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The Morphologi G3-ID provides a unique capability, combining automated static imaging features of the Morphologi G3 with chemical identification of individual particles using Raman spectroscopy to enable the measurement of component specific particle size and particle shape distributions.


This fully automated instrument is designed to allow both particle characterization scientists with limited spectroscopy experience and more experienced spectroscopists to get an in-depth understanding of their particulate samples. Key features:

  • Measures particle size, shape and chemical identity in one platform.
  • Automates Morphologi G3 with Kaiser Optical Systems RamanRxn1 spectrometer.
  • Integrated dry powder dispersion with accurate dispersion energy control automates sample preparation for consistent measurements of both fragile and robust materials.
  • Simple SOP operation from sample dispersion through to size, shape and chemical analysis.
  • Automatic selection, targeting and chemical classification of 1000’s of individual particles.
  • Export function for third party forensic library investigations.
  • Single point manual targeting mode for manual selection of particles for chemical analysis.
  • Powerful and intuitive software interface making both visual and statistical interpretation of your data easier than ever.

How it works

The Morphologi G3-ID is ideally suited to solving complex particle characterization problems where component-specific particle size and shape distributions are required. This includes measurement of components within powder blends and suspensions, along with the identification of contaminant or suspicious particles within product formulations.

The measurement workflow can be divided into three distinct steps, each of which can be automated:

  • Sample preparation
    This step is critical to getting good results; spatial separation of individual particles and agglomerates is the goal. The Morphologi G3SE has an integrated dry powder disperser which makes preparing dry powder samples easy and reproducible. The applied dispersion energy can be precisely controlled, enabling the measurement process to be optimised for a range of material types. Dispersion is achieved without explosively shocking the particles, avoiding the damage of fragile particles while ensuring strongly agglomerated materials are dispersed. Effective dispersion of fibres can also be achieved.
  • Particle size and shape measurement
    The instrument automatically measures the size and shape of particles in a dispersed sample in exactly the same manner as the Morphologi G3. This ensures there is no compromise on the reliability of the particle size and shape data, which is not the case with many chemical mapping and imaging techniques.
  • Chemical identification
    The instrument automatically finds particles of interest for chemical identification based on pre-defined classification rules. A Raman spectrum is acquired from the center of mass of each particle. Chemical identification is then achieved based upon established spectroscopic algorithms incorporated within the Morphologi G3-ID software. This allows enumeration of defined classes of particles as well as the reporting of component specific particle size and shape distributions.



Static automated imaging combined with Raman spectroscopy.
Morphological analysis:
Static automated imaging.
Particle size:
1 µm – 1000 µm*.
Particle properties measured:
Size, shape, transparency, count, location, chemical identification.
Particle size parameters:
Circle equivalent (CE) diameter, length, width, perimeter, area, maximum distance, sphere equivalent (SE) volume, fiber total length, and fiber width.
Particle shape parameters:
Aspect ratio, circularity, convexity, elongation, high sensitivity (HS) circularity, solidity fiber elongation, fiber straightness
Particle transparency parameters:
Intensity mean, intensity standard deviation.

Sample dispersion (Morphologi G3SE-ID only)

Integrated Sample Dispersion Unit option (Morphologi G3SE only):
Dispersion mechanism:
Sample entrainment, leading to particle shear and particle impaction.
Dispersion pressure range:
0.5 – 5 bar.
Dispersion pressure precision:
0.1 bar increments.
Injection time range:
5 - 100 msec
Sample Settling time:
1-600 sec.


Light source:
White light, brightfield diascopic and episcopic.
5M pixel 2592 x 1944 color CCD array.
Pixel width:
2.78 µm x 2.78 µm.
Optical system:
Nikon CFI 60 brightfield/darkfield system.
2.5x, 5x, 10x, 20x, 50x
Particle size:
100-1000µm, 25-420µm, 20-210µm, 20-100µm, 1-40µm,


Chemical analysis:
Raman spectroscopy.
Raman spectrometer:
Kaiser optical systems Inc. RamanRxn1.
Spectral performance:
150 cm-1 to 1850 cm-1, 6 cm-1 resolution
<500 mW (Spectrometer).
> 10 mW nominal (at sample).
Laser spot size:
3 µm at 50x magnification.
Laser safety:
Class 3B.
Chemical identification method:
Spectral correlation.
The Morphologi G3-ID and Morphologi G3SE-ID are protected by copyright and design rights, together with patents based on EP2106536A1 and US8111395B2.

Weight and dimensions:

Dimensions (W, D, H):
Main instrument: 440mm x 760mm x 750mm
Dimensions (W, D, H):
Spectrometer: 584mm x 448mm x 203mm
Main instrument: 80 kg approx.
Spectrometer: 27.7 kg

Operating environment:

100-240 V ac 50/60 Hz 6.0 A
Operating temperature (°C):
+15 to +30°C
Storage temperature:
-15 to +30°C
0–95%, non-condensing


Sample and substrate dependent. Instrument can also be used as a Morphologi G3. See Morphologi G3 page for details on performance capabilities.


When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Some customers just need to ask an occasional question or to download a software upgrade, whilst others require a comprehensive support contract with priority call out and fixed cost of ownership. Whatever your situation Malvern will provide the right support for you.

Help Desk

  • Telephone and email support.
  • Operators who take responsibility for your call and ensure your query is answered. 


  • On Site training courses
  • Classroom training
  • E-learning

Resource center

  • Application notes
  • Technical notes
  • On demand presentations
  • Live webinars

Software downloads

  • A simple mechanism for receiving updates and new features

Platinum and Gold Service Contracts

  • Protection from the cost of downtime
  • No time lost in obtaining help when you need it
  • Fixed cost of ownership

Bronze Service Agreements

  • Protect the value of your investment
  • Reduce the risk of downtime
  • Protect the validity of your data

Resource center search

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Characterization of protein aggregates in suspension and on a filter membrane by Morphologically-Directed Raman Spectroscopy Application Note (English)

The combination of static microscopy and Raman spectroscopy in the Morphologi G3-ID enables automated chemical identification of protein aggregates and other contaminants in a biotherapeutic sample, either in suspension via a thin-path wet cell or on...

Discriminating between polymorphs of acetaminophen using Morphologically-Directed Raman Spectroscopy (MDRS) Application Note (English)

Polymorphic conversions are an ongoing problem in the pharmaceutical industry.  Here we describe the use of Morphologically-Directed Raman Spectroscopy to distinguish and quantify particles of different polymorphic types of acetaminophen (paracetamol...

Forensic Analyses by Morphologically Directed Raman Spectroscopy Webinar - Recorded (English)

Morphologically Directed Raman Spectroscopy (MDRS) can be applied to a variety of forensic evidence types, such as illicit drugs, counterfeit pharmaceuticals, hoax powders, soils and gunshot residues. It is a novel and reliable tool that would enable...

Morphologi G3-ID
Date recorded:
May 28 2015

Keywords: English Chemical identification Webinar - Recorded Eastern Time Morphologi G3-ID 

Application of particle size analysis in Oral Solid Dose product formulation Webinar - Recorded (English)

The development of oral solid dose (OSD) products requires a knowledge of how the physical properties of the excipients and active pharmaceutical ingredients (APIs) present within a formulation affect product performance. This requires access to rele...

Morphologi range,Mastersizer range
Date recorded:
May 20 2015

Keywords: English Mastersizer range Particle size Laser diffraction Raman spectroscopy Webinar - Recorded Eastern Time Morphologi range 

Detecting agglomerates within pharmaceutical formulations Article (English)

Particle agglomeration can compromise the clinical efficacy of pharmaceutical products and must therefore be closely controlled. Automated particle image analysis provides one technology which can aid agglomerate detection. This article provides prac...

Keywords: QA/QC and routine testing Development English Article Particle shape Particle size Image analysis Pharmaceutical formulation and development Pharmaceutical manufacturing Morphologi range 
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