The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.
Understanding this and other molecular parameters is key to controlling product performance in a wide variety of applications areas including:
- Strength, durability and toughness of plastics and other synthetic polymers.
- Degradation and release rate of drug delivery polymers.
- Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives.
- Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives.
- Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs).
Malvern’s advanced GPC/SEC detectors, which include low angle and right angle light scattering (LALS and RALS) and multi-angle light scattering (SEC-MALS), are designed to measure absolute molecular weight with unparalleled accuracy. Complete systems such as the TDAmax form and out-of the-box solution, while add-on detectors such as the SEC-MALS 20 and the Zetasizer µV allow you to upgrade an existing GPC/SEC system to measure absolute molecular weight.