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The Malvern Zetasizer series measures particle and molecule size from below a nanometer to several microns using dynamic light scattering, zeta potential and electrophoretic mobility using electrophoretic light scattering, and molecular weight using static light scattering. In addition the system can be connected to a GPC / SEC system to use as a chromatography detector. The system is available in a range of variants that allows you to select the best system for your application and budget, and the philosophy of the design is to ensure exceptional ease of use and give confidence in the results without compromising performance.
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Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...
Samples for zeta potential measurements need to be optically clear and may require dilution. The way in which the dilution is performed is absolutely critical in determining the zeta potential value measured.
Multiple scattering refers to the phenomenon where photons scattered from the sample are re-scattered from neighboring particles prior to reaching the instrument detector.
Number fluctuations are defined as variations in the number of particles within the scattering volume during the course of a dynamic light scattering (DLS) measurement.
Electroosmosis is the movement of a liquid relative to a stationary charged surface under the influence of an applied voltage
Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products
(September 20 2016)
Nanoparticle size is an important criterion for our formulations and we routinely measure this with the Zetasizer Nano.
My students have always had great things to say about the Zetasizer Nano. They say it’s very easy to use. The software is very user-friendly and it can accommodate particles of various different sizes, so I have never had reason to evaluate another particle sizing instrument.
Dr. Albena Ivanisevic
Department of Materials Science and Engineering at North Carolina State University
On-line zeta potential measurement is helping us to achieve a more cost-efficient water facility.
The Zetasizer Nano is so easy to use. All my students can familiarise themselves with it very quickly. As a result, we are purchasing a second instrument to ensure we have enough capacity for our expanding research programme in this area.
Department of Chemistry, at The University of Sheffield
Here at IU’s Nanocharacterization facility, the Malvern Zetasizer Nano is the ‘go to’ instrument for characterization of assembled product.
Dr Stella Aniagyei
Indiana University’s (IU) Molecular and Cellular Biochemistry Department
We very much value the customer service and training opportunities from Malvern. In particular, the rapid diagnosis of any issues through direct internet connection with the Malvern customer service team has prevented us from suffering production downtime.
Dr. Cordula Grüttner
micromod Partikeltechnologie GmbH
The big plus of an on-line instrument is real-time monitoring, the value of which was really brought home to us during a recent treatment event. The on-line data we collected during the event gave us new insight into a modified operating scheme that we’re now capitalizing on.
The Malvern systems have proved highly effective, allowing us to further demonstrate the stability and purity of our products and how this may be translated into improving liquid biopharmaceutical formulations.
We’ve always been really happy with Malvern and while we’ve tried other companies, the necessary expertise was not there.
the IN-CTSI (Indiana-Clinical Translational Sciences Institute)
We have had several researchers become new NRC users because they want to access our Malvern Zetasizer Nano
the Nanotechnology Research Center (NRC) at the Georgia Institute of Technology
The [Zetasizer Nano] instrument is robust, easy to use and data acquisition is straightforward. It is as close to ‘student proof’ as it is possible to be!
Dr Krystelle Mafina
Queen Mary University
The technical support that we’ve received has been a deciding factor in our decision to continue to work with Malvern. Malvern systems also provide the cutting-edge performance and reliability that we need.
Domino Printing Sciences plc
The Zetasizer Nano has reliably delivered a substantial portion of data and continues to help drive our research.
As part of the multi-disciplinary lab at QMUL, materials and biomaterials research groups throughout the university, from engineers and chemists through to biologists and physicists, are benefiting from access to analysis using the Zetasizer Nano.
We’ve been running the Zetasizer APS continuously since 2012 and the real beauty is that we simply load the samples in multiwell plates, leave it to run, even overnight, and go back and pick up the results.
Dr Maria Håkansson
All information supplied within is correct at time of publication.
Malvern Instruments pursues a policy of continual improvement due to technical development. We therefore reserve the right to deviate from information, descriptions, and specifications in this publication without notice. Malvern Instruments shall not be liable for errors contained herein or for incidental or consequential damages in connection with the furnishing, performance or use of this material.
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