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Malvern’s OMNISEC is a complete Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) solution consisting of systems, detectors and software. It includes OMNISEC RESOLVE, the integrated separations module, OMNISEC REVEAL, the integrated multi-detector module and OMNISEC software for advanced GPC/SEC analysis.
In OMNISEC, Malvern's expertise has enabled the development of the most sensitive and accurate multi-detector GPC/SEC system available for the characterization of synthetic and natural polymers, and proteins.
OMNISEC RESOLVE combines an integrated pump, degasser, autosampler and column oven in a single advanced separations unit.
OMNISEC REVEAL is the most advanced integrated GPC/SEC multi-detector available, incorporating refractive index, UV/Vis absorbance, light scattering and intrinsic viscosity detectors.
Dissolved gasses are removed from the mobile phase as the pump draws it through the degasser before sending it onwards to the autosampler and column oven. The autosampler draws sample from either a vial or a microtiter plate and injects it into the mobile phase which then continues to the column. As the dissolved sample flows through the porous column matrix, the individual molecules diffuse in and out of the pores. Since larger molecules are excluded from more pores, they will travel through the column faster and elute earlier while the smaller molecules elute later. The result is a separation by hydrodynamic size for measurement by the detectors.
<0.3% RSD in full loop mode
<0.5% RSD in partial loop mode
<1% RSD in µL pickup mode
US20140060162A1 & EP2619543Ba "Modular capillary bridge viscometer"
US20140144214A1 & EP2619544A1 "Automatically balanced capillary bridge viscometer"
When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Some customers just need to ask an occasional question or to download a software upgrade, whilst others require a comprehensive support contract with priority call out and fixed cost of ownership. Whatever your situation Malvern will provide the right support for you.
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In this work three commercially available Low Molecular Weight Heparin samples (Enoxaparin, Tinzaparin and Dalteparin) are measured by triple-detection GPC and any differences identified. In addition, structural comparisons will be made with a commer...
A variety of aqueous (water-soluble) cellulose derivatives were characterized using the OMNISEC triple detection GPC/SEC system which revealed subtle, yet distinct differences between them. The differences described in this application note could be ...
Two antibody samples were characterized using column calibration and multi-detection SEC, and the results compared to show how multi-detection SEC provides more accurate data and a more complete characterization of the protein mixtures under study.
Using OMNISEC, we will show how to separate the effects of a structural difference induced by a compositional change to a polymer (e.g. substitution) and the structural change induced by polymer chain branching.
In this application note, a selection of different PLA and PLGA polymer samples were analyzed on Malvern's OMNISEC GPC/SEC system, which combines multiple detectors to provide information about structure and solution properties.
(Webinar - Recorded)
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