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The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.

Understanding this and other molecular parameters is key to controlling product performance in a wide variety of applications areas including:

  • Strength, durability and toughness of plastics and other synthetic polymers.
  • Degradation and release rate of drug delivery polymers.
  • Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives.
  • Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives.
  • Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs).

Malvern’s advanced GPC/SEC detectors, which include low angle and right angle light scattering (LALS and RALS) and multi-angle light scattering (SEC-MALS), are designed to measure absolute molecular weight with unparalleled accuracy. Complete systems such as the TDAmax form and out-of the-box solution, while add-on detectors such as the SEC-MALS 20 and the Zetasizer µV allow you to upgrade an existing GPC/SEC system to measure absolute molecular weight.

Related products

Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Accuracy
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
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Zetasizer range The worlds most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Image
Measurement
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
Particle size range
Dispersion type
Wet
Technology
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
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PEGylated proteins: Optimizing conjugation reactions using triple detection SEC Application Note (English)

In this application note, interferon α-5 was conjugated with two different PEG molecules in different reactions. The individual protein and PEG molecules, as well as the PEGylated conjugates are characterized by SEC and their composition, mol...


Keywords: English Application Note Molecular size Molecular weight Static Light Scattering Size Exclusion Chromatography Protein aggregation Proteins Biological drug characterization and development Viscotek TDAmax Viscotek SEC-MALS Viscotek UV-PDA Detector (2600) 

The Science of Beauty - Characterizing Hyaluronic Acid - the molecule behind anti-aging creams Webinar - Recorded (English)

Hyaluronic acid (HA) is a natural polysaccharide, that plays an important role in tissues, such as skin, tendons, muscles, and cartilage. As well as medical applications, It finds wide-spread use in cosmetics, particularly skin creams. In...

Date recorded:
June 25 2014
Language:
English

Keywords: English Molecular size Molecular weight Cosmetics Personal care Polymers, plastics and rubbers Webinar - Recorded Eastern Time 

Overcoming the negative effect of protein structure on molecular weight measurement by Size Exclusion Chromatography – Two protein case studies with Anthrolysin and Bcl-2 Application Note (English)

A description of how advanced GPC/SEC detection can overcome inaccuracy in the measurement of molecular weight caused by deviation in the structure of the sample protein from that of the protein standards or interaction with the chromatography column...


Keywords: English Application Note Viscotek range Molecular structure Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Viruses and vaccines Protein aggregation Proteins 

Polymer solution characterization - Part 1. "Absolute" molecular weight - fact or fiction? Webinar - Recorded (English)

The measurement of the "absolute" molecular weight (or molar mass) of polymers and proteins is often mentioned and referenced but what does it mean? This talk will present a summary of the solution techniques available for measurement of ...

Date recorded:
April 10 2014
Language:
English

Keywords: Polymer solutions English Molecular weight Bulk (commodity) polymers Engineering polymers Rubbers and elastomers Polymers from renewable sources Specialty and novel polymers Polymer recycling Webinar - Recorded Eastern Time Polyolefins 

Ensuring Accurate and Repeatable measurement of proteins using the Zetasizer APS Application Note (English)

In this application note, well known protein samples were used in a cross-contamination test to investigate the accuracy and repeatability of the Zetasizer APS dynamic light scattering (DLS) system.


Keywords: English Application Note Molecular size Molecular weight Dynamic Light Scattering Zetasizer APS Proteins Bioformulation development Biopharmaceutical manufacturing Peptides 
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