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The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.
Understanding this and other molecular parameters is key to controlling product performance in a wide variety of applications areas including:
Malvern’s advanced GPC/SEC detectors, which include low angle and right angle light scattering (LALS and RALS) and multi-angle light scattering (SEC-MALS), are designed to measure absolute molecular weight with unparalleled accuracy. Complete systems such as the TDAmax form and out-of the-box solution, while add-on detectors such as the SEC-MALS 20 and the Zetasizer µV allow you to upgrade an existing GPC/SEC system to measure absolute molecular weight.
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Here we describe the features and benefits of the OMNISEC GPC/SEC system and explain how OMNISEC sets a new standard in molecular characterization.
GPC/SEC is mainly used for the characterization of macromolecules including synthetic and natural polymers (including polysaccharides) as well as proteins or RNA/DNA. This white paper provides an introduction to the technique in 30 minutes.
PLA, PLGA and their copolymers are biocompatible, biodegradable and used in a number of medical applications. However, analysis of this low molecular weight and low dn/dc sample pushes the sensitivity boundaries of all previous light scattering detec...
The properties of polymeric excipients can directly affect the clinical efficacy, safety, and quality of a finished pharmaceutical product and are routinely identified as critical quality attributes (CQAs). This article looks at how gel permeation/si...
Four different polymers are analyzed by GPC/SEC to investigate the effect of molecular weight, dispersity and molecular structure on the final properties of the polymer.
(Webinar - Recorded)
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