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The Morphologi G3-ID offers a unique capability, combining the automated static imaging features of the Morphologi G3 with chemical identification of individual particles using Morphologically-Directed Raman Spectroscopy to enable the measurement of component-specific particle size and particle shape distributions.


This fully automated instrument is designed to allow both particle characterization scientists with limited spectroscopy experience and more experienced spectroscopists to get an in-depth understanding of their particulate samples. 

Key features include:

  • Measures particle size, shape and chemical identity in one platform.
  • Automates Morphologi G3 with Kaiser Optical Systems RamanRxn1™ spectrometer.
  • Integrated dry powder dispersion with accurate dispersion energy control automates sample preparation for consistent measurements of both fragile and robust materials.
  • Versatile sample presentation accessories for measuring suspended and filtered samples.
  • Simple SOP operation from sample dispersion through to size, shape and chemical analysis.
  • Automatic selection, targeting and chemical classification of thousands of individual particles.
  • Export function for third party forensic library investigations.
  • Direct Raman spectrum export to (Bio-Rad) KnowItAll® ID Expert software for spectral library search.
  • Single point manual targeting mode for manual selection of particles for chemical analysis.
  • Powerful and intuitive software interface making both visual and statistical interpretation of your data easier than ever.

How it works

The Morphologi G3-ID is ideally suited to solving complex particle characterization problems where component-specific particle size and shape distributions are required. This includes measurement of components within powder blends and suspensions, along with the identification of contaminant or suspicious particles within product formulations.

The measurement workflow can be divided into three distinct steps, each of which can be automated:

  • Sample preparation
    This step is critical to getting good results; spatial separation of individual particles and agglomerates is the goal. The Morphologi G3-ID has an integrated dry powder disperser which makes preparing dry powder samples easy and reproducible. The applied dispersion energy can be precisely controlled, enabling the measurement process to be optimized for a range of material types. Dispersion is achieved without explosively shocking the particles, avoiding the damage of fragile particles while ensuring strongly agglomerated materials are dispersed. Effective dispersion of fibers can also be achieved. Accessories for presenting suspended or filtered samples that fit directly into the Morphologi G3-ID’s automated stage are also available.
  • Particle size and shape measurement
    The instrument automatically measures the size and shape of particles in a dispersed sample in exactly the same manner as the Morphologi G3. This ensures there is no compromise on the reliability of the particle size and shape data, which is not the case with many chemical mapping and imaging techniques.
  • Chemical identification
    The instrument automatically finds particles of interest for chemical identification based on pre-defined classification rules. A Raman spectrum is acquired from the center of mass of each particle. Chemical identification is then achieved based upon established spectroscopic algorithms incorporated within the Morphologi G3-ID software. This allows enumeration of defined classes of particles as well as the reporting of component-specific particle size and shape distributions. Spectra of unknown particles can be directly exported to Bio-Rad’s KnowItAll® ID Expert software for comparison against its Raman library containing over 13,000 spectra.



Static automated imaging combined with Raman spectroscopy
Morphological analysis:
Static automated imaging
Particle size:
1 µm – 1000 µm*
Particle properties measured:
Size, shape, transparency, count, location, chemical identification
Particle size parameters:
Circle equivalent (CE) diameter, length, width, perimeter, area, maximum distance, sphere equivalent (SE) volume, fiber total length, and fiber width
Particle shape parameters:
Aspect ratio, circularity, convexity, elongation, high sensitivity (HS) circularity, solidity fiber elongation, fiber straightness
Particle transparency parameters:
Intensity mean, intensity standard deviation

Sample dispersion

Dispersion mechanism:
Sample entrainment, leading to particle shear and particle impaction
Dispersion pressure range:
0.5 bar – 5 bar
Dispersion pressure precision:
0.1 bar increments
Injection time range:
5 msec - 100 msec
Sample Settling time:
1 s - 600 s
Sample presentation options:
4-slide holder for standard microscope slides 
2-slide holder for large microscope slides 
25 mm and 47 mm dia. holders for membrane filters
Thin-path wet cell for low volume particle suspensions


Light source:
White light, brightfield diascopic and episcopic
5M pixel 2592 x 1944 color CCD array
Pixel width:
2.78 µm x 2.78 µm
Optical system:
Nikon CFI 60 brightfield/darkfield system
2.5x, 5x, 10x, 20x, 50x
Particle size:

[For fully automated Chemical ID measurements (see Morphologi G3 product page for standard particle size specification)]
2.5x: 100 µm – 1000 µm (nominal)
5x: 25 µm – 420 µm (nominal)
10x: 20 µm – 210 µm (nominal)
20x: 20 µm – 100 µm (nominal)
50x: 1 µm – 40 µm (nominal)


Chemical analysis:
Raman spectroscopy
Raman spectrometer:
Kaiser Optical Systems Inc. RamanRxn1
Spectral performance:
150 cm-1 to 1850 cm-1, 6 cm-1 resolution
785 nm
<500 mW (spectrometer)
> 10 mW nominal (at sample)
Laser spot size:
3 µm at 50x magnification
Laser safety:
Class 3B
Chemical identification method:
Spectral correlation
The Morphologi G3-ID and Morphologi G3-ID are protected by copyright and design rights, together with patents based on EP2106536A1 and US8111395B2

Weight and dimensions:

Dimensions (W, D, H):
Main instrument: 440 mm x 760 mm x 750 mm
Dimensions (W, D, H):
Spectrometer: 584 mm x 448 mm x 203 mm
Main instrument: 80 kg approx
Spectrometer: 27.7 kg

Operating environment:

100 V - 240 V ac 50/60 Hz 6.0 A
Operating temperature (°C):
+15°C to +30°C
Storage temperature:
-15°C to +30°C
0%–95%, non-condensing


Sample and substrate dependent. Instrument can also be used as a Morphologi G3. See Morphologi G3 page for details on performance capabilities


The characterization of particles in suspension is a subject of interest for a variety of applications. For example, in pharmaceutical products the presence of inherent, extrinsic or intrinsic particles may affect the efficacy or possibly the safety of the drug. In the automotive industry, the presence of particulate contamination in hydraulic fluid power systems interferes with lubrication and causes wear to components. Many standards specify microscopy analysis for the enumeration of foreign particles in suspensions, and define particulate count limits for a given volume of sample.

Malvern’s range of sample presentation accessories for the Morphologi G3-ID expands the capabilities of this system beyond the characterization of dry sample dispersions. Each accessory fits directly into the Morphologi G3-ID’s automated stage and is easily selectable in the software. KnowItAll® ID Expert software works alongside Morphologi G3-ID software to provide effective support for chemical identification.

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Identification software

KnowItAll® ID Expert software platform from Bio-Rad 600x400-Morpho-KnowitAll-SW-01 Bio-Rad’s KnowItAll® ID Expert software platform works seamlessly with Malvern’s Morphologi software to provide rapid identification of your Raman spectra. More information

Accessories to use when analyzing particles in suspension

Thin-path wet cell 600x400-Morpho-Thin-path-cell-01 The thin-path wet cell is designed for both morphological and chemical characterization of up to 100 μL of sample. It is ideal for applications such as the identification of subvisible particles in therapeutics (described by guidance in USP <787> and USP <788>), especially when a traditional membrane filtering approach may risk changing particles of interest, such as protein aggregates.
2-slide and 4-slide holders 600x400-Morpho-4slide-Hold-01 ‘Sandwiching’ a few μL of a suspension of smaller particles between a microscope slide and a cover slip is a traditional method of sample preparation for microscopy. Samples are presented in this form to the Morphologi G3-ID using either the 2-slide or 4-slide holder. Slides suitable for chemical identification applications are available. Visit store to buy now

Accessories to use when analyzing particles captured on a membrane filter

25 mm and 47 mm diameter filter holders 600x400-Morpho-25mmFilter-Hold-01 Methods which are used to detect and characterize particles in suspension often rely on filtering the sample in order to capture particles on a membrane filter. Dedicated filter holders (25 mm or 47 mm diameter) and also the 2-slide holder (see above) allow samples on filter membranes to be presented directly to the Morphologi G3-ID for analysis. Visit store to buy now


Protect your investment and ensure optimized performance at all times with Malvern’s service plans.

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern will provide the support for your business.

Help Desk


Software downloads

Malvern’s service options- choose the right plan for you:


Malvern Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.


Malvern Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.


Malvern Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum PlanGold PlanBronze Visit
Annual PM/PV Test
Telephone / Email Support
Priority Response
Emergency Breakdown visits*
Parts Included
Technical & Software Support
IQ/OQ (Pharma)***

*including labour & travel costs***available at an additional cost


Resource center search

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Controlling powder bulk density by optimizing particle size and shape distribution Webinar - Recorded (English)

Bulk density is a property of particulate matter including powders, granules or larger aggregates and is a measure of the weight per unit volume of a collection of particles. The control of bulk density is important for a variety of reasons. For e...

Mastersizer range,Morphologi range
Date recorded:
October 6 2016

Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products Webinar - Recorded (English)

Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...

Archimedes,Zetasizer range,Viscotek SEC-MALS,Morphologi G3-ID,NanoSight range
Date recorded:
September 20 2016

Rapid Generic Pharmaceutical Product Development Webinar - Recorded (English)

In a recent newsletter, the US FDA highlighted the important role Morphologically-Directed Raman Spectroscopy (MRDS) can play in supporting the development of generic drug products. The component-specific particle size and shape distribution data gen...

Morphologi G3-ID
Date recorded:
July 12 2016

Monitoring the impact of processing on the size and shape of API particles Webinar - Recorded (English)

As the pharmaceutical industry continues to move towards a quality by design (QbD) paradigm, the design and control of active pharmaceutical ingredient (API) particle characteristics, in particular the control of API particle size and habit with resp...

Morphologi G3-ID,Morphologi G3
Date recorded:
June 21 2016

Optimizing powder packing behavior by controlling particle size and shape Whitepaper (English)

The mechanical properties of materials such as concrete, metal powders, and ceramics are governed by how well we can pack the different sizes and shapes of particles together. There are a whole bunch of properties that influence particle packing beha...

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