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The physical and even the chemical properties of a polymer in a final manufactured product can be closely related to the polymer structure.

Types of polymer structure:

  • Linear
  • Random branched
  • Comb structure
  • Starburst polymers or dendrimers
  • Copolymers
  • Cross-linked

Multi-detector SEC, such as the TDA, can be used to determine a number of the factors that determine structure:

  • Branching ratio
  • Branching frequency
  • Molecular density / Intrinsic Viscosity
  • Copolymer composition
  • Backbone modification

Structure is determined using a combination of an intrinsic viscosity detector that is sensitive to density, and a light scattering detector that provides molecular weight. These parameters are used to construct a Mark – Houwink plot from which a range of structural information can be deduced.

Application example:
Acrylonitrile-butadiene copolymers, commonly called nitrile rubbers (NBR), are used widely for adhesive compounding, and gloves used for examination and cleaning.

The composition of the copolymers, the polymer cross-linking and branching as well as the molecular weight of NBR affect the macroscopic properties of NBR such as flexibility and puncture resistance.

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Key considerations when purchasing an advanced GPC/SEC system Whitepaper (English)

Investing in a new GPC/SEC system is a big decision with many factors to consider. This white paper lists the key items that you should think about when buying a new system and discusses the reasons for their importance.  Finally, it discusses what M...



Optimizing drug delivery polymer conjugate levels using Advanced Multi-Detector GPC Application Note (English)

The drug delivery polymer polyglutamic acid was conjugated with different amounts of Doxorubicin and characterized using advanced multi-detector GPC to measure drug content, molecular weight and structure



Fast, easy and reliable – Flow Injection Polymer Analysis for QA/QC and Process Control Webinar - Recorded (English)

Gel Permeation Chromatography (GPC) also known as Size Exclusion Chromatography (SEC), is a very popular analytical tool for characterizing the molecular weight and structure of natural and synthetic polymers. Such information is important for both r...

Product:
OMNISEC
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April 14 2016
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How Size Exclusion Chromatography can improve processes and quality in biopharmaceutical development Webinar - Recorded (English)

Size Exclusion Chromatography (SEC) is a valuable technique for the analysis of macromolecules such as proteins, antibodies, and polysaccharides. Characterization of these materials is essential for many applications, ranging from pharmaceutical/biop...

Product:
OMNISEC
Date recorded:
March 1 2016
Language:
English


General Instrument Care of the Viscotek TDAmax GPC/SEC system Technical Note (English)

This technical note details information about maintaining Viscotek GPC/SEC systems to maximize reliability, prevent damage, reduce downtime, recognise imminent issues and minimise service visits


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