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Dynamic light scattering (DLS), sometimes referred to as Quasi-Elastic Light Scattering (QELS), is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest technology lower than 1nm.

Typical applications of dynamic light scattering are the characterization of particles, emulsions or molecules, which have been dispersed or dissolved in a liquid. The Brownian motion of particles or molecules in suspension causes laser light to be scattered at different intensities. Analysis of these intensity fluctuations yields the velocity of the Brownian motion and hence the particle size using the Stokes-Einstein relationship.

Dynamic light scattering technology from Malvern Instruments offers the following advantages:

  • Accurate, reliable and repeatable particle size analysis in one or two minutes.
  • Measurement in the native environment of the material.
  • Mean size only requires knowledge of the viscosity of the liquid.
  • Simple or no sample preparation, high concentration, turbid samples can be measured directly.
  • Simple set up and fully automated measurement.
  • Size measurement of sizes < 1nm.
  • Size measurement of molecules with MW < 1000Da.
  • Low volume requirement (as little as 2µL).
  • Compliance with regulatory standards ISO 13321, ISO 22412, 21 CFR Part 11.

Related products

Zetasizer range The world's most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Zetasizer range - particle size, dynamic light scattering, zeta potential, protein aggregation
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
Particle size range
0.3nm to 10µm
Dispersion type
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
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A guide to technologies used for the analysis of particulates in injectable drugs Webinar - Live (English)

In recent years, the delivery of biological drugs via prefilled syringe-style devices has rapidly become more prevalent, in direct response to consumer demand. However, there are some challenges associated with this delivery method. One such challeng...

Archimedes,Morphologi G3-ID,NanoSight range,Zetasizer Nano range
November 29 2016

Controlling the dispersion or flocculation of colloidal suspensions through zeta potential Webinar - Recorded (English)

Many large scale industrial processes (paper production, water treatment and dewatering processes) require de-stabilization or flocculation of dispersed particulates. For other industries and products such as foods, cosmetics, paints and pharmaceutic...

Zetasizer range
Date recorded:
October 20 2016

Using the Zetasizer Nano to optimize formulation stability Whitepaper (English)

Formulation development is a critical activity for many industries, from pharmaceuticals, to paints and coatings. Indeed, it is estimated that in the UK alone, sales of formulated products amount to some £180 billion per year1. This means that gettin...

Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products Webinar - Recorded (English)

Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...

Archimedes,Zetasizer range,Viscotek SEC-MALS,Morphologi G3-ID,NanoSight range
Date recorded:
September 20 2016

Zeta potential - An important parameter for controlling formulation stability and product performance Webinar - Recorded (English)

Cosmetics, paints, inks, paper, drug delivery, personal care, food or intra-lipid emulsions are made up of multi component chemistries. Most products go through a stage where different phases co-exist such as emulsions, suspensions or dispersions and...

Zetasizer range
Date recorded:
September 8 2016

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A guide to technologies used for the analysis of particulates in injectable drugs
(November 29 2016)

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