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The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.

Understanding this and other molecular parameters is key to controlling product performance in a wide variety of applications areas including:

  • Strength, durability and toughness of plastics and other synthetic polymers.
  • Degradation and release rate of drug delivery polymers.
  • Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives.
  • Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives.
  • Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs).

Malvern’s advanced GPC/SEC detectors, which include low angle and right angle light scattering (LALS and RALS) and multi-angle light scattering (SEC-MALS), are designed to measure absolute molecular weight with unparalleled accuracy. Complete systems such as the TDAmax form and out-of the-box solution, while add-on detectors such as the SEC-MALS 20 and the Zetasizer µV allow you to upgrade an existing GPC/SEC system to measure absolute molecular weight.

Related products

Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Temperature range
25°C to 160°C
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
Zetasizer range The worlds most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Image
Measurement
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
90°C
Particle size range
0.3nm to 10µm
Dispersion type
Wet
Technology
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
More information
 
 

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OMNISEC live launch (9am UK) Webinar - Live (English)

Join our live launch event January 27 where we introduce the world’s most advanced SEC system - OMNISEC. Find out how OMNISEC will help you… Synthetic Polymers Monitor improvement in product performance when changing polymer components Investig...

Product:
Viscotek range
Date:
January 27 2015
Language:
English

Keywords: English Viscotek range Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Polymers, plastics and rubbers Webinar - Live Greenwich Time Biopharmaceutical development 

OMNISEC live launch (10:30 US EST) Webinar - Live (English)

Join our live launch event January 27 where we introduce the world’s most advanced SEC system - OMNISEC. Find out how OMNISEC will help you… Synthetic Polymers Monitor improvement in product performance when changing polymer components Investig...

Product:
Viscotek range
Date:
January 27 2015
Language:
English

Keywords: English Viscotek range Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Polymers, plastics and rubbers Webinar - Live Eastern Time Biopharmaceutical development 

GPC Characterization of Nylon using Formic Acid for Reduced Cost per Analysis Application Note (English)

GPC/SEC can be used to characterize commodity or bulk manufactured polymers. Here we describe how the use of formic acid instead of HFIP as the dissolution solvent and/or mobile phase can lead to improvements in both cost per analysis and health and ...


Keywords: Polymer solutions English Method development Application Note Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Bulk (commodity) polymers Viscotek 270max Viscotek TDAmax Viscotek TDA 305 

Exploring the role of SEC-MALS in protein and polymer characterization Webinar - Recorded (English)

Size exclusion chromatography (SEC) is a chromatographic technique for the characterization of proteins and biopharmaceuticals, as well as natural and synthetic polymers. Traditional systems comprised a single concentration detector (Conventional Cal...

Product:
Viscotek SEC-MALS,Viscotek 270max,Viscotek TDAmax,Viscotek RImax
Date recorded:
October 17 2014
Language:
English

Keywords: Polymer solutions English Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Food additives Rubbers and elastomers Specialty and novel polymers Membrane proteins Polysaccharides Webinar - Recorded GMT Time Protein aggregation Proteins Bioformulation development Antibodies and derivatives Viscotek 270max Viscotek RImax Viscotek TDAmax Viscotek SEC-MALS 

Powerful protein SEC made simple! Webinar - Recorded (English)

This webinar discusses how Malvern’s protein SEC measurement capabilities within the Viscotek range have developed and improved in the last year. We also introduce the new features that are included in the latest release of OmniSEC, including: Bio...

Product:
Viscotek range,Viscotek RImax,Viscotek DSV,Viscotek 270max,Viscotek TDAmax,Viscotek SEC-MALS
Date recorded:
September 30 2014
Language:
English

Keywords: English Viscotek range Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Webinar - Recorded Eastern Time Protein aggregation Proteins Biopharmaceutical development Viscotek 270max Viscotek DSV Viscotek RImax Viscotek TDAmax Viscotek SEC-MALS 
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OMNISEC live launch (9am UK)
(January 27 2015)

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