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The Malvern NanoSight LM10 instrument provides an easy-to-use, reproducible platform for nanoparticle characterization.

The LM10 allows rapid and accurate analysis of the size distribution and concentration of all types of nanoparticles from 10nm to 2000nm in diameter, depending on the instrument configuration and sample type.

Overview

The Malvern NanoSight LM10 is a highly flexible and robust instrument that can be upgraded at any time to fit the changing needs of both routine testing and research laboratories.

  • Simultaneous measurement of multiple characteristics saving time and sample volume.
  • Visual validation of results gives extra confidence.
  • User friendly software with easy set up of SOPs for routine use.
  • Minimal sample preparation.
  • Choice of standard or high sensitivity camera.
  • Choice of sample chamber with or without temperature control.
  • Choice of interchangeable laser blocks and wavelengths.

How it works

The Malvern NanoSight LM10 uses the technology of Nanoparticle Tracking Analysis (NTA). This unique technology utilizes the properties of both light scattering and Brownian motion in order to obtain the size distribution and concentration measurement of particles in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualized via a 20x magnification microscope onto which is mounted a camera. The camera operates at 30 frames per second (fps), capturing a video file of the particles moving under Brownian motion. The software tracks many particles individually and using the Stokes-Einstein equation calculates their hydrodynamic diameters.

Specification

General

Wavelength:
405nm (violet), 488nm (blue), 532nm (green) or 642nm (red).
Temperature control range:
Optional (5°C below ambient to 50°C).
Stage:
Manual stage.
Focus:
Manual focus.
Camera:
CCD or sCMOS.
Fluorescence:
Manual push/pull filter holder with 2 filters.
Dimensions (W, D, H):
420mm x 200mm x 260mm.
Particle size:
10nm to 2000nm.
Concentration range:
106 to 109 particles per mL.
Power:
100V - 240V

Accessories

NanoSight LM10

NanoSight syringe pump Image The Malvern NanoSight syringe pump is available for all Malvern NanoSight systems, enabling users to perform sample analysis at a constant flow rate. More information

Support

Protect your investment and ensure optimized performance at all times with Malvern’s service plans.

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern will provide the support for your business.

Help Desk

Training

Software downloads

Malvern’s service options- choose the right plan for you:

PlatinumMedal

Malvern Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.

GoldMedal

Malvern Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.

BronzeMedal

Malvern Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum PlanGold PlanBronze Visit
Annual PM/PV Test
yes
yes
no
Telephone / Email Support
yes
yes
no
Priority Response
yes
yes
no
Emergency Breakdown visits*
yes
yes
no
Parts Included
yes
no
no
Technical & Software Support
yes
yes
yes
IQ/OQ (Pharma)***
yes
yes
yes

*including labour & travel costs***available at an additional cost

 
 

Resource center search

Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

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Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products Webinar - Recorded (English)

Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...

Product:
Archimedes,Zetasizer range,Viscotek SEC-MALS,Morphologi G3-ID,NanoSight range
Date recorded:
September 20 2016
Language:
English


Enhancing NTA accuracy and repeatability with flow mode measurements Technical Note (English)

The standard measurement mode for Malvern’s NanoSight Nanoparticle Tracking Analysis (NTA) technique takes place with the sample static. In that case, the only motion in the analysis is the Brownian motion of the particles. Since NTA is a single-part...



Monitoring Microfiltration Processes for Water Treatment Application Note (English)

With the increasing demands on water supplies and tighter regulations, much research is being done on water treatment processes. Subjects of study include improving processes to allow treated water to be used in secondary applications, optimizing fil...



Adeno-Associated Viral Titer in minutes, using Nanoparticle Tracking Analysis (NTA) Webinar - Recorded (English)

• Nanoparticle Tracking Analysis (NTA) Characterization of Gold-Labeled Adeno Associated Virus (AAV) and Other Small Viruses • NTA is an analytical tool that measures the size and concentration of virus particles. • NTA can measure virus titer in abo...

Product:
NanoSight range
Date recorded:
June 7 2016
Language:
English


Case study: Using NTA to study nanoparticle diffusion Webinar - Recorded (English)

• Nanoparticle Tracking Analysis (NTA) was used to study the diffusion of silica nanoparticles functionalized with different polymers in aqueous solutions of water-soluble polymers and in dispersions of porcine gastric mucin • It was found that th...

Product:
NanoSight range
Date recorded:
May 24 2016
Language:
English

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Glossary

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Upcoming webinar

NanoSight NS300: Demo at your desk
(October 11 2016)

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