The Zetasizer Nano Z is the perfect system for measuring zeta potential and electrophoretic mobility of colloids and nanoparticles, when the measurement of size or molecular weight is not required.
- Zeta potential using patented M3-PALS technology.
- A ‘Quality Factor’ and ‘Expert Advice System’ gives the confidence of having an expert at your shoulder.
- 21CFR part 11 software option to enable compliance with ER/ES.
- Research software option to give access to further features and analysis algorithms for the light scattering specialist.
- Automation of measurements using an autotitrator option.
- Alternative laser, 50mW at 532nm for samples incompatible with the standard 633nm laser.
- Optical filter option to improve measurements with fluorescent sample.
- Temperature range extension option to 120°C.
The Zetasizer Nano Z uses micro-electrophoresis / electrophoretic light scattering technology to measure zeta potential and electrophoretic mobility.
Laser Doppler Micro-electrophoresis is used to measure zeta potential. An electric field is applied to a solution of molecules or a dispersion of particles, which then move with a velocity related to their zeta potential. This velocity is measured using a patented laser interferometric technique called M3-PALS (Phase analysis Light Scattering). This enables the calculation of electrophoretic mobility, and from this, the zeta potential and zeta potential distribution.
The software is designed to be versatile and rich in features without compromising ease of use. Standard Operating Procedures (SOP) simplify routine measurements, a quality factor gives a single place for confirmation of data quality, and an expert advice system is provided to assist with data interpretation.
The MPT-2 Autotitrator enables the study of the effect of changes in pH, conductivity, or any additive to be automated.
A range of disposable and reusable cells are available to optimize the measurement in terms of sample volume, concentration and flow measurement.
Other options include filters to improve the measurement of fluorescent samples, a temperature range extension to 120ºC and a viscometer to determine the sample viscosity to the accuracy required for the techniques used.
- Measurement range:
- 3.8nm – 100 microns* (diameter)
- Measurement principle:
- Electrophoretic Light Scattering
- Minimum sample volume:
- 150µL (20µL using diffusion barrier method).
- 0.12µm.cm/V.s for aqueous systems using NIST SRM1980 standard reference material.
- 10mg/mL (BSA)
- Temperature control range:
- 0°C - 90°C +/-0.1**, 120°C option.
- Light source:
- He-Ne laser 633nm, Max 4mW.
- Laser safety:
- Class 1
Weight and dimensions:
- Dimensions (W, D, H):
- 320mm, 600mm, 260mm (W,D,H)
- 21 kg
- Operating temperature (°C):
- 10°C – 35°C
- 35% - 80% non-condensing
- maximum range, sample dependent
- at 25°C.
- The Zetasizer Nano range is protected by the following patents:
Non-Invasive Back Scatter (NIBS)
EP884580, US6016195, JP11051843
High and Low Frequency Electrophoreses (M3)
EP1154266, US7217350, JP04727064
Light Scattering Measurements using Simultaneous Detection
EP2235501, CN102066901, JP2011523451, US20090251696
Surface Potential Determination in a Dip Cell
A range of accessories are available to make life easier, or to add capability to the system
Simplify pH, conductivity and additive titrations on your Zetasizer Nano
A cost effective accessory designed to automate the measurement of size and zeta potential as a function of pH, conductivity or any soluble additive.
Viscosity measurement with speed, simplicity and accuracy.
The SV-10 measures viscosity with the accuracy required for dynamic light scattering, for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential, in an extremely simple and rapid system.
Cell and cuvette options
Eliminate sample cross contamination between zeta potential measurements using a completely disposable cell.
The zeta potential of colloids and molecules is extremely sensitive to contamination from components of a previous sample used in a measurement cell. The use of a disposable cell completely eliminates this potential contamination issue.
The folded capillary cell provides the benefits of the accuracy of measurement of a capillary cell with the ease of use of a disposable cell.
Although, disposable, including the electrodes, for low conductivity samples each cell can be used for hundreds of measurements if required.
The cell can be used with the autotitrator, where multiple measurements are routinely done over a wide pH range.
Reusable solvent resistant cell.
The dip cell is used for the measurement of zeta potential of samples in aqueous and non-aqueous dispersants, and is designed to be cleaned and reused. It is for batch measurements using standard polystyrene or glass cuvettes.
Save time and effort by measuring zeta potential with little or no dilution.
The high concentration cell enables the measurement of the zeta potential of samples with little or no dilution in any Zetasizer Nano system that measures zeta potential.
The cell has a flow configuration so can be used for stop-flow size and zeta potential measurements using an MPT-2 autotitrator as well as batch measurements.
Extend the application of the Zetasizer Nano to measure the zeta potential of material surfaces.
The characterization of surfaces and interfaces is critical in a wide range of industries including consumer products, specialty chemicals, pharmaceuticals and life sciences. In each of these application areas, the interaction of molecules and particles with surfaces can influence the material properties of the end product.
The surface zeta potential accessory enables the measurement of the zeta potential of flat surfaces such as filter paper, silica, polymers and bone, using a standard Zetasizer Nano system.
Add flow capability for size measurements to the Zetasizer.
- Measure size and intensity with MPT-2 autotitrator.
- Connect to an SEC system to use as a DLS detector.
Glass cuvette for use with the dip cell.
- For size and zeta potential measurements using the ‘dip’ cell.
- Compatible with aqueous and non-aqueous solvents and dispersants.
Factory fitted options
For use where the sample is incompatible with the standard 633nm laser, either because the sample absorbs or fluoresces, or the sample is photosensitive.
This addition of this option does not affect the system specifications.
Useful where the sample fluoresces. Eliminates scattering due to fluorescence to improve the signal to background ratio.
Increases the high temperature capability from 90°C to 120°C. Suitable for samples in wax media that melt above 90°C.
Titrants used by the MPT-2 titrator need regular degassing, ideally before each titration.
Degassing is required to remove bubbles that can affect the volume of titrant dispensed. This is particularly important close to pH 7 where low volumes of titrant are required.
The degasser is a highly recommended ‘Fit and forget’ accessory that continuously degasses titrants which improves the speed of titrations and the accuracy of reaching the target pH. This gives more evenly spaced pH points.
Protect your investment and ensure optimized performance at all times with Malvern’s service plans.
When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern will provide the support for your business.
- A simple mechanism for receiving updates and new features
Malvern’s service options- choose the right plan for you:
Malvern Platinum Plan
For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.
Malvern Gold Plan
Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.
Malvern Bronze Visit
For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.
|Platinum Plan||Gold Plan||Bronze Visit|
|Annual PM/PV Test|
|Telephone / Email Support|
|Emergency Breakdown visits*|
|Technical & Software Support|
*including labour & travel costs** Platinum 2 places per contract term, Gold 1 place per contract term***available at an additional cost