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The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.

Understanding this and other molecular parameters is key to controlling product performance in a wide variety of applications areas including:

  • Strength, durability and toughness of plastics and other synthetic polymers.
  • Degradation and release rate of drug delivery polymers.
  • Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives.
  • Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives.
  • Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs).

Malvern’s advanced GPC/SEC detectors, which include low angle and right angle light scattering (LALS and RALS) and multi-angle light scattering (SEC-MALS), are designed to measure absolute molecular weight with unparalleled accuracy. Complete systems such as the TDAmax form and out-of the-box solution, while add-on detectors such as the SEC-MALS 20 and the Zetasizer µV allow you to upgrade an existing GPC/SEC system to measure absolute molecular weight.

Related products

Zetasizer range The world's most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Zetasizer range - particle size, dynamic light scattering, zeta potential, protein aggregation
Measurement
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
90°C
Particle size range
0.3nm to 10µm
Dispersion type
Wet
Technology
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
More information
OMNISEC The world’s most advanced multi-detector GPC/SEC system molecular weight, molecular size, molecular structure, intrinsic viscosity by size exclusion chromatography with OMNISEC
Measurement
Molecular weight, Molecular size, Molecular structure
Molecular weight range
200Da to 10MDa
Minimum sample mass (polystyrene)
100ng
Minimum sample mass (BSA)
100ng
Technology
Size Exclusion Chromatography, Static Light Scattering, Gel Permeation Chromatography
More information
Viscotek range The leading multi-detector GPC/SEC systems and detectors. molecular weight, molecular size, molecular structure, intrinsic viscosity by gel permeation chromatography with Viscotek
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Molecular weight range
1000Da to 10MDa
Minimum sample mass (polystyrene)
1µg
Minimum sample mass (BSA)
1µg
Technology
Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
 
 

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OMNISEC: Demo at your desk Webinar - Live (English)

Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a very popular analytical technique for characterizing natural and synthetic polymers. Malvern offers a range of multi-detector GPC systems for the advanced ch...

Product:
OMNISEC
Date:
September 29 2016
Language:
English


How multi-detector GPC/SEC can advance our understanding of drug delivery polymers Webinar - Live (English)

Correctly targeting a drug product’s delivery location and defining its release profile are critical challenges and the subject of a great deal of research. The role of polymers in drug delivery applications is growing, with particular emphasis on t...

Product:
Viscotek range,OMNISEC,Zetasizer range
Date:
September 6 2016
Language:
English


What is the Derived Count Rate? FAQ

The derived count rate is the normalized count rate taking into account the attenuation factor used



Fast, easy and reliable – Flow Injection Polymer Analysis for QA/QC and Process Control Webinar - Recorded (English)

Gel Permeation Chromatography (GPC) also known as Size Exclusion Chromatography (SEC), is a very popular analytical tool for characterizing the molecular weight and structure of natural and synthetic polymers. Such information is important for both r...

Product:
OMNISEC
Date recorded:
April 14 2016
Language:
English


Characterizing Polymeric Gelling Agents using Gel Permeation Chromatography. Are You Gelling? Webinar - Recorded (English)

Gel Permeation Chromatography (GPC), is a very popular analytical tool for polymer characterization. Key industries where GPC is used include the food and drink, paper, and personal care industries, among others, where polysaccharides such as cellulo...

Product:
OMNISEC
Date recorded:
March 10 2016
Language:
English

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Upcoming webinar

How multi-detector GPC/SEC can advance our understanding of drug delivery polymers
(September 6 2016)

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