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MicroCal microcalorimeters are powerful, analytical tools used to study biological systems. These include interactions between molecules as well as changes in conformation such as protein unfolding. The technique is very convenient requiring only minimal assay development and NO labelling. The range includes both Differential Scanning and Isothermal Titration calorimetry.
MicroCal microcalorimeters are used in a wide range of applications from basic research to the discovery and development of small molecule drugs, biotherapeutics and vaccines. Our customers include pharmaceutical, biotech, academic and governmental research institutions worldwide.
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Differential Scanning Calorimetry (DSC) studies of lipid thermotropic phase transitions: - Why use DSC for characterization?
- What information does DSC provide?
- The basics of liposome preparation – various techniques (membranes of a single l...
The term ‘epigenetics’ refers to changes in and regulation of gene expression and function, without alteration of DNA sequence. The mechanisms behind these changes involve “epigenetic regulator” proteins that interact with and modify chromatin (DNA w...
The search for novel peptide substrates for proline-specific peptidases has been hampered by a lack of suitable assays. Existing technologies are often too expensive, labor-intensive or require derivatization and separation of the reaction products....
Differential scanning calorimetry (DSC) is widely used to monitor the thermal stability of the molecular conformation of proteins. Here, we present an example of the sensitivity of DSC to changes in stability arising from a common chemical degradatio...
Advantages of the use of Microcal Auto-ITC200 and Microcal VP-Capillary DSC in FBDD campaign. From secondary screening to lead optimization.
(Webinar - Recorded)
DSC is a useful tool to predict the protein stability at lower temperatures, screen buffers and excipients, screen therapeutic candidates and to predict protein aggregation.
DSC is a technology that is valuable in the early phases of protein characterization and formulation development. Critical data about protein stability can be rapidly acquired and used as a guide to support and speed up liquid formulation development projects.
Dr Fredrik Ollila
Novartis Pharma AG.
DSC rapidly determines the factors that contribute to antibody stability, and is a valuable stability indicating technique that can be applied throughout biotherapeutic development.
Stephen J Demarest
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