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The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.

Understanding this and other molecular parameters is key to controlling product performance in a wide variety of applications areas including:

  • Strength, durability and toughness of plastics and other synthetic polymers.
  • Degradation and release rate of drug delivery polymers.
  • Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives.
  • Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives.
  • Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs).

Malvern’s advanced GPC/SEC detectors, which include low angle and right angle light scattering (LALS and RALS) and multi-angle light scattering (SEC-MALS), are designed to measure absolute molecular weight with unparalleled accuracy. Complete systems such as the TDAmax form and out-of the-box solution, while add-on detectors such as the SEC-MALS 20 and the Zetasizer µV allow you to upgrade an existing GPC/SEC system to measure absolute molecular weight.

Related products

OMNISEC The world’s most advanced multi-detector GPC/SEC system Image
Measurement
Molecular weight, Molecular size, Molecular structure
Temperature range
20°C to 65°C
Technology
Size Exclusion Chromatography, Static Light Scattering, Gel Permeation Chromatography
More information
Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Temperature range
25°C to 160°C
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
Zetasizer range The worlds most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Image
Measurement
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
90°C
Particle size range
0.3nm to 10µm
Dispersion type
Wet
Technology
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
More information
 
 

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Anaysis of PLGA Molecular Weight and Structure by the latest Adavanced Multi-Detector GPC Systems Poster (English)

Different samples of commercially available PLGA were analyzed to compare their absolute molecular weight from light scattering to those quoted with the product. Additionally, the Mark-Houwink plots of different examples containing different ratios o...


Keywords: Polymer solutions English Poster Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography OMNISEC 

Characterizing polymers: Techniques for the measurement of molecular weight, molecular size and branching. Whitepaper (English)

A review of the methods available for measuring the key characteristics of polymers focusing on the benefits and value of gel permeation/size exclusion chromatography (GPC/SEC). Much of the paper talks exclusively about polymers, however many of the ...


Keywords: Polymer solutions English Whitepaper Zetasizer range Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Polymers, plastics and rubbers Adhesives and sealants Paints, inks and coatings Food additives Polysaccharides OMNISEC 

Compositional insights for protein mixtures: a case study of a semi-pure β-amylase extract Application Note (English)

In this application note, we describe the analysis of a semi-purified protein mixture containing β-amylase.  Step-by-step, we show how different properties of the proteins elicit a specific response in each detector and how the coupling this data can...


Keywords: English Application Note Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Protein aggregation Proteins Biopharmaceutical development OMNISEC 

Unsurpassed protein SEC using the latest innovation in advanced detection, OMNISEC Webinar - Recorded (English)

During this webinar, we introduces the latest innovations in SEC technology, and discuss how the new OMNISEC system will assist your protein characterization challenges. Focusing on applications, the webinar compares the capabilities of the system wi...

Product:
OMNISEC
Date recorded:
April 22 2015
Language:
English

Keywords: English Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Webinar - Recorded Eastern Time Protein aggregation Proteins Protein mobility OMNISEC Protein stability 

Structural elucidation of dextrans and other polysaccharides using OMNISEC Multi-Detection GPC Application Note (English)

A series of dextran samples ranging in molecular weight from about 1– 650 kDa are characterized using OMNISEC. Structural comparisons to other polysaccharides, gum arabic and pectin are presented


Keywords: Polymer solutions English Application Note Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Polymers from renewable sources Polysaccharides OMNISEC 
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