Skip to left navigation
Skip to page content
MicroCal microcalorimeters are powerful, analytical tools used to study biological systems. These include interactions between molecules as well as changes in conformation such as protein unfolding. The technique is very convenient requiring only minimal assay development and NO labelling. The range includes both Differential Scanning and Isothermal Titration calorimetry.
MicroCal microcalorimeters are used in a wide range of applications from basic research to the discovery and development of small molecule drugs, biotherapeutics and vaccines. Our customers include pharmaceutical, biotech, academic and governmental research institutions worldwide.
Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.
This webinar will describe the use of Isothermal Titration Calorimetry (ITC) to establish the enzymatic properties of a lysosomal enzyme with potential therapeutic value. The technique was used by the team at Swedish Orphan Biovitrum (Sobi) to enable...
Differential Scanning Calorimetry (DSC) has a long history of playing a vital role in biopharmaceutical development. From candidate selection to formulation development, stability monitoring and bio-similarity assessment, DSC remains one of the top a...
Characterizing biopharmaceutical protein stability is critical during all phases of biopharmaceutical development, including candidate selection, preformulation screening and formulation development, process development, and manufacturing support. Pr...
DSC is an established analytical tool used during preformulation and formulation development of biopharmaceuticals. Rank ordering of thermal transition midpoint (TM) by DSC is commonly used to screen formulation buffers, pH and excipients. Typicalll...
Biopharmaceutical proteins are characterized and optimized for stability throughout development. Differential scanning calorimetry (DSC) is a key biophysical assay used to rank order thermal stability. This white paper discusses how DSC is used to se...
(Webinar - Recorded)
DSC is a useful tool to predict the protein stability at lower temperatures, screen buffers and excipients, screen therapeutic candidates and to predict protein aggregation.
DSC is a technology that is valuable in the early phases of protein characterization and formulation development. Critical data about protein stability can be rapidly acquired and used as a guide to support and speed up liquid formulation development projects.
Dr Fredrik Ollila
Novartis Pharma AG.
DSC rapidly determines the factors that contribute to antibody stability, and is a valuable stability indicating technique that can be applied throughout biotherapeutic development.
Stephen J Demarest
All information supplied within is correct at time of publication.
Malvern Instruments pursues a policy of continual improvement due to technical development. We therefore reserve the right to deviate from information, descriptions, and specifications in this publication without notice. Malvern Instruments shall not be liable for errors contained herein or for incidental or consequential damages in connection with the furnishing, performance or use of this material.
Malvern and the 'hills' logo, Bohlin, Gemini, Insitec, ISys, Kinexus, Mastersizer, Morphologi, Rosand, SyNIRgi, Viscotek and Zetasizer, are International Trade Marks owned by Malvern Instruments Ltd.