Archimedes is an innovative, high-performance system which harnesses the technique of resonant mass measurement in order to detect and count particles in the size range 50nm - 5µm and to measure particle mass and size. Archimedes is uniquely positioned to quantitatively measure protein aggregates within and beyond the range of 200nm - 5µm, highlighted as a particular concern for immunogenicity and product safety.

Central to Archimedes is a MEMS (Micro Electro-Mechanical Systems) technology sensor, allowing the highly sensitive, reliable and reproducible measurement of aggregates, one by one. Archimedes is also capable of providing information on sample concentration, viscosity, polydispersity, density and volume, and distinguishing between negatively buoyant proteinaceous particles and positively buoyant contaminating silicone oil droplets.

Parameters measured:

  • Particle number.
  • Particle size.
  • Particle buoyant mass.
  • Particle dry mass.
  • Particle density.
  • Particle surface area.
  • Sample volume.
  • Sample concentration (particles/mL).
  • Sample density.

Key Benefits:

  • Ideally positioned for biopharmaceutical manufacturers and developers.
  • Unique and accurate particle counting capability in the size range 50nm - 5µm.
  • Exquisite sensitivity: measurement of particle mass to 350ag.
  • Highly accurate particle size measurement from 50nm to 5µm.
  • Excellent size resolution, <20nm at 1µm diameter.
  • Low sample consumption: only 100µL.
  • Differentiation between negatively buoyant and positively buoyant particles.
  • Capable of measuring high concentration samples (to 109 particles/mL) and high viscosity samples (to 100cP).
  • Fast, NIST-traceable calibration.
  • Highly reproducible results.
  • Intuitive and flexible ParticleLab software.