed Raman Spectroscopy Webinar - Recorded (English)

Morphologically Directed Raman Spectroscopy (MDRS) can be applied to a variety of forensic evidence types, such as illicit drugs, counterfeit pharmaceuticals, hoax powders, soils and gunshot residues. It is a novel and reliable tool that would enable...

Product:
Morphologi G3-ID
Date recorded:
May 28 2015
Language:
English

Keywords: English Chemical identification Webinar - Recorded Eastern Time Morphologi G3-ID 

Accelerating the Development of Generic Pharmaceuticals: Developing an Analytical Toolkit Suitable for De-formulating Complex Reference Products Article (English)

In its report ‘Critical Path Opportunities for Generic Drugs’, the FDA emphasizes the need for advances in the field of analytical sciences in order to accelerate the development of generic products. Here, Paul Kippax highlights techniques that are e...


Keywords: Development English Article Chemical identification Particle shape Particle size Gel Permeation Chromatography Image analysis Raman spectroscopy Size Exclusion Chromatography Pharmaceutical formulation and development Morphologi G3-ID 
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