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The biopharmaceutical shift within the drug development industry has focused increasing attention on the behavior of biological molecules in formulation. Aggregation of proteins is key to formulation and stability assessments, with a recent interest in the 100nm - 1µm aggregate size range, identified as an area of concern for immunogenicity and therefore product safety.

While the Zetasizer uses DLS to detect the polydispersity (size spread) of biopharmaceutical formulations, Viscotek SEC products are able to separate particles present in samples by size and enable the quantity of oligomerization to be measured.

Archimedes uses the technique of resonant mass measurement to both reliably count the number of particles in the size range 50nm to 5µm (with a lower limit of detection of 200nm diameter for protein particles specifically), and also to provide measurements such as particle mass and size, and information on sample concentration, viscosity, density and volume. Via its measurement of relative buoyant mass, Archimedes is also able to distinguish between positively buoyant particles such as contaminating silicone oil, and negatively buoyant particles such as protein aggregates.

Malvern NanoSight products, using Nanoparticle Tracking Analysis (NTA) also provide an accurate, reproducible analysis and visualization of particles such as protein aggregates in formulation, in the size range 50nm to 500nm diameter. Enabling the fluorescence mode in NanoSight instruments allows specific analysis of labeled or intrinsically fluorescent particles.

Measurement of these parameters can provide valuable information on the suitability of a product formulation and may also give an indication of the stability and prospective shelf-life of a product.

Depending on your requirements and/or position on the development pipeline, Malvern has an instrument that is able to provide a suitable level of information on issues around protein aggregation, thus ensuring your product achieves the desired stability and efficacy.

Related products

Archimedes Particle Metrology System Image
Measurement
Particle size, Protein aggregation, Particle count
Particle size range
0.05µm to 5µm
Technology
Resonant mass measurement
More information
Zetasizer range The worlds most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Image
Measurement
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
Particle size range
Dispersion type
Wet
Technology
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
More information
NanoSight range Count, size and visualize nanoparticles Image
Measurement
Particle size, Particle count, Protein aggregation
Particle size range
10nm to 2000nm
Technology
Nanoparticle Tracking Analysis
More information
Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Accuracy
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
 

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Zetasizer Nano & NanoSight User Meeting - King of Prussia, PA Classroom based training (English)

Learn More – Discover how to get the best out of your instrument with hands-on one-on-one training sessions. Share More – Share your NanoSight and Zetasizer experience with our user community. See More – Meet technology expe...

Product:
Zetasizer Nano range,NanoSight range
Date:
May 22 2014
Location:
Sheraton Valley Forge, 480 North Gulph Road, King of Prussia, Pennsylvania, PA, USA, 19406
Language:
English
Price:
89

Keywords: English Molecular size Particle count Particle size Zeta potential Dynamic Light Scattering USA Classroom based training Eastern Time Zetasizer Nano range Protein aggregation Biological drug characterization and development NanoSight range Nanoparticle Tracking Analysis 

Zetasizer Nano & NanoSight User Meeting - Westborough, MA Classroom based training (English)

Learn More – Discover how to get the best out of your instrument with hands-on one-on-one training sessions. Share More – Share your NanoSight and Zetasizer experience with our user community. See More – Meet technology experts ...

Product:
Zetasizer Nano range,NanoSight range
Date:
May 7 2014
Location:
Malvern Instruments, Inc., 117 Flanders Rd., Westborough, Massachusetts, MA, USA, 01581
Language:
English
Price:
89

Keywords: English Molecular size Particle count Particle size Zeta potential Dynamic Light Scattering USA Classroom based training Eastern Time Zetasizer Nano range Protein aggregation Biological drug characterization and development NanoSight range Nanoparticle Tracking Analysis 


Number and volume size distributions Application Note (English)

The nature of a particle size distribution analysis by dynamic light scattering is dependent upon the manner in which the particles involved are weighted; whether by number, volume and intensity.  This application note, focusing on protein aggregatio...


Keywords: English Application Note Molecular size Particle size Dynamic Light Scattering Zetasizer Nano range Protein aggregation Proteins Biological drug characterization and development 

Investigating the effects of excipients on the earliest stages of aggregation - Aggregation inhibition by arginine Application Note (English)

Use of static and dynamic light scattering to characterize the stability of lysozyme in the presence and absence of arginine. SLS is used to assess agregation temperature, while DLS is used to measure the various particle sizes present in the two for...


Keywords: English Application Note Molecular size Particle size Zeta potential Dynamic Light Scattering Static Light Scattering Zetasizer Nano range Protein aggregation Proteins Protein mobility Biological drug characterization and development Bio-formulation development 
Previous page Showing results 1 - 5 of 73 Next page

Resource center search

Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

Reset filters
Items shown: 5, 10, 20, ALL
Sort by: Date or Alphabetical
Previous page Showing results 1 - 5 of 73 Next page
Zetasizer Nano & NanoSight User Meeting - King of Prussia, PA Classroom based training (English)

Learn More – Discover how to get the best out of your instrument with hands-on one-on-one training sessions. Share More – Share your NanoSight and Zetasizer experience with our user community. See More – Meet technology expe...

Product:
Zetasizer Nano range,NanoSight range
Date:
May 22 2014
Location:
Sheraton Valley Forge, 480 North Gulph Road, King of Prussia, Pennsylvania, PA, USA, 19406
Language:
English
Price:
89

Keywords: English Molecular size Particle count Particle size Zeta potential Dynamic Light Scattering USA Classroom based training Eastern Time Zetasizer Nano range Protein aggregation Biological drug characterization and development NanoSight range Nanoparticle Tracking Analysis 

Zetasizer Nano & NanoSight User Meeting - Westborough, MA Classroom based training (English)

Learn More – Discover how to get the best out of your instrument with hands-on one-on-one training sessions. Share More – Share your NanoSight and Zetasizer experience with our user community. See More – Meet technology experts ...

Product:
Zetasizer Nano range,NanoSight range
Date:
May 7 2014
Location:
Malvern Instruments, Inc., 117 Flanders Rd., Westborough, Massachusetts, MA, USA, 01581
Language:
English
Price:
89

Keywords: English Molecular size Particle count Particle size Zeta potential Dynamic Light Scattering USA Classroom based training Eastern Time Zetasizer Nano range Protein aggregation Biological drug characterization and development NanoSight range Nanoparticle Tracking Analysis 


Number and volume size distributions Application Note (English)

The nature of a particle size distribution analysis by dynamic light scattering is dependent upon the manner in which the particles involved are weighted; whether by number, volume and intensity.  This application note, focusing on protein aggregatio...


Keywords: English Application Note Molecular size Particle size Dynamic Light Scattering Zetasizer Nano range Protein aggregation Proteins Biological drug characterization and development 

Investigating the effects of excipients on the earliest stages of aggregation - Aggregation inhibition by arginine Application Note (English)

Use of static and dynamic light scattering to characterize the stability of lysozyme in the presence and absence of arginine. SLS is used to assess agregation temperature, while DLS is used to measure the various particle sizes present in the two for...


Keywords: English Application Note Molecular size Particle size Zeta potential Dynamic Light Scattering Static Light Scattering Zetasizer Nano range Protein aggregation Proteins Protein mobility Biological drug characterization and development Bio-formulation development 
Previous page Showing results 1 - 5 of 73 Next page

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