Skip to left navigation

Skip to page content

Find us on...

The Zetasizer Nano Z system is dedicated to the measurement of zeta potential and electrophoretic mobility in aqueous and non-aqueous dispersions using Laser Doppler Micro-Electrophoresis.

Overview

The Zetasizer Nano Z is the perfect system for measuring zeta potential and electrophoretic mobility of colloids and nanoparticles, when the measurement of size or molecular weight is not required.

  • Zeta potential using patented M3-PALS technology.
  • A ‘Quality Factor’ and ‘Expert Advice System’ gives the confidence of having an expert at your shoulder.
  • 21CFR part 11 software option to enable compliance with ER/ES.
  • Research software option to give access to further features and analysis algorithms for the light scattering specialist.
  • Automation of measurements using an autotitrator option.
  • Alternative laser, 50mW at 532nm for samples incompatible with the standard 633nm laser.
  • Optical filter option to improve measurements with fluorescent sample.
  • Temperature range extension option to 120°C.

How it works

The Zetasizer Nano Z uses micro-electrophoresis / electrophoretic light scattering technology to measure zeta potential and electrophoretic mobility.

Laser Doppler Micro-electrophoresis is used to measure zeta potential. An electric field is applied to a solution of molecules or a dispersion of particles, which then move with a velocity related to their zeta potential. This velocity is measured using a patented laser interferometric technique called M3-PALS (Phase analysis Light Scattering). This enables the calculation of electrophoretic mobility, and from this, the zeta potential and zeta potential distribution.

Software
The software is designed to be versatile and rich in features without compromising ease of use. Standard Operating Procedures (SOP) simplify routine measurements, a quality factor gives a single place for confirmation of data quality, and an expert advice system is provided to assist with data interpretation.

Options
The MPT-2 Autotitrator enables the study of the effect of changes in pH, conductivity, or any additive to be automated.

A range of disposable and reusable cells are available to optimize the measurement in terms of sample volume, concentration and flow measurement.

Other options include filters to improve the measurement of fluorescent samples, a temperature range extension to 120ºC and a viscometer to determine the sample viscosity to the accuracy required for the techniques used.

Specification

Zeta potential

Measurement range:
3.8nm – 100 microns* (diameter)
Measurement principle:
Electrophoretic Light Scattering
Minimum sample volume:
150µL (20µL using diffusion barrier method).
Accuracy:
0.12µm.cm/V.s for aqueous systems using NIST SRM1980 standard reference material.
Sensitivity:
10mg/mL (BSA)
Temperature control range:
0°C - 90°C +/-0.1**, 120°C option.
Light source:
He-Ne laser 633nm, Max 4mW.
Laser safety:
Class 1
Power:
100VA

Weight and dimensions:

Dimensions (W, D, H):
320mm, 600mm, 260mm (W,D,H)
Weight:
21 kg

Operating environment:

Operating temperature (°C):
10°C – 35°C
Humidity:
35% - 80% non-condensing

Notes:

*:
maximum range, sample dependent
**:
at 25°C.
Patents:
The Zetasizer Nano range is protected by the following patents: Non-Invasive Back Scatter (NIBS) EP884580, US6016195, JP11051843 High and Low Frequency Electrophoreses (M3) EP1154266, US7217350, JP04727064 Light Scattering Measurements using Simultaneous Detection EP2235501, CN102066901, JP2011523451, US20090251696 Surface Potential Determination in a Dip Cell WO2012172330

Accessories

A range of accessories are available to make life easier, or to add capability to the system

Accessories

MPT-2 Simplify pH, conductivity and additive titrations on your Zetasizer Nano Image A cost effective accessory designed to automate the measurement of size and zeta potential as a function of pH, conductivity or any soluble additive. More information
SV-10 viscometer Viscosity measurement with speed, simplicity and accuracy. Image The SV-10 measures viscosity with the accuracy required for dynamic light scattering, for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential, in an extremely simple and rapid system. More information

Cell and cuvette options

Disposable folded capillary cell (DTS1070) Eliminate sample cross contamination between zeta potential measurements using a completely disposable cell. Image The zeta potential of colloids and molecules is extremely sensitive to contamination from components of a previous sample used in a measurement cell. The use of a disposable cell completely eliminates this potential contamination issue. The folded capillary cell provides the benefits of the accuracy of measurement of a capillary cell with the ease of use of a disposable cell. Although, disposable, including the electrodes, for low conductivity samples each cell can be used for hundreds of measurements if required. The cell can be used with the autotitrator, where multiple measurements are routinely done over a wide pH range. Visit store to buy now
Universal 'dip' cell kit Reusable solvent resistant cell. Image The dip cell is used for the measurement of zeta potential of samples in aqueous and non-aqueous dispersants, and is designed to be cleaned and reused. It is for batch measurements using standard polystyrene or glass cuvettes. Visit store to buy now
High concentration zeta potential cell kit Save time and effort by measuring zeta potential with little or no dilution. Image The high concentration cell enables the measurement of the zeta potential of samples with little or no dilution in any Zetasizer Nano system that measures zeta potential. The cell has a flow configuration so can be used for stop-flow size and zeta potential measurements using an MPT-2 autotitrator as well as batch measurements. Visit store to buy now
Surface zeta potential accessory Extend the application of the Zetasizer Nano to measure the zeta potential of material surfaces. Image The characterization of surfaces and interfaces is critical in a wide range of industries including consumer products, specialty chemicals, pharmaceuticals and life sciences. In each of these application areas, the interaction of molecules and particles with surfaces can influence the material properties of the end product. The surface zeta potential accessory enables the measurement of the zeta potential of flat surfaces such as filter paper, silica, polymers and bone, using a standard Zetasizer Nano system. Visit store to buy now
Quartz flow cell (ZEN0023) Add flow capability for size measurements to the Zetasizer. Measure size and intensity with MPT-2 autotitrator. Connect to an SEC system to use as a DLS detector. Visit store to buy now
12mm Glass cell (PCS1115) Glass cuvette for use with the dip cell. For size and zeta potential measurements using the ‘dip’ cell. Compatible with aqueous and non-aqueous solvents and dispersants. Visit store to buy now

Factory fitted options

50mW 532nm DPSS laser For use where the sample is incompatible with the standard 633nm laser, either because the sample absorbs or fluoresces, or the sample is photosensitive. This addition of this option does not affect the system specifications.
Narrow band filters Useful where the sample fluoresces. Eliminates scattering due to fluorescence to improve the signal to background ratio.
High temperature capability Increases the high temperature capability from 90°C to 120°C. Suitable for samples in wax media that melt above 90°C.
Degasser for MPT-2 autotitrator Titrants used by the MPT-2 titrator need regular degassing, ideally before each titration. Degassing is required to remove bubbles that can affect the volume of titrant dispensed. This is particularly important close to pH 7 where low volumes of titrant are required. The degasser is a highly recommended ‘Fit and forget’ accessory that continuously degasses titrants which improves the speed of titrations and the accuracy of reaching the target pH. This gives more evenly spaced pH points. Visit store to buy now

Support

Protect your investment and ensure optimized performance at all times with Malvern’s service plans.

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern will provide the support for your business.

Help Desk

Training

Software downloads

Malvern’s service options- choose the right plan for you:

PlatinumMedal

Malvern Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.

GoldMedal

Malvern Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.

BronzeMedal

Malvern Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum PlanGold PlanBronze Visit
Annual PM/PV Test
yes
yes
no
Telephone / Email Support
yes
yes
no
Priority Response
yes
yes
no
Emergency Breakdown visits*
yes
yes
no
Parts Included
yes
no
no
E-Learning**
yes
yes
no
Technical & Software Support
yes
yes
yes
IQ/OQ (Pharma)***
yes
yes
yes

*including labour & travel costs** Platinum 2 places per contract term, Gold 1 place per contract term***available at an additional cost

 
 

Resource center search

Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

Reset filters
Items shown: 5, 10, 20, ALL
Sort by: Date or Alphabetical
Previous page Showing results 1 - 5 of 265 Next page
How Do I Verify My Zeta Potential Instrument? FAQ

Electrophoretic light scattering (ELS) or zeta potential instruments use first principles in their measurement protocol. They cannot therefore, be calibrated. However, they can be verified that they are operating correctly, by measuring a suitable zeta potential standard.



How Do I Dilute My Samples For Zeta Potential Measurements? FAQ

Samples for zeta potential measurements need to be optically clear and may require dilution. The way in which the dilution is performed is absolutely critical in determining the zeta potential value measured.



What is Multiple Scattering? FAQ

Multiple scattering refers to the phenomenon where photons scattered from the sample are re-scattered from neighboring particles prior to reaching the instrument detector.



What is a Correlation Function (Correlogram)? FAQ

A correlation function shows the correlation coefficients plotted as a function of delay time



Number Fluctuations: What Are They and How Are They Recognised? FAQ

Number fluctuations are defined as variations in the number of particles within the scattering volume during the course of a dynamic light scattering (DLS) measurement.


Previous page Showing results 1 - 5 of 265 Next page

Glossary

Request a quote Request a demo Contact sales Register now Download brochure