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The Malvern NanoSight LM10 instrument provides an easy-to-use, reproducible platform for nanoparticle characterization.

The LM10 allows rapid and accurate analysis of the size distribution and concentration of all types of nanoparticles from 10nm to 2000nm in diameter, depending on the instrument configuration and sample type.

Overview

The Malvern NanoSight LM10 is a highly flexible and robust instrument that can be upgraded at any time to fit the changing needs of both routine testing and research laboratories.

  • Simultaneous measurement of multiple characteristics saving time and sample volume.
  • Visual validation of results gives extra confidence.
  • User friendly software with easy set up of SOPs for routine use.
  • Minimal sample preparation.
  • Choice of standard or high sensitivity camera.
  • Choice of sample chamber with or without temperature control.
  • Choice of interchangeable laser blocks and wavelengths.

How it works

The Malvern NanoSight LM10 uses the technology of Nanoparticle Tracking Analysis (NTA). This unique technology utilizes the properties of both light scattering and Brownian motion in order to obtain the size distribution and concentration measurement of particles in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualized via a 20x magnification microscope onto which is mounted a camera. The camera operates at 30 frames per second (fps), capturing a video file of the particles moving under Brownian motion. The software tracks many particles individually and using the Stokes-Einstein equation calculates their hydrodynamic diameters.

Specification

General

Wavelength:
405nm (violet), 488nm (blue), 532nm (green) or 642nm (red).
Temperature control range:
Optional (5°C below ambient to 55°C).
Stage:
Manual stage.
Focus:
Manual focus.
Camera:
CCD or sCMOS.
Fluorescence:
Manual push/pull filter holder with 2 filters.
Dimensions (W, D, H):
420mm x 200mm x 260mm.
Particle size:
10nm to 2000nm.
Concentration range:
106 to 109 particles per mL.
Power:
110V - 220V

Latest software update

3.10-I2
(15/06/2015)
Download update

Accessories

NanoSight LM10

NanoSight syringe pump Image The Malvern NanoSight syringe pump is available for all Malvern NanoSight systems, enabling users to perform sample analysis at a constant flow rate. More information

Support

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Some customers just need to ask an occasional question or to download a software upgrade, whilst others require a comprehensive support contract with priority call out and fixed cost of ownership. Whatever your situation Malvern will provide the right support for you.

Help Desk

  • Telephone and email support.
  • Operators who take responsibility for your call and ensure your query is answered. 

Training

  • On Site training courses
  • Classroom training
  • E-learning

Resource center

  • Application notes
  • Technical notes
  • On demand presentations
  • Live webinars

Software downloads

  • A simple mechanism for receiving updates and new features

Platinum and Gold Service Contracts

  • Protection from the cost of downtime
  • No time lost in obtaining help when you need it
  • Fixed cost of ownership

Bronze Service Agreements

  • Protect the value of your investment
  • Reduce the risk of downtime
  • Protect the validity of your data
 
 

Resource center search

Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

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NTA: Exosomes and Microvesicles - General Whitepaper (English)

The need to characterize different properties of nanomaterials continues to grow rapidly. Since the commercialization of the technique in 2004, Nanoparticle tracking Analysis (NTA) has become increasingly prevalent in a wide variety of different rese...


Keywords: English Whitepaper Particle concentration Particle size NanoSight NS500 NanoSight NS300 NanoSight LM10 Exosomes and microvesicles Nanoparticle Tracking Analysis Fluorescence detection 

NTA Concentration Upgrade Webinar - Recorded (English)

An overview of the NTA Concentration Measurement upgrade which gives improved concentration data by further reducing the influence of user settings and allowing improved inter- and intra-laboratory comparison of concentration data.

Product:
NanoSight range,NanoSight NS300,NanoSight NS500
Date recorded:
June 18 2015
Language:
English

Keywords: Nanoparticles English DNA/RNA and oligonucleotides Liposomes and micelles Viruses and vaccines Webinar - Recorded Greenwich Time NanoSight range NanoSight NS500 NanoSight NS300 Exosomes and microvesicles Nanoparticle Tracking Analysis 

NTA Fluorescence mode Webinar - Recorded (English)

This short presentation will give an overview of fluorescence and what you need to think about before you start making measurements of fluorescent samples with NanoSight instruments.

Product:
NanoSight range
Date recorded:
June 18 2015
Language:
English

Keywords: Nanoparticles English DNA/RNA and oligonucleotides Liposomes and micelles Viruses and vaccines Webinar - Recorded Greenwich Time NanoSight range Exosomes and microvesicles Nanoparticle Tracking Analysis Fluorescence detection 

Fluorescence Masterclass - The basics Webinar - Recorded (English)

Fluorescence is increasingly considered as a tool within nanoparticle characterisation. The ability to positively identify particular subsets of nanoparticles within a sample is especially important for applications in life science, drug delivery, vi...

Product:
NanoSight range
Date recorded:
June 16 2015
Language:
English

Keywords: English Webinar - Recorded Eastern Time NanoSight range Nanoparticle Tracking Analysis Fluorescence detection 

NanoSight NTA Concentration Measurement Upgrade Technical Note (English)

NanoSight instruments with upgraded concentration measurement have increased concentration measurement accuracy and repeatability. This provides improved measurement robustness and removes the influence of user settings. Data is shown here that illus...


Keywords: Nanoparticles English Technical Note Particle concentration Particle size NanoSight range Nanoparticle Tracking Analysis 
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Glossary

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The Malvern NanoSight NTA system allows us to directly and reliably quantify extracellular vesicle yields from the cell lines under investigation, which is critical to this project.


Dr Paulaitis, Ohio State University, United States

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