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In addition to physical characteristics such as particle size and shape, the chemical identity of particulates can be important for a number of applications such as;

  • Component specific particle characterization for particle mixtures e.g. inhaled pharmaceutical medicines.
  • Identification of contaminant or outlier particles in production samples.
  • Forensic investigation of unknown particulate samples.

Malvern Instruments have developed advanced instrumentation for the chemical identification of particulate samples combining the high resolution size and shape information from automated imaging with the high chemical specificity of Raman spectroscopy.

Related products

Morphologi G3-ID Automated measurement of particle size, shape and chemical identity. Image
Particle shape, Particle size, Chemical identification
Particle size range
1µm to 1000µm
Image analysis, Raman spectroscopy
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Improved approaches for particulate characterization in biotherapeutics Webinar - Recorded (English)

Product quality and safety concerns have driven the enumeration of particulate species in injectable products. Guidelines, such as USP<787>, <788>, and <790>, describe methods for collecting accurate particle count and size data in...

Morphologi range
Date recorded:
July 30 2015

Exploring the effect of carbon microstructure on lithium-ion battery performance Application Note (English)

This application note describes the combined use of static optical microscopy and Raman spectroscopy in the Morphologi G3-ID to assess the various morphological classes of carbon for use in lithium-ion battery manufacture.  High levels of crystallini...

Characterization of protein aggregates in suspension and on a filter membrane by Morphologically-Directed Raman Spectroscopy Application Note (English)

The combination of static microscopy and Raman spectroscopy in the Morphologi G3-ID enables automated chemical identification of protein aggregates and other contaminants in a biotherapeutic sample, either in suspension via a thin-path wet cell or on...

Discriminating between polymorphs of acetaminophen using Morphologically-Directed Raman Spectroscopy (MDRS) Application Note (English)

Polymorphic conversions are an ongoing problem in the pharmaceutical industry.  Here we describe the use of Morphologically-Directed Raman Spectroscopy to distinguish and quantify particles of different polymorphic types of acetaminophen (paracetamol...

Achieving Bioequivalence in Generic Formulations by Characterizing Particle Size, Shape & Chemical Identity Webinar - Recorded (English)

The development of generic products involves the use of a variety of particle characterization techniques including traditional approaches such as laser diffraction and novel technologies such as Morphology Directed Raman Spectroscopy (MDRS). In thi...

Date recorded:
June 10 2015

Keywords: English Chemical identification Particle shape Particle size Webinar - Recorded Eastern Time 
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