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The Malvern NanoSight NS300 Instrument provides an easy-to-use, reproducible platform for nanoparticle characterization.

The NS300 allows rapid, automated analysis of the size distribution and concentration of all types of nanoparticles from 10nm to 2000nm in diameter, depending on the instrument configuration and sample type.

With the ability to be supplied with interchangeable laser modules and theintroduction of a motorized 6 place filter wheel means different fluorescent labels can be analyzed.. Sample temperature is fully programmable through the Nanoparticle Tracking Analysis (NTA) software.


This versatile instrument offers the major benefit of a new enhanced fluorescence detection capability, providing truly holistic analysis. The 6 place fully software-controlled filter wheel means automated analysis of multiple fluorescent markers can be performed without the operator being present, freeing up valuable researcher time.

  • Simultaneous measurement of multiple characteristics, saving time and sample volume.
  • Visual validation of results gives extra confidence.
  • User friendly software with easy set up of SOPs for routine use.
  • Minimal sample preparation.
  • On board temperature control.
  • Choice of laser wavelengths.
  • Choice of up to 6 different filters in a motorized wheel provides flexible fluorescence detection capability.

How it works

The Malvern NanoSight NS300 uses the technology of Nanoparticle Tracking Analysis (NTA). This unique technology utilizes the properties of both light scattering and Brownian motion in order to obtain the size distribution and concentration measurement of particles in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualized via 20x magnification microscope onto which is mounted a camera. The camera operates at 30 frames per second (fps), capturing a video file of the particles moving under Brownian motion. The software tracks many particles individually and using the Stokes-Einstein equation calculates their hydrodynamic diameters.



405nm (violet), 488nm (blue), 532nm (green) or 642nm (red).
Temperature control range:
5°C below ambient to 50°C.
Fixed stage.
Computer controlled motorized focus.
Motorized 6 place filter wheel with choice of filters.
Dimensions (W, D, H):
400mm x 250mm x 400mm.
Particle size:
10nm to 2000nm.
Concentration range:
106 to 109 particles per mL.
100V - 240V


NanoSight NS300

NanoSight syringe pump Image The Malvern NanoSight syringe pump is available for all Malvern NanoSight systems, enabling users to perform sample analysis at a constant flow rate. More information


Protect your investment and ensure optimized performance at all times with Malvern’s service plans.

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern will provide the support for your business.

Help Desk


Software downloads

Malvern’s service options- choose the right plan for you:


Malvern Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.


Malvern Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.


Malvern Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum PlanGold PlanBronze Visit
Annual PM/PV Test
Telephone / Email Support
Priority Response
Emergency Breakdown visits*
Parts Included
Technical & Software Support
IQ/OQ (Pharma)***

*including labour & travel costs***available at an additional cost


Resource center search

Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

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A guide to technologies used for the analysis of particulates in injectable drugs Webinar - Live (English)

In recent years, the delivery of biological drugs via prefilled syringe-style devices has rapidly become more prevalent, in direct response to consumer demand. However, there are some challenges associated with this delivery method. One such challeng...

Archimedes,Morphologi G3-ID,NanoSight range,Zetasizer Nano range
November 29 2016

NanoSight NS300: Demo at your desk Webinar - Recorded (English)

This demo at your desk webinar will provide a real-time overview of the operation of the NanoSight NS300 for nanoparticle size and concentration measurements using Nanoparticle Tracking Analysis (NTA). You will see the instrument and software perform...

NanoSight NS300
Date recorded:
October 11 2016

Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products Webinar - Recorded (English)

Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...

Archimedes,Zetasizer range,Viscotek SEC-MALS,Morphologi G3-ID,NanoSight range
Date recorded:
September 20 2016

Enhancing NTA accuracy and repeatability with flow mode measurements Technical Note (English)

The standard measurement mode for Malvern’s NanoSight Nanoparticle Tracking Analysis (NTA) technique takes place with the sample static. In that case, the only motion in the analysis is the Brownian motion of the particles. Since NTA is a single-part...

Monitoring Microfiltration Processes for Water Treatment Application Note (English)

With the increasing demands on water supplies and tighter regulations, much research is being done on water treatment processes. Subjects of study include improving processes to allow treated water to be used in secondary applications, optimizing fil...

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Upcoming webinar

A guide to technologies used for the analysis of particulates in injectable drugs
(November 29 2016)

More information