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MicroCal microcalorimeters are powerful, analytical tools used to study biological systems. These include interactions between molecules as well as changes in conformation such as protein unfolding. The technique is very convenient requiring only minimal assay development and NO labelling. The range includes both Differential Scanning and Isothermal Titration calorimetry.

MicroCal microcalorimeters are used in a wide range of applications from basic research to the discovery and development of small molecule drugs, biotherapeutics and vaccines. Our customers include pharmaceutical, biotech, academic and governmental research institutions worldwide.

MicroCal DSC range Powerful analytical tools for characterizing the stability of proteins and other biomolecules MicroCal DSC Microcalorimeter for microcalorimetry and label free analysis using differential scanning calorimetry
Measurement
Microcalorimetry, Label-free analysis
Temperature range
-10°C to 130°C
Sample throughput
2per 24h day to 50per 24h day
Technology
Differential Scanning Calorimetry
More information
MicroCal ITC range Determine the binding parameters of biomolecules in a single analysis MicroCal ITC Microcalorimeter for microcalorimetry and label free analysis using isothermal titration calorimetry
Measurement
Microcalorimetry, Label-free analysis
Temperature range
2°C to 80°C
Sample throughput
4per 24h day to 42per 24h day
Technology
Isothermal Titration Calorimetry
More information
 
 

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Biophysical characterization of epigenetic interactions and associated drug discovery, using Isothermal Titration Calorimetry Webinar - Recorded (English)

The term ‘epigenetics’ refers to changes in and regulation of gene expression and function, without alteration of DNA sequence. The mechanisms behind these changes involve “epigenetic regulator” proteins that interact with and modify chromatin (DNA w...

Product:
MicroCal ITC range
Date recorded:
April 26 2016
Language:
English


Use of isothermal titration calorimetry to investigate and identify novel peptide substrates for prolyl carboxypeptidase: a technology comparison Webinar - Recorded (English)

The search for novel peptide substrates for proline-specific peptidases has been hampered by a lack of suitable assays. Existing technologies are often too expensive, labor-intensive or require derivatization and separation of the reaction products....

Product:
MicroCal ITC range
Date recorded:
April 13 2016
Language:
English


Using DSC to investigate the impact of oxidation on protein structure Webinar - Recorded (English)

Differential scanning calorimetry (DSC) is widely used to monitor the thermal stability of the molecular conformation of proteins. Here, we present an example of the sensitivity of DSC to changes in stability arising from a common chemical degradatio...

Product:
MicroCal DSC range
Date recorded:
January 19 2016
Language:
English


Advantages of Microcal Auto-ITC200 Poster (English)

Advantages of the use of Microcal Auto-ITC200 and Microcal VP-Capillary DSC in FBDD campaign. From secondary screening to lead optimization.



Studying enzyme kinetics through Isothermal Titration Calorimetry Webinar - Recorded (English)

Isothermal Titration Calorimetry (ITC) is a technique that measures the heat released or absorbed during a chemical reaction as an intrinsic probe to characterize any chemical process. In the present webinar, the experimental ITC-based methods to qua...

Product:
MicroCal ITC range
Date recorded:
November 12 2015
Language:
English

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