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The Malvern NanoSight NS300 Instrument provides an easy-to-use, reproducible platform for nanoparticle characterization.

The NS300 allows rapid, automated analysis of the size distribution and concentration of all types of nanoparticles from 10nm to 2000nm in diameter, depending on the instrument configuration and sample type.

With the ability to be supplied with interchangeable laser modules and theintroduction of a motorized 6 place filter wheel means different fluorescent labels can be analyzed.. Sample temperature is fully programmable through the Nanoparticle Tracking Analysis (NTA) software.

Overview

This versatile instrument offers the major benefit of a new enhanced fluorescence detection capability, providing truly holistic analysis. The 6 place fully software-controlled filter wheel means automated analysis of multiple fluorescent markers can be performed without the operator being present, freeing up valuable researcher time.

  • Simultaneous measurement of multiple characteristics, saving time and sample volume.
  • Visual validation of results gives extra confidence.
  • User friendly software with easy set up of SOPs for routine use.
  • Minimal sample preparation.
  • On board temperature control.
  • Choice of laser wavelengths.
  • Choice of up to 6 different filters in a motorized wheel provides flexible fluorescence detection capability.

How it works

The Malvern NanoSight NS300 uses the technology of Nanoparticle Tracking Analysis (NTA). This unique technology utilizes the properties of both light scattering and Brownian motion in order to obtain the size distribution and concentration measurement of particles in liquid suspension. A laser beam is passed through the sample chamber, and the particles in suspension in the path of this beam scatter light in such a manner that they can easily be visualized via 20x magnification microscope onto which is mounted a camera. The camera operates at 30 frames per second (fps), capturing a video file of the particles moving under Brownian motion. The software tracks many particles individually and using the Stokes-Einstein equation calculates their hydrodynamic diameters.

Specification

General

Wavelength:
405nm (violet), 488nm (blue), 532nm (green) or 642nm (red).
Temperature control range:
5°C below ambient to 55°C.
Stage:
Fixed stage.
Focus:
Computer controlled motorized focus.
Camera:
sCMOS.
Fluorescence:
Motorized 6 place filter wheel with choice of filters.
Dimensions (W, D, H):
400mm x 250mm x 400mm.
Particle size:
10nm to 2000nm.
Concentration range:
106 to 109 particles per mL.
Power:
110V - 220V

Accessories

NanoSight NS300

NanoSight syringe pump Image The Malvern NanoSight syringe pump is available for all Malvern NanoSight systems, enabling users to perform sample analysis at a constant flow rate. More information

Support

Protect your investment and ensure optimized performance at all times with Malvern’s service plans.

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern will provide the support for your business.

Help Desk

Training

Software downloads

Malvern’s service options- choose the right plan for you:

PlatinumMedal

Malvern Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.

GoldMedal

Malvern Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.

BronzeMedal

Malvern Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum PlanGold PlanBronze Visit
Annual PM/PV Test
yes
yes
no
Telephone / Email Support
yes
yes
no
Priority Response
yes
yes
no
Emergency Breakdown visits*
yes
yes
no
Parts Included
yes
no
no
Technical & Software Support
yes
yes
yes
IQ/OQ (Pharma)***
yes
yes
yes

*including labour & travel costs***available at an additional cost

 
 

Resource center search

Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

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Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products Webinar - Live (English)

Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...

Product:
Archimedes,Zetasizer range,Viscotek SEC-MALS,Morphologi G3-ID,NanoSight range
Date:
September 20 2016
Language:
English


Adeno-Associated Viral Titer in minutes, using Nanoparticle Tracking Analysis (NTA) Webinar - Recorded (English)

• Nanoparticle Tracking Analysis (NTA) Characterization of Gold-Labeled Adeno Associated Virus (AAV) and Other Small Viruses • NTA is an analytical tool that measures the size and concentration of virus particles. • NTA can measure virus titer in abo...

Product:
NanoSight range
Date recorded:
June 7 2016
Language:
English


Case study: Using NTA to study nanoparticle diffusion Webinar - Recorded (English)

• Nanoparticle Tracking Analysis (NTA) was used to study the diffusion of silica nanoparticles functionalized with different polymers in aqueous solutions of water-soluble polymers and in dispersions of porcine gastric mucin • It was found that th...

Product:
NanoSight range
Date recorded:
May 24 2016
Language:
English


Nanobubbles: What are they, what are their uses and how can I measure them? Webinar - Recorded (English)

The area of fine and ultrafine bubble technology has seen great advancements over the last few years. Ultrafine bubble water has become used in a great deal of cleaning processes (salt, oil, dirt) and also finds uses in hydroponics, ozonation of wate...

Product:
NanoSight range
Date recorded:
May 19 2016
Language:
English


Evaluating aggregation behavior of liposome-protein complexes using NTA Whitepaper (English)

Aggregation of both biological and synthetic materials is a serious cause for concern, posing problems at various stages of the discovery and formulation processes. Liposomes have been used in drug discovery and drug delivery for some time, and the b...


Previous page Showing results 1 - 5 of 87 Next page

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Upcoming webinar

Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products
(September 20 2016)

More information