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By far the most important physical property of particulate samples is particle size. Measurement of particle size distributions is routinely carried out across a wide range of industries and is often a critical parameter in the manufacture of many products.
Measuring particle size distributions and understanding how they affect your products and processes can be critical to the success of many manufacturing businesses. Malvern Instruments offers leading instrumentation for all types of particle size analysis and characterization from sub-nanometer to millimeters in particle size.
Use the table below to help choose the right technology and particle size instrument for your needs:
Taylor Dispersion Analysis
0.2nm to >20nm
Dynamic Light Scattering
<1nm to >1µm
Nanoparticle Tracking Analysis
<30nm to >1µm
Resonant Mass Measurement**
50nm to 5µm
<100nm to >2mm
Spatial Filter Velocimetry
<50µm to 6mm
<1µm to >3mm
*all particle size ranges are sample dependent
**particle size ranges are sample and sensor dependent.
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Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...
Multiple scattering refers to the phenomenon where photons scattered from the sample are re-scattered from neighboring particles prior to reaching the instrument detector.
Number fluctuations are defined as variations in the number of particles within the scattering volume during the course of a dynamic light scattering (DLS) measurement.
Spray drying, which produces a dry powder from a liquid or slurry, is one of the most popularly-used continuous drying processes in which a liquid in the form of an emulsion, wet slurry or suspension is sprayed via a spray nozzle or a rotary atomizer...
In a recent newsletter, the US FDA highlighted the important role Morphologically-Directed Raman Spectroscopy (MRDS) can play in supporting the development of generic drug products. The component-specific particle size and shape distribution data gen...
(Webinar - Recorded)
Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products
(September 20 2016)
Nanoparticle size is an important criterion for our formulations and we routinely measure this with the Zetasizer Nano.
My students have always had great things to say about the Zetasizer Nano. They say it’s very easy to use. The software is very user-friendly and it can accommodate particles of various different sizes, so I have never had reason to evaluate another particle sizing instrument.
Dr. Albena Ivanisevic
Department of Materials Science and Engineering at North Carolina State University
On-line zeta potential measurement is helping us to achieve a more cost-efficient water facility.
The Zetasizer Nano is so easy to use. All my students can familiarise themselves with it very quickly. As a result, we are purchasing a second instrument to ensure we have enough capacity for our expanding research programme in this area.
Department of Chemistry, at The University of Sheffield
Here at IU’s Nanocharacterization facility, the Malvern Zetasizer Nano is the ‘go to’ instrument for characterization of assembled product.
Dr Stella Aniagyei
Indiana University’s (IU) Molecular and Cellular Biochemistry Department
We very much value the customer service and training opportunities from Malvern. In particular, the rapid diagnosis of any issues through direct internet connection with the Malvern customer service team has prevented us from suffering production downtime.
Dr. Cordula Grüttner
micromod Partikeltechnologie GmbH
The big plus of an on-line instrument is real-time monitoring, the value of which was really brought home to us during a recent treatment event. The on-line data we collected during the event gave us new insight into a modified operating scheme that we’re now capitalizing on.
The Malvern systems have proved highly effective, allowing us to further demonstrate the stability and purity of our products and how this may be translated into improving liquid biopharmaceutical formulations.
The Malvern NanoSight NTA system allows us to directly and reliably quantify extracellular vesicle yields from the cell lines under investigation, which is critical to this project.
Ohio State University
With NTA we are able to sensitively monitor the behavior of a nanoparticle over time in a variety of different media.
Département Environnement et Agro-biotechnologies at the CRP - Gabriel Lippmann.
We’ve always been really happy with Malvern and while we’ve tried other companies, the necessary expertise was not there.
the IN-CTSI (Indiana-Clinical Translational Sciences Institute)
The Morphologi G3-ID has proven straightforward and easy to use and we’ve already been successful in expanding our application of it into areas beyond construction materials.
Dr Ameneh Schneider
Association of the Austrian Cement Industry
For us, the Insitec is an essential tool for optimizing the performance of the finishing mills. It provides continuous particle size data, so that the operators can react quickly and confidently when making control decisions. As a result we have increased throughput and enhanced product quality.
Insitec brings value in three areas. It allows us to quantify differences in grindability, supports the development of an effective processing solution and improves the efficiency of our toll manufacturing, which is often a precursor to customer investment.
Insitec is extremely reliable and enables us to provide milling plant for both wet and dry processing that efficiently meets customer goals for premium product quality and low energy consumption.
We have had several researchers become new NRC users because they want to access our Malvern Zetasizer Nano
the Nanotechnology Research Center (NRC) at the Georgia Institute of Technology
The images from the Morphologi G3 provided compelling evidence that the particles, rather than the sizing method, were a root cause of observed variability.
Reading Scientific Services Ltd
After just four months, the Morphologi G3-ID is already heavily used by researchers and students throughout the university. The automated microscopy and image analysis functions are especially popular and have saved countless hours compared with using manual microscopy techniques.
Southern Cross University
The software really is the shining star of the Mastersizer 3000. It makes it feel radically different from other systems on the market and a really great instrument to use. I especially like the live trends which make it so quick and easy to compare data sets.
NSL Analytical Services
The [Zetasizer Nano] instrument is robust, easy to use and data acquisition is straightforward. It is as close to ‘student proof’ as it is possible to be!
Dr Krystelle Mafina
Queen Mary University
Throughout the research and purchasing process, we assessed at least five to six different systems before selecting the Mastersizer 3000.
We can switch between different product grades around three to nine times faster than when we only had offline Blaine measurements for plant control. This has had a major impact on plant throughput. Here we have found the Insitec essential for the production of high quality products.
Mr Thomas Schuster
The technical support that we’ve received has been a deciding factor in our decision to continue to work with Malvern. Malvern systems also provide the cutting-edge performance and reliability that we need.
Domino Printing Sciences plc
The Zetasizer Nano has reliably delivered a substantial portion of data and continues to help drive our research.
NTA is a relatively new addition to the lab but is already bringing value to several areas of research.
Malvern Instruments’ webinars, live chats and technical support are very useful and continue to help our researchers push the boundaries of materials and biomaterials science.
The Insitec systems are a trusted and integral part of our plant. Our view is that real-time data is invaluable when it comes to producing slag cements with comparable performance to conventional products.
As part of the multi-disciplinary lab at QMUL, materials and biomaterials research groups throughout the university, from engineers and chemists through to biologists and physicists, are benefiting from access to analysis using the Zetasizer Nano.
We use software capabilities, which were originally developed by Malvern for pharmaceutical industry users, to apply and demonstrate the analytical rigor required for certification of our powders.
Dr. Robert Deffley
One of the great things about the Nanoparticle Tracking Analysis system is the unique visualization capability which enables real time empirical insight into key particle behavior, such as the propensity and rate of aggregation, as opposed to alternative techniques with often lengthy procedures.
University of Wisconsin-Milwaukee
In a comparative assessment the Morphologi G3 delivered the perfect balance between speed of measurement, image resolution and price.
Malvern came recommended by colleagues in the industry but it was the features of the Mastersizer 3000 itself that sold us on the instrument. We’ve been running for a year now without any reliability issues and with minimal running costs. Most importantly we produce data that can be trusted.
We’ve been running the Zetasizer APS continuously since 2012 and the real beauty is that we simply load the samples in multiwell plates, leave it to run, even overnight, and go back and pick up the results.
Dr Maria Håkansson
Nanoparticle Tracking Analysis has provided us with an instantaneous way of looking at the behavior of the nanoparticles within a biological medium, providing insight unachievable with alternative analysis techniques.
All information supplied within is correct at time of publication.
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