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The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.

Understanding this and other molecular parameters is key to controlling product performance in a wide variety of applications areas including:

  • Strength, durability and toughness of plastics and other synthetic polymers.
  • Degradation and release rate of drug delivery polymers.
  • Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives.
  • Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives.
  • Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs).

Malvern’s advanced GPC/SEC detectors, which include low angle and right angle light scattering (LALS and RALS) and multi-angle light scattering (SEC-MALS), are designed to measure absolute molecular weight with unparalleled accuracy. Complete systems such as the TDAmax form and out-of the-box solution, while add-on detectors such as the SEC-MALS 20 and the Zetasizer µV allow you to upgrade an existing GPC/SEC system to measure absolute molecular weight.

Related products

OMNISEC The world’s most advanced multi-detector GPC/SEC system molecular weight, molecular size, molecular structure, intrinsic viscosity by size exclusion chromatography with OMNISEC
Measurement
Molecular weight, Molecular size, Molecular structure
Molecular weight range
200Da to 10MDa
Minimum sample mass (polystyrene)
100ng
Minimum sample mass (BSA)
100ng
Technology
Size Exclusion Chromatography, Static Light Scattering, Gel Permeation Chromatography
More information
Viscotek SEC-MALS More angles, more data, more choice! Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation
Molecular weight range
1000Da to 10MDa
Minimum sample mass (polystyrene)
1µg
Minimum sample mass (BSA)
2µg
Technology
Gel Permeation Chromatography, Size Exclusion Chromatography, Static Light Scattering
More information
Viscotek range The leading multi-detector GPC/SEC systems and detectors. molecular weight, molecular size, molecular structure, intrinsic viscosity by gel permeation chromatography with Viscotek
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Molecular weight range
1000Da to 10MDa
Minimum sample mass (polystyrene)
1µg
Minimum sample mass (BSA)
1µg
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Measurement
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.3nm to 2µm
Dispersion type
Wet
Technology
Size Exclusion Chromatography, Dynamic Light Scattering
More information
 
 

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How low can you go? New advances in the analysis of low molecular weight polymers by GPC/SEC Webinar - Recorded (English)

Gel Permeation Chromatography (GPC) also known as Size Exclusion Chromatography (SEC), is a very popular analytical tool for polymer characterization. Low molecular weight polymers such as polyols, epoxies and polycaprolactones (amongst others) are u...

Product:
OMNISEC
Date recorded:
August 25 2015
Language:
English


From 0 to 60 – Novel polymer applications in the automotive industry Webinar - Live (English)

There is a strong global trend in automotive design that features a continuous increase in the use of conventional, performance, and novel polymeric materials. This is a result of weight savings, design flexibility, and ease of fabrication offered by...

Date:
September 3 2015
Language:
English


Characterization of IgG monomers & their aggregates Application Note (English)

Two antibody samples were characterized using column calibration and multi-detection SEC, and the results compared to show how multi-detection SEC provides more accurate data and a more complete characterization of the protein mixtures under study.



The Mark–Houwink plot – Differentiation of Branching and Composition Application Note (English)

Using OMNISEC, we will show how to separate the effects of a structural difference induced by a compositional change to a polymer (e.g. substitution) and the structural change induced by polymer chain branching.


Keywords: English Application Note Molecular structure Molecular size Molecular weight OMNISEC 

GPC/SEC analysis of polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA) using OMNISEC Application Note (English)

In this application note, a selection of different PLA and PLGA polymer samples were analyzed on Malvern's OMNISEC GPC/SEC system, which combines multiple detectors to provide information about structure and solution properties.


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