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The Malvern NanoSight LM10 instrument provides an easy-to-use, reproducible platform for nanoparticle characterization.

The LM10 allows rapid and accurate analysis of the size distribution and concentration of all types of nanoparticles from 10nm to 2000nm in diameter, depending on the instrument configuration and sample type.

Overview

The Malvern NanoSight LM10 is a highly flexible and robust instrument that can be upgraded at any time to fit the changing needs of both routine testing and research laboratories.

  • Simultaneous measurement of multiple characteristics saving time and sample volume.
  • Visual validation of results gives extra confidence.
  • User friendly software with easy set up of SOPs for routine use.
  • Minimal sample preparation.
  • Choice of standard or high sensitivity camera.
  • Choice of sample chamber with or without temperature control.
  • Choice of interchangeable laser blocks and wavelengths.

How it works

The Malvern NanoSight LM10 uses the technology of Nanoparticle Tracking Analysis (NTA). This unique technology utilizes the properties of both light scattering and Brownian motion in order to obtain the size distribution and concentration measurement of particles in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualized via a 20x magnification microscope onto which is mounted a camera. The camera operates at 30 frames per second (fps), capturing a video file of the particles moving under Brownian motion. The software tracks many particles individually and using the Stokes-Einstein equation calculates their hydrodynamic diameters.

Specification

General

Wavelength:
405nm (violet), 488nm (blue), 532nm (green) or 642nm (red).
Temperature control range:
Optional (5°C below ambient to 55°C).
Stage:
Manual stage.
Focus:
Manual focus.
Camera:
CCD or sCMOS.
Fluorescence:
Manual push/pull filter holder with 2 filters.
Dimensions (W, D, H):
420mm x 200mm x 260mm.
Particle size:
10nm to 2000nm.
Concentration range:
106 to 109 particles per mL.
Power:
110V - 220V

Latest software update

3.10-I2
(15/06/2015)
Download update

Accessories

NanoSight LM10

NanoSight syringe pump Image The Malvern NanoSight syringe pump is available for all Malvern NanoSight systems, enabling users to perform sample analysis at a constant flow rate. More information

Support

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Some customers just need to ask an occasional question or to download a software upgrade, whilst others require a comprehensive support contract with priority call out and fixed cost of ownership. Whatever your situation Malvern will provide the right support for you.

Help Desk

  • Telephone and email support.
  • Operators who take responsibility for your call and ensure your query is answered. 

Training

  • On Site training courses
  • Classroom training
  • E-learning

Resource center

  • Application notes
  • Technical notes
  • On demand presentations
  • Live webinars

Software downloads

  • A simple mechanism for receiving updates and new features

Platinum and Gold Service Contracts

  • Protection from the cost of downtime
  • No time lost in obtaining help when you need it
  • Fixed cost of ownership

Bronze Service Agreements

  • Protect the value of your investment
  • Reduce the risk of downtime
  • Protect the validity of your data
 
 

Resource center search

Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

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NTA: Exosomes and Microvesicles - General Whitepaper (English)

The need to characterize different properties of nanomaterials continues to grow rapidly. Since the commercialization of the technique in 2004, Nanoparticle tracking Analysis (NTA) has become increasingly prevalent in a wide variety of different rese...



Fluorescence Masterclass 2 - Be data driven Webinar - Live (English)

Fluorescence is becoming an increasingly considered as a tool within nanoparticle characterisation. The ability to positively identify particular subsets of nanoparticles within a sample is especially important for applications in life science, drug ...

Product:
NanoSight range
Date:
August 11 2015
Language:
English


Measuring the Protein Corona and Self Assembled Drug-Albumin Protein Nanoparticles Webinar - Live (English)

During this webinar, we will introduce the Nanoparticle Tracking Analysis (NTA) technique and discuss how it can provide a range of useful characterization information for protein corona and self-assembled albumin-drug nanoparticles. Reviews of the ...

Product:
NanoSight range
Date:
August 20 2015
Language:
English


The importance of the measurement of diffusion in 2-phase systems Webinar - Live (English)

The movement of particles in a colloidal suspension is the property we use in order to characterize the size distribution (via the Stokes-Einstein equation). We'll look at diffusion including the random Brownian motion that we require for valid appli...

Product:
NanoSight range
Date:
August 13 2015
Language:
English


Optimizing Exosome and Extracellular Vesicle Measurements by NTA Webinar - Live (English)

In this webinar we discuss techniques for producing high quality size distribution and concentration measurements for extracellular vesicle preparations with NanoSight. For characterizing the size and concentration of EVs the focus will be on underst...

Product:
NanoSight range
Date:
August 5 2015
Language:
English

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Glossary

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Upcoming webinar

Optimizing Exosome and Extracellular Vesicle Measurements by NTA
(August 5 2015)

More information

The Malvern NanoSight NTA system allows us to directly and reliably quantify extracellular vesicle yields from the cell lines under investigation, which is critical to this project.


Dr Paulaitis, Ohio State University, United States

Read full details

 
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