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MicroCal microcalorimeters are powerful, analytical tools used to study biological systems. These include interactions between molecules as well as changes in conformation such as protein unfolding. The technique is very convenient requiring only minimal assay development and NO labelling. The range includes both Differential Scanning and Isothermal Titration calorimetry.
MicroCal microcalorimeters are used in a wide range of applications from basic research to the discovery and development of small molecule drugs, biotherapeutics and vaccines. Our customers include pharmaceutical, biotech, academic and governmental research institutions worldwide.
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Differential Scanning Calorimetry (DSC) has a long history of playing a vital role in biopharmaceutical development. From candidate selection to formulation development, stability monitoring and bio-similarity assessment, DSC remains one of the top a...
Liposomes have been widely used as model membranes and in drug delivery, as their basic properties can easily be varied to target desired properties (lipid composition, concentration, water content, media (different buffers, varying ionic strength, p...
Differential Scanning Calorimetry (DSC) studies of lipid thermotropic phase transitions: - Why use DSC for characterization?
- What information does DSC provide?
- The basics of liposome preparation – various techniques (membranes of a single l...
Surfactant micelles are used in a wide variety of applications, from personal care products to pharmaceutical formulations. Dynamic light scattering and isothermal titration calorimetry can be used to characterize micelle size and charge, determine t...
Epigenetic regulation of genomic DNA for gene expression is important in cellular differentiation and the development of an organism. Epigenetics also contributes to human diseases. On a molecular level, epigenetics involves modification of the histo...
(Webinar - Recorded)
DSC is a useful tool to predict the protein stability at lower temperatures, screen buffers and excipients, screen therapeutic candidates and to predict protein aggregation.
DSC is a technology that is valuable in the early phases of protein characterization and formulation development. Critical data about protein stability can be rapidly acquired and used as a guide to support and speed up liquid formulation development projects.
Dr Fredrik Ollila
Novartis Pharma AG.
DSC rapidly determines the factors that contribute to antibody stability, and is a valuable stability indicating technique that can be applied throughout biotherapeutic development.
Stephen J Demarest
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