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MicroCal microcalorimeters are powerful, analytical tools used to study biological systems. These include interactions between molecules as well as changes in conformation such as protein unfolding. The technique is very convenient requiring only minimal assay development and NO labelling. The range includes both Differential Scanning and Isothermal Titration calorimetry.

MicroCal microcalorimeters are used in a wide range of applications from basic research to the discovery and development of small molecule drugs, biotherapeutics and vaccines. Our customers include pharmaceutical, biotech, academic and governmental research institutions worldwide.

MicroCal DSC range Powerful analytical tools for characterizing the stability of proteins and other biomolecules MicroCal DSC Microcalorimeter for microcalorimetry and label free analysis using differential scanning calorimetry
Measurement
Microcalorimetry, Label-free analysis
Temperature range
-10°C to 130°C
Sample throughput
2per 24h day to 50per 24h day
Technology
Differential Scanning Calorimetry
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MicroCal ITC range Determine the binding parameters of biomolecules in a single analysis MicroCal ITC Microcalorimeter for microcalorimetry and label free analysis using isothermal titration calorimetry
Measurement
Microcalorimetry, Label-free analysis
Temperature range
2°C to 80°C
Sample throughput
4per 24h day to 42per 24h day
Technology
Isothermal Titration Calorimetry
More information
 
 

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Using Isothermal Titration Calorimetry to support the development of therapeutic enzymes Webinar - Live (English)

This webinar will describe the use of Isothermal Titration Calorimetry (ITC) to establish the enzymatic properties of a lysosomal enzyme with potential therapeutic value. The technique was used by the team at Swedish Orphan Biovitrum (Sobi) to enable...

Product:
MicroCal ITC range
Date:
October 26 2016
Language:
English


The Power of Heat: Digging Deeper with Differential Scanning Calorimetry to Study Key Protein Characteristics Webinar - Recorded (English)

Differential Scanning Calorimetry (DSC) has a long history of playing a vital role in biopharmaceutical development. From candidate selection to formulation development, stability monitoring and bio-similarity assessment, DSC remains one of the top a...

Product:
MicroCal DSC range
Date recorded:
August 16 2016
Language:
English


A buyer's guide to protein stability measurement platforms Whitepaper (English)

Characterizing biopharmaceutical protein stability is critical during all phases of biopharmaceutical development, including candidate selection, preformulation screening and formulation development, process development, and manufacturing support. Pr...



Characterization of biopharmaceutical stability with Differential Scanning Calorimetry: Candidate selection for developability Whitepaper (English)

Biopharmaceutical proteins are characterized and optimized for stability throughout development. Differential scanning calorimetry (DSC) is a key biophysical assay used to rank order thermal stability. This white paper discusses how DSC is used to se...



Using DSC to characterize thermotropic phase transitions in lipid bilayer membranes Application Note (English)

Liposomes have been widely used as model membranes and in drug delivery, as their basic properties can easily be varied to target desired properties (lipid composition, concentration, water content, media (different buffers, varying ionic strength, p...


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2nd Annual European MicroCal Meeting

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