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The Viscotek TDAmax is a complete stand-alone, research grade, temperature controlled, multi-detector GPC/SEC system suitable for the molecular weight and molecular size determination of proteins, natural and synthetic polymers, copolymers and other macromolecules.


The TDAmax consists of three components – the GPCmax integrated solvent and sample delivery module, the TDA 305 Triple Detector Array, and the OmniSEC software. The TDA 305 incorporates RI and, Light Scattering detectors, as well as a viscometer and optional UV detector. Both the integrated detectors and the chromatography columns are fully temperature controlled in an oven to ensure optimum detector stability. In addition, the detectors are connected in series to ensure maximum sensitivity.

  • Absolute molecular weight of small polymers, protein stability and protein aggregation using Right angle light scattering (RALS)
  • Direct output of absolute molecular weight of polymers without extrapolation using Low angle light scattering (LALS)
  • Protein and polymer structure (including branching) information using intrinsic viscosity detector
  • Molecular size in terms of hydrodynamic diameter (Rh) and the radius of gyration (Rg)
  • Copolymer composition using photo-diode array UV detector
  • Autosampler incorporated to increase throughput and improve repeatability
  • Advanced GPC/SEC software capable of going from data to results in just two clicks
  • 3D absorption plot for chemical identification of each component
  • 21 CFR part 11 compliant
  • Full suite of calibration and GPC/SEC calculation types

How it works

The GPCmax contains an integrated pump, autosampler and degasser. Mobile phase, stored in solvent bottles placed on top of the instrument, enters the dual piston pump after passing through the eluent sensor. This will automatically stop the flow if the solvent is exhausted mid-run. An inline degasser then removes dissolved gases from the mobile phase, which improves the baseline on any of the detectors that may be connected. The pump is compatible with any solvent, even acidic buffers.

The autosampler inside the GPCmax can hold up to 120 vials, which can either be heated, or cooled to prevent degradation of the samples over time. The Autosampler provides the system with variable, reliable, accurate and reproducible injection volumes, enabling comprehensive macromolecular characterizations to be made with confidence.

Mobile phase (and sample) enters the TDA and passes through the GPC/SEC chromatography columns. The columns are maintained at the same temperature as the detectors. After eluting from the column, the dissolved polymer molecules, now separated by size, pass through the UV detector (if present), followed by the light scattering and RI detectors. Finally, the mobile phase passes through the viscometer before going to waste.



Pump flow rate:
0.01 to 9.99 mL/min, programmable soft start
Less than 1%, measured with viscometer
Two channels, < 0.5ppm oxygen at ) 0.5mL/min, eluent sensor to stop pump when eluent runs out
Dimensions (W, D, H):
55cm x 53cm x 38cm
OmniSEC, 6 channels at 5Hz, unlimited acquisition time


120 vials, programmable sequence
Injection volume:
Variable 20 to 150µL
Better than 0.5%
Less than 0.1%, depending on wash program
Cooling option:
4°C to 40°C, limited to 60 vials
Heated tray option:
Up to 65°C limited to 60 vials heated, 60 vials unheated


Temperature range:
Ambient to 80°C, all detector cells and columns
Column capacity:
Up to 5 x 30cm columns
6 channel digital to OmniSEC software, 2 analogue inputs RI and UV/LS
Dimensions (W, D, H):
41cm x 54cm x 28cm

Detector 1

Light scattering
Measurement principle:
RALS 90° angle, LALS 7° angle
Light source:
3mW laser diode, 670nm, temperature controlled
Cell volume:
Data acquisition rate:
100Hz collection, 5Hz to OmniSEC

Detector 2

Refractive index
Measurement principle:
Light source:
Cell volume:
Data acquisition rate:
100Hz collection, 5Hz to OmniSEC

Detector 3

Measurement principle:
4 capillary differential Wheatstone bridge configuration
Digital Inert Transducers with over-pressure protection
Cell volume:
Data acquisition rate:
100Hz collection, 5Hz to OmniSEC

Detector 4 (option)

UV, Single wavelength programmable
190 to 740nm
Light source:
Deuterium, Tungsten halogen optional
Cell volume:
Data acquisition rate:
Analog, A-to-D with 5Hz to OmniSEC

Detector 5 (option)

190 to 500nm or 710nm on 256 diode array
Light source:
Deuterium (190 – 500nm), Tungsten halogen (430 – 710nm)
Cell volume:
Data acquisition rate:
256 channels with 1Hz to OmniSEC
Laser safety:
Class 1

Operating environment

15°C – 40°C
35% - 80% non-condensing


Viscotek TDAmax

Viscotek GPCmax Integrated Pump, Autosampler and Degasser, perfect for size exclusion and gel permeation chromatography. Image The GPCmax is a solvent and sample delivery module exclusively for GPC/SEC applications. It provides the reliable and stable chromatographic foundation for the Viscotek advanced detection systems. More information
Viscotek TDA 305 The standard for GPC/SEC with integrated refractive index viscometer and light scattering detectors. Image Research grade temperature controlled GPC/SEC detector module to measure sample concentration, molecular weight and intrinsic viscosity. The TDA is ideal for characterizing synthetic and natural polymers and proteins.
Viscotek UV-PDA Detector Concentration detector, perfect for GPC/SEC, molecular weight determination and compositional analysis. Image Accurate measurement of the polymer or protein concentration profile is essential to good molecular weight or structure data. The high-stability Viscotek UV-PDA detector is ideally suited for multi-detection GPC/SEC. More information
OmniSEC software Powerful, agile, easy to use GPC/SEC software for instrument control, data acquisition, analysis and reporting. Image OmniSEC software is an integrated solution for the advanced analysis of proteins and polymers by GPC/SEC, and is at the heart of all Viscotek systems and detectors. Selectable "protein" or "polymer" user interfaces with simplified work flows improve productivity and help you to maximize the information and efficiency of your experiments. Simply load your samples and the software controls all the sequencing, enabling truly automatic unattended operation. More information
GPC and SEC Columns GPC/SEC columns for all aqueous and organic applications Image A wide range of columns for analytical GPC/SEC of synthetic and natural polymers and proteins. More information
GPC and SEC Standards A range of molecular weight standards for different applications of GPC/SEC Image Malvern offers a wide range of molecular weight standards for GPC/SEC for conventional and universal calibration as well as light scattering. More information


When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Some customers just need to ask an occasional question or to download a software upgrade, whilst others require a comprehensive support contract with priority call out and fixed cost of ownership. Whatever your situation Malvern will provide the right support for you.

Help Desk

  • Telephone and email support.
  • Operators who take responsibility for your call and ensure your query is answered.


  • On Site training courses
  • Classroom training
  • E-learning

Resource Centre

  • Application notes
  • Technical notes
  • On demand presentations
  • Live webinars

Software Downloads

  • A simple mechanism for receiving updates and new features

Platinum and Gold Service Contracts:

  • Protection from the cost of downtime
  • No time lost in obtaining help when you need it
  • Fixed cost of ownership

Bronze Service Agreements:

  • Protect the value of your investment
  • Reduce the risk of downtime
  • Protect the validity of your data

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The Benefits of Multi-Detector SEC for Protein Analysis Article (English)

Using a light scattering detector as part of a multi-detector Size Exclusion Chromatography system provides the accurate molecular weight (MW) data needed to assess the activity, safety and clinical efficacy of therapeutic proteins.

Keywords: English Article Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Protein aggregation Proteins Biopharmaceutical development Viscotek TDAmax Viscotek TDA 305 

An investigation into the effects of aging on automotive bumper samples by xylene soluble flow injection polymer analysis (XS-FIPA) Poster (English)

This poster describes the use of flow injection polymer analysis (FIPA) as an analytical tool for xylene soluble (XS) determination with quick and easy simultaneous measurements of molecular weight (MW), intrinsic viscosity (IV) and XS%. The techniqu...

Keywords: Polymer solutions English Poster Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Automotive and aerospace Viscotek TDAmax 

Characterization of proteins and protein self-association (ologomerization) with SEC-MALS Poster (English)

In this poster, a series of proteins and their oligomers were characterized using SEC-MALS with UV and RI detection. The monomer and oligomer molecular weights are measured and compared with those from column calibration and the differences explored....

Keywords: English Poster Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Proteins Biopharmaceutical development Viscotek TDAmax Viscotek SEC-MALS 

The use of triple detection GPC to determine absolute molecular and structural information about low molecular weight heparins Poster (English)

In this work three commercially available Low Molecular Weight Heparin samples (Enoxaparin, Tinzaparin and Dalteparin) are measured by triple-detection GPC and any differences identified. In addition, structural comparisons will be made with a commer...

Keywords: English Poster Molecular structure Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Pharmaceutical development Viscotek TDAmax Viscotek TDA 305 

Nanoparticle size characterization: Tips and Tricks Webinar - Recorded (English)

Nanoparticles are defined by their size. In this presentation different sizing techniques are compared, with a focus on experimental tips and tricks to get maximum value from sizing techniques such as dymamic light scattering with the Malvern Zetasiz...

Zetasizer Nano range,Viscotek systems
Date recorded:
November 11 2014

Keywords: English Dynamic Light Scattering Webinar - Recorded Eastern Time Zetasizer Nano range Viscotek systems 
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