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MicroCal microcalorimeters are powerful, analytical tools used to study biological systems. These include interactions between molecules as well as changes in conformation such as protein unfolding. The technique is very convenient requiring only minimal assay development and NO labelling. The range includes both Differential Scanning and Isothermal Titration calorimetry.

MicroCal microcalorimeters are used in a wide range of applications from basic research to the discovery and development of small molecule drugs, biotherapeutics and vaccines. Our customers include pharmaceutical, biotech, academic and governmental research institutions worldwide.

MicroCal DSC range Powerful analytical tools for characterizing the stability of proteins and other biomolecules MicroCal DSC Microcalorimeter for microcalorimetry and label free analysis using differential scanning calorimetry
Measurement
Microcalorimetry, Label-free analysis
Temperature range
-10°C to 130°C
Sample throughput
2per 24h day to 50per 24h day
Technology
Differential Scanning Calorimetry
More information
MicroCal ITC range Determine the binding parameters of biomolecules in a single analysis MicroCal ITC Microcalorimeter for microcalorimetry and label free analysis using isothermal titration calorimetry
Measurement
Microcalorimetry, Label-free analysis
Temperature range
2°C to 80°C
Sample throughput
4per 24h day to 42per 24h day
Technology
Isothermal Titration Calorimetry
More information
 
 

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The Power of Heat: Digging Deeper with Differential Scanning Calorimetry to Study Key Protein Characteristics Webinar - Live (English)

Differential Scanning Calorimetry (DSC) has a long history of playing a vital role in biopharmaceutical development. From candidate selection to formulation development, stability monitoring and bio-similarity assessment, DSC remains one of the top a...

Product:
MicroCal DSC range
Date:
August 16 2016
Language:
English


Using DSC to characterize thermotropic phase transitions in lipid bilayer membranes Application Note (English)

Liposomes have been widely used as model membranes and in drug delivery, as their basic properties can easily be varied to target desired properties (lipid composition, concentration, water content, media (different buffers, varying ionic strength, p...



Good practice for studying the stability of liposomes, their use as model systems and in drug delivery Webinar - Recorded (English)

Differential Scanning Calorimetry (DSC) studies of lipid thermotropic phase transitions: - Why use DSC for characterization? - What information does DSC provide? - The basics of liposome preparation – various techniques (membranes of a single l...

Product:
MicroCal DSC range
Date recorded:
June 29 2016
Language:
English


Surfactant micelle characterization Webinar - Recorded (English)

Surfactant micelles are used in a wide variety of applications, from personal care products to pharmaceutical formulations. Dynamic light scattering and isothermal titration calorimetry can be used to characterize micelle size and charge, determine t...

Product:
Zetasizer range,MicroCal ITC range
Date recorded:
June 23 2016
Language:
English


Biophysical characterization of epigenetic protein interactions with chromatin using Isothermal Titration Calorimetry Whitepaper (English)

Epigenetic regulation of genomic DNA for gene expression is important in cellular differentiation and the development of an organism. Epigenetics also contributes to human diseases. On a molecular level, epigenetics involves modification of the histo...


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