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Zeta potential is a measure of the magnitude of the electrostatic or charge repulsion or attraction between particles, and is one of the fundamental parameters known to affect stability. Its measurement brings detailed insight into the causes of dispersion, aggregation or flocculation, and can be applied to improve the formulation of dispersions, emulsions and suspensions.

Speed of introduction of new formulations is the key to product success. Measurement of zeta potential is one of the ways to shorten stability testing by reducing the number of candidate formulations, hence reducing the time and cost of testing as well as improving shelf life.

In water treatment, monitoring dosage using zeta potential measurements can reduce the cost of chemical additives by optimizing the dosage control.

The measurement of zeta potential has important applications in a wide range of industries including; ceramics, pharmaceuticals, medicine, mineral processing, electronics and water treatment.

Malvern Instruments’ Zetasizer Nano provides a simple, fast and accurate way to measure zeta potential. The unique disposable capillary cell ensures there is no cross contamination between samples, which improves the simplicity, speed and accuracy of the measurement.

Related products

Zetasizer range The worlds most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Image
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
Particle size range
Dispersion type
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
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DLS Microrheology on the Zetasizer Nano ZSP/ZS: Use of a zeta potential pre-measurement step to assess tracer particle-sample interactions Application Note (English)

This technical note describes the practical aspects to consider when making a microrheology measurement by dynamic light scattering, and how zeta potential can be used as an indicator of the interaction between tracer particle and sample.

Keywords: English Application Note Zeta potential Electrophoretic Light Scattering Zetasizer Nano ZS Proteins Zetasizer Nano ZSP Microrheology 

Hit the Target Article (English)

Liposomes are fast becoming a preferred vehicle for delivering therapeutic drug molecules to target sites. This article discusses two techniques for the measurement of their size, concentration and zeta potential.

Keywords: Nanoparticles English Article Particle concentration Particle size Zeta potential Dynamic Light Scattering Electrophoretic Light Scattering Liposomes and micelles Zetasizer Nano range NanoSight range Nanoparticle Tracking Analysis 

Predicting protein formulation stability: Application Note (English)

Use of dynamic and electrophoretic light scattering to assess the effects of protein formulation composition

Keywords: English Application Note Zeta potential Dynamic Light Scattering Static Light Scattering Protein aggregation Proteins Zetasizer Nano ZSP Biological drug characterization and development Bioformulation development 

Investigating the effects of excipients on the earliest stages of aggregation - Aggregation inhibition by arginine Application Note (English)

Use of static and dynamic light scattering to characterize the stability of lysozyme in the presence and absence of arginine. SLS is used to assess agregation temperature, while DLS is used to measure the various particle sizes present in the two for...

Keywords: English Application Note Molecular size Particle size Zeta potential Dynamic Light Scattering Static Light Scattering Protein aggregation Proteins Zetasizer Nano ZSP Protein mobility Biological drug characterization and development Bioformulation development 
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