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Rheology is the study of flow and deformation of materials. Rheological properties, such as viscosity and viscoelasticity, can be measured from bulk sample deformation using a mechanical rheometer, or on a micro-scale using an optical technique such as Microrheology.

Microrheology involves tracking the motion of dispersed tracer particles of known size by Dynamic Light Scattering (DLS) and determining the rheological properties of the sample using the Generalized Stokes-Einstein Relation. DLS Microrheology is a passive microrheology technique, whereby the colloidal probe particles only undergo thermal fluctuations in a system at thermodynamic equilibrium.

DLS Microrheology is applicable for the rheological characterization of low viscosity and weakly-structured complex fluids, such as dilute solutions of polymers and surfactants through to concentrated protein formulations. For these types of materials, Microrheology offers significant advantages:

  • Probes very high frequencies necessary for characterizing inherent short timescale, viscoelastic responses (whereas mechanical techniques are fundamentally limited by inertia).
  • Only requires microliter-scale volumes for rheological characterization of materials where sample volume is limited e.g. protein-based formulations.

Applications of DLS Microrheology include:

  • Rheological characterization of therapeutic proteins and biopolymer solutions.
  • Viscoelastic measurements of protein solutions to assess onset of protein-protein interactions and insoluble aggregate formation
  • Formulation development and screening.
  • High frequency rheology of dilute systems on process-relevant timescales.
  • Monitoring structure development in complex fluids with time or temperature, or structure breakdown on dilution.

Related products

Zetasizer Nano ZSP Sensitivity, simplicity, versatility Image
Measurement
Molecular size, Particle size, Molecular weight, Zeta potential, Protein mobility, Microrheology
Particle size range
0.0003µm to 10µm
Temperature range
90°C
Dispersion type
Wet
Technology
Dynamic Light Scattering, Electrophoretic Light Scattering, Static Light Scattering
More information
Zetasizer Nano ZS Performance, simplicity, versatility. Image
Measurement
Molecular size, Molecular weight, Particle size, Zeta potential
Temperature range
90°C
Particle size range
0.0003µm to 10µm
Dispersion type
Wet
Technology
Dynamic Light Scattering, Electrophoretic Light Scattering, Static Light Scattering
More information
 
 

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Polymer solution characterization – Part 4 Webinar - Live (English)

Polymeric materials are the most studied of all rheological materials and polymeric solutions in particular are perhaps the most interesting. They are ubiquitous in every-day life and play an important role in applications ranging from jo...

Date:
September 16 2014
Language:
English

Keywords: English Rheology and viscosity Rheometry - capillary Rheometry - rotational Polymers, plastics and rubbers Webinar - Live Eastern Time Microrheology Rheometry - microfluidic flow 

Microrheology: Running measurements on the Zetasizer ZSP/ZS Technical Note (English)

DLS microrheology measurements are particularly suited to the measurement of low viscosity and weakly-structured materials, such as polymer and biopolymer solutions.This technical note gives guidance about how to make a microrheology measurement and ...


Keywords: Polymer solutions English Method development Technical Note Electrophoretic Light Scattering Zetasizer Nano ZS Proteins Zetasizer Nano ZSP Microrheology 

DLS Microrheology on the Zetasizer Nano ZSP/ZS: Use of a zeta potential pre-measurement step to assess tracer particle-sample interactions Application Note (English)

This technical note describes the practical aspects to consider when making a microrheology measurement by dynamic light scattering, and how zeta potential can be used as an indicator of the interaction between tracer particle and sample.


Keywords: English Method development Application Note Zeta potential Electrophoretic Light Scattering Zetasizer Nano ZS Proteins Zetasizer Nano ZSP Microrheology 

Probing low viscosity and weakly-structured complex fluid formulations using DLS microrheology Webinar - Recorded (English)

This webinar is of interest to anyone involved in the rheological testing of complex fluid formulations which are low viscosity and weakly-structured. DLS microrheology is a technique which is particularly applicable to polymers and prote...

Product:
Zetasizer Nano ZSP
Date recorded:
May 27 2014
Language:
English

Keywords: English Rheology and viscosity Dynamic Light Scattering Webinar - Recorded Eastern Time Zetasizer Nano ZSP Microrheology 

Light scattering techniques support formulation development Article (English)

Researchers at Novozymes pharma and Malvern Instruments show how light scattering techniques benefit the study of the stability of human albumins. The studies involve the new Zetasizer ZSP and APS, Viscotek SEC systems, and the Morphology G3-ID


Keywords: English Article Morphologi G3 Chemical identification Molecular size Molecular weight Zeta potential Dynamic Light Scattering Electrophoretic Light Scattering Gel Permeation Chromatography Raman spectroscopy Size Exclusion Chromatography Zetasizer APS Proteins Zetasizer Nano ZSP Microrheology Bioformulation development Viscotek systems Viscotek detectors Morphologi G3-ID 
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Polymer solution characterization – Part 4
(September 16 2014)

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