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OmniSEC software is at the heart of all Viscotek systems, providing an integrated solution that helps you maximize the information and efficiency of your experiments. Simply load your samples and the software controls all the sequencing, enabling truly automatic unattended operation.

Overview

OmniSEC contains many convenient and productive features, and supports the following:

  • Multi detection (Single/Dual/Triple/Tetra).
  • Absolute molecular weight.
  • Protein analysis.
  • Molecular conformation/branching.
  • Copolymer analysis.
  • Mark-Howink Plots.
  • Flow Injection Polymer Analysis (FIPA).
  • Universal calibration.
  • Conventional calibration.

Key Benefits:

  • Two clicks from raw data to results.
  • Built-in, intuitive report designer.
  • Manual or fully automatic baseline setting.
  • Automatic determination of dn/dc, UV extinction coefficient and A2.
  • Proven asymmetric band broadening corrections.
  • Fully automatic process control/LIMS mode.
  • Integrated help system to guide users.
  • Full export capability of raw data, results and intermediate calculations.
  • Enables compliance with 21 CFR part 11.

How it works

OmniSEC gives direct control of any Viscotek instrument, as well as the ability to acquire and display results in real time.

After installing the software on a suitable PC, a serial cable is used to connect the computer to any Viscotek instrument. OmniSEC then performs an automatic search to detect any connected devices (such as the TDA 305 or GPCmax) and select appropriate COM ports.

After completion of this process, the user is able to control the instruments, change detector settings and set up new or existing analysis methods. At the end of the run, data can be analyzed and reports automatically generated.

Specification

Specification

Complete GPC/SEC system including Conventional, Universal, Light Scattering, Triple, Copolymer, Protein specific, and FIPA calculation modules

Output of Mn, Mw, Mz, Mp, Mw/Mn, IV [η], Rh, Rg, Branching Number, Branching Frequency , Weight Fraction, Concentration, MH-a, MH-k, dn/dc, dA/dc. A2

Data acquisition rate:
6 channels, 5Hz, unlimited acquisition time
Calculation modules:
M<sub>n</sub>, M<sub>w</sub>, M<sub>z</sub>, M<sub>p</sub>, M<sub>w</sub>/M<sub>n</sub>, IV [η], R<sub>h</sub>, R<sub>g</sub>, Branching Number, Branching Frequency, Number of Arms, Weight Fraction, Concentration, MH-a, MH-k, dn/dc, dA/dc. A<sub>2</sub>
Results output:
 
 

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Characterization of Whey Protein Isolate (WPI) using multi-detector size-exclusion chromatography Application Note (English)

In this application note, a sample of Whey Protein Isolate (WPI) was characterized using the Viscotek TDAmax. The 4 main components in this mixture were separated and individually characterized to determine molecular weight and size. ...


Keywords: English Application Note Molecular size Molecular weight Size Exclusion Chromatography Dairy products Food additives Protein aggregation Proteins Viscotek TDAmax Viscotek TDA 305 

Using Multi-Detection GPC/SEC to Determine Impact of Sterilization on Medical-Grade Polymers Article (English)

This article gives an introduction to multi-detection GPC/SEC and presents data that shows how the technique is being used to determine the impact of sterilization on medical grade poly(L-lactide).


Keywords: Polymer solutions English Article Molecular structure Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Specialty and novel polymers Injectables Viscotek TDAmax 

Viscotek 350 HT-GPC user manual (English) User Manual (English)

User manual for the Viscotek 350 HT-GPC used with Gel Permeation Chromatography/Size Exclusion Chromatography (GPC/SEC) systems


Keywords: English User Manual Viscotek systems Viscotek HT-GPC Viscotek detectors 

Characterization of hydrodynamic changes upon cation-binding to proteins Application Note (English)

Cations are specifically recognized by numerous proteins. Despite their small size, their specific interactions with highly charged residues allow them to induce significant conformational changes on their binding proteins. The protein conformational...


Keywords: English Application Note Molecular size Molecular weight Zeta potential Electrophoretic Light Scattering Size Exclusion Chromatography Viruses and vaccines Zetasizer Nano ZS Proteins Protein mobility Biological drug characterization and development Viscotek TDAmax Viscotek TDA 305 

PEGylated proteins: Optimizing conjugation reactions using triple detection SEC Application Note (English)

In this application note, interferon α-5 was conjugated with two different PEG molecules in different reactions. The individual protein and PEG molecules, as well as the PEGylated conjugates are characterized by SEC and their composition,...


Keywords: English Application Note Molecular size Molecular weight Static Light Scattering Size Exclusion Chromatography Protein aggregation Proteins Biological drug characterization and development Viscotek TDAmax Viscotek SEC-MALS Viscotek UV-PDA Detector (2600) 
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