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An instrument with a proven history over more than a decade as the world’s most widely used particle sizing instrument, the Mastersizer 2000 is still regarded as one of the most flexible and user friendly particle sizing instruments available.

Overview

The Mastersizer 2000 particle size analyzer has set the standard for simple, straightforward operation. Modular in design, it has a wide range of automated sample dispersion units for the measurement of wet and dry samples. These are controlled through SOPs, providing ease of method development and transfer.

  • Broad particle size range suitable for many different applications.
  • Wide range of sample dispersion options for emulsions, suspensions and dry powders.
  • Fully automated simple SOP operation for ease of use and method transfer.
  • Full validation documentation available including compliance with 21 CFR Part 11.
  • Backed up by extensive applications knowledge across many different industries.

How it works

The Mastersizer 2000 uses the technique of laser diffraction to measure the size of particles. It does this by measuring the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analyzed to calculate the size of the particles that created the scattering pattern.

A typical system is made up of three main elements:

  • Optical bench - A dispersed sample passes though the measurement area of the optical bench, where a laser beam illuminates the particles. A series of detectors then accurately measure the intensity of light scattered by the particles within the sample over a wide range of angles.
  • Sample dispersion units (accessories). Sample dispersion is controlled by a range of wet and dry dispersion units. These ensure the particles are delivered to the measurement area of the optical bench at the correct concentration and in a suitable, stable state of dispersion.
  • Instrument software. The Mastersizer 2000 software controls the system during the measurement process and analyzes the scattering data to calculate a particle size distribution.

Specification

General

Principle:
Laser light scattering.
Analysis:
Mie and Fraunhofer scattering.
Data acquisition rate:
1 kHz

Optics

Red light source:
Max. 4mW He-Ne, 632.8nm
Blue light source:
Max. 0.3mW LED, 470nm
Lens arrangement:
Reverse Fourier (convergent beam)

Particle size

Particle size:
0.02 - 2000 µm *
Accuracy:
Better than 1% (polydisperse standard) **
Reproducibility:
Better than 1% variation (polydisperse standard)

Software

21 CFR part 11:
Enables an operating mode that assists with ER/ES compliance

System

Dimensions (W, D, H):
1293mm x 255mm x 375mm
Weight:
31 kg
Power:
100/240 V, 50/60 Hz

Notes

*:
Sample and sample preparation dependent.
**:
Accuracy defined for the recovery of the mean size of a narrow log-normal distribution. Sample and sample preparation dependant.

Latest software update

5.60
(14/12/2010)
Download update

Accessories

Wet dispersion units

Hydro 2000G Large volume automated wet dispersion accessory. Image The Hydro 2000G is a fully automated large volume wet sample dispersion unit. It is most suitable for QC applications where representative sampling is important, as well as the measurement of polydisperse samples with very broad particle size distributions. More information
Hydro 2000MU Large volume manual wet dispersion accessory Image The Hydro 2000MU is a large volume manual wet sample dispersion unit designed for use with standard laboratory beakers. More information
Hydro 2000S Small volume automated wet dispersion accessory Image The Hydro 2000S is a fully automated small volume wet sample dispersion unit. It is most suitable for applications where the amount of sample or volume of dispersant needs to be minimized. More information
Hydro SM Small volume entry level wet dispersion unit Image The Hydro SM is a cost effective wet sample dispersion unit designed for measuring samples in non-aqueous dispersants where solvent usage needs to be minimized. More information
Hydro 2000µP Small volume wet dispersion accessory Image The Hydro 2000µP is a small volume wet sample dispersion unit designed specifically for measuring small quantities of high value or hazardous materials such as pharmaceutical actives. More information
Autosampler 2000 High throughput particle size measurements. Image For laboratories with a high sample throughput requirement, the Autosampler 2000 delivers fully automated particle size distribution measurements for the Mastersizer 2000. Automatic preparation and dispersion of samples gives true intervention-free operation to free key personnel for other tasks. More information

Dry dispersion units

Scirocco 2000 Dry powder dispersion Image The Scirocco 2000 is an automated dry powder dispersion unit for the Mastersizer 2000 particle size analyzer. More information

Support

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Some customers just need to ask an occasional question or to download a software upgrade, whilst others require a comprehensive support contract with priority call out and fixed cost of ownership. Whatever your situation Malvern will provide the right support for you.

Help Desk

  • Telephone and email support.
  • Operators who take responsibility for your call and ensure your query is answered. 

Training

  • On Site training courses
  • Classroom training
  • E-learning

Resource center

  • Application notes
  • Technical notes
  • On demand presentations
  • Live webinars

Software downloads

  • A simple mechanism for receiving updates and new features

Platinum and Gold Service Contracts

  • Protection from the cost of downtime
  • No time lost in obtaining help when you need it
  • Fixed cost of ownership

Bronze Service Agreements

  • Protect the value of your investment
  • Reduce the risk of downtime
  • Protect the validity of your data
 
 

Resource center search

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Expanding the capabilities of laser diffraction particle size analysis Webinar - Recorded (English)

The launch of the Mastersizer 2000 laser diffraction particle size analyzer in 1998 delivered advances in measurement automation (SOPs) and sample dispersion control which helped to move laser diffraction from being a research technique t...

Product:
Mastersizer 2000,Mastersizer 3000
Date recorded:
September 3 2014
Language:
English

Keywords: English Mastersizer 2000 Mastersizer 3000 Laser diffraction Webinar - Recorded Eastern Time 

Beyond SOPs – Exploring the rigor and requirements of Analytical QbD Whitepaper (English)

Analytical QbD (AQbD) promises to extend the rigor and benefits of QbD into the area of analytical method development. Here, Paul Kippax provides an introduction to the methodology involved and takes as an example the application of AQbD to t...


Keywords: English Whitepaper Mastersizer range Pharmaceutical chemical development Pharmaceutical formulation and development Pharmaceutical manufacturing 

Setting pharmaceutical product specifications for particle size analysis Webinar - Recorded (English)

The end point of any particle size measurement is to provide improved product or process understanding and/or control. It order to achieve this, it is important that the size specifications selected are relevant to those products or processes. In thi...

Product:
Mastersizer range,Morphologi G3
Date recorded:
March 19 2014
Language:
English

Keywords: English Mastersizer range Morphologi G3 Particle shape Particle size Image analysis Laser diffraction Webinar - Recorded Eastern Time Pharmaceutical development 

Laser diffraction Masterclass 6: Troubleshooting Webinar - Recorded (English)

Despite our best efforts to produce a robust particle size distribution measurement methods, things can go wrong! In this presentation, we cover the most common errors which can occurring during laser diffraction measurements.

Product:
Mastersizer range
Date recorded:
November 5 2013
Language:
English

Keywords: English Mastersizer range Particle size Laser diffraction Webinar - Recorded Greenwich Time 

From the application laboratory - Is one measurement enough? Webinar - Recorded (English)

Tempting as it might sound, to take just one measurement of your sample is not enough. Why? Simply because making repeat measurements will help you understand what happens to your sample while is being measured.

Product:
Mastersizer range
Date recorded:
September 24 2013
Language:
English

Keywords: English Mastersizer range Particle size Laser diffraction Webinar - Recorded Greenwich Time 
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