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MicroCal microcalorimeters are powerful, analytical tools used to study biological systems. These include interactions between molecules as well as changes in conformation such as protein unfolding. The technique is very convenient requiring only minimal assay development and NO labelling. The range includes both Differential Scanning and Isothermal Titration calorimetry.
MicroCal microcalorimeters are used in a wide range of applications from basic research to the discovery and development of small molecule drugs, biotherapeutics and vaccines. Our customers include pharmaceutical, biotech, academic and governmental research institutions worldwide.
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Differential scanning calorimetry (DSC) is a well-established technique for biomolecular stability studies. The technique is based on forced thermal denaturation of the biomolecules. It is extensively used for characterization of protein stability, c...
This webinar focuses on the use and application of differential scanning calorimetry (DSC) for structure and stability investigations of biopharmaceuticals, with an emphasis on monoclonal antibodies, in both early development and late stage products....
Learn why isothermal titration calorimetry is a method of choice for accurate and precise determination of critical micellar concentration of surfactants for industrial and biochemical applications and find out how to analyse demicellization data fro...
Operating instructions for the MicroCal Auto-ITC200 instrument
User manual for the MicroCal PEAQ-ITC system
(Webinar - Recorded)
DSC rapidly determines the factors that contribute to antibody stability, and is a valuable stability indicating technique that can be applied throughout biotherapeutic development.
Stephen J Demarest
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