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In addition to physical characteristics such as particle size and shape, the chemical identity of particulates can be important for a number of applications such as;

  • Component specific particle characterization for particle mixtures e.g. inhaled pharmaceutical medicines.
  • Identification of contaminant or outlier particles in production samples.
  • Forensic investigation of unknown particulate samples.

Malvern Instruments have developed advanced instrumentation for the chemical identification of particulate samples combining the high resolution size and shape information from automated imaging with the high chemical specificity of Raman spectroscopy.

Related products

Morphologi G3-ID Automated measurement of particle size, shape and chemical identity. Image
Measurement
Particle shape, Particle size, Chemical identification
Particle size range
1µm to 1000µm
Technology
Image analysis, Raman spectroscopy
More information
 
 

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Detective work Article (English)

Particle agglomeration can compromise the clinical efficacy of pharmaceutical products and must therefore be closely controlled. This article provides practical guidance on using automated imaging for efficient agglomerate detection.


Keywords: QA/QC and routine testing Development Aerosols and sprays Powders and granules Suspensions, slurries and pastes English Article Chemical identification Particle shape Particle size Image analysis Raman spectroscopy Pharmaceutical formulation and development Pharmaceutical manufacturing Excipients and coatings Morphologi range 

Accelerating the Development of Generic Pharmaceuticals: Developing an Analytical Toolkit Suitable for De-formulating Complex Reference Products Article (English)

In its report ‘Critical Path Opportunities for Generic Drugs’, the FDA emphasizes the need for advances in the field of analytical sciences in order to accelerate the development of generic products. Here, Paul Kippax highlights techniques that are e...


Keywords: Development English Article Chemical identification Molecular weight Particle shape Particle size Gel Permeation Chromatography Image analysis Raman spectroscopy Size Exclusion Chromatography Pharmaceutical formulation and development 

Forensic analysis of an artificial sweetener commonly employed in hoax powder attacks using Morphologically Directed Raman spectroscopy Application Note (English)

This application note details how Morphologically Directed Raman Spectroscopy (MDRS) using the Morphologi G3-ID can be applied to the forensic identification of commercially sourced white powders commonly used in hoax bio-terrorism powder attacks. It...


Keywords: Root cause analysis (troubleshooting) Powders and granules English Application Note Chemical identification Particle shape Particle size Image analysis Raman spectroscopy Morphologi G3-ID 

Accelerating the deformulation workflow for oral solid dosage forms Whitepaper (English)

Oral Solid Dosage (OSD) forms still represent a significant share of the pharmaceutical market. As a result, they remain an important target for generic product developers. In this white paper we introduce a workflow for OSD product deformulation and...


Keywords: Development English Whitepaper Chemical identification Particle shape Particle size Image analysis Raman spectroscopy Pharmaceutical formulation and development Oral solid dose Morphologi G3-ID 

Pharmaceuticals - When size is not enough Webinar - Recorded (English)

Particle size has been recognized as a key parameter in the development and manufacture of a wide range of pharmaceutical materials. Sometimes, however, size analysis is just not enough to provide the answer to a specific application issue. This pres...

Date recorded:
October 1 2014
Language:
English

Keywords: English Chemical identification Particle shape Particle size Webinar - Recorded Eastern Time Drug discovery Pharmaceutical chemical development Pharmaceutical formulation and development Pharmaceutical manufacturing 
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