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Dynamic light scattering (DLS), sometimes referred to as Quasi-Elastic Light Scattering (QELS), is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest technology lower than 1nm.

Typical applications of dynamic light scattering are the characterization of particles, emulsions or molecules, which have been dispersed or dissolved in a liquid. The Brownian motion of particles or molecules in suspension causes laser light to be scattered at different intensities. Analysis of these intensity fluctuations yields the velocity of the Brownian motion and hence the particle size using the Stokes-Einstein relationship.

Dynamic light scattering technology from Malvern Instruments offers the following advantages:

  • Accurate, reliable and repeatable particle size analysis in one or two minutes.
  • Measurement in the native environment of the material.
  • Mean size only requires knowledge of the viscosity of the liquid.
  • Simple or no sample preparation, high concentration, turbid samples can be measured directly.
  • Simple set up and fully automated measurement.
  • Size measurement of sizes < 1nm.
  • Size measurement of molecules with MW < 1000Da.
  • Low volume requirement (as little as 2µL).
  • Compliance with regulatory standards ISO 13321, ISO 22412, 21 CFR Part 11.

Related products

Zetasizer range The world's most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Zetasizer range - particle size, dynamic light scattering, zeta potential, protein aggregation
Measurement
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
90°C
Particle size range
0.3nm to 10µm
Dispersion type
Wet
Technology
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
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Suspension stability: Why particle size, zeta potential and rheology are important Webinar - Recorded (English)

Suspensions or dispersions of particles or droplets in a liquid medium are encountered in a variety of industries and find use in a diverse range of applications. These include liquid abrasives, ceramics, medicines, foodstuffs and inks to name a few....

Product:
Mastersizer range,Kinexus range,Zetasizer range
Date recorded:
February 11 2016
Language:
English


Size: What is the z-average? FAQ

The z-average diameter is the mean intensity diameter i.e. it is a diameter based upon the intensity of scattered light of a material in its native state (including electrical double layers and surface structure). The z-average is derived from a Cumulants analysis of the measured correlation curve, wherein a single particle size is assumed and a single exponential fit is applied to the autocorrelation function. It is unique to dynamic light scattering and it is sensitive to the presence of aggregates/dust due to the intensity of light scattered by any larger particles present.



Comparison of Statistical Measures Reported by NTA and DLS Techniques Technical Note (English)

As the Nanoparticle Tracking Analysis (NTA) technique has gained in popularity in recent years, comparison to Dynamic Light Scattering (DLS) results has become more frequent. When comparing results, it is important to understand the differences betwe...



Explaining the difference between Non-Invasive BackScatter (NIBS) and Backscatter – they are NOT the same. Technical Note (English)

The ability to measure accurate particle size across a range of concentrations and sizes whilst maintaining consistent results is critically important in ensuring you can trust your data and develop an understanding of your application. This paper he...



Nanoparticle Tracking Analysis (NTA) Application: Better Understanding Synthetic Nanoparticle Systems Webinar - Recorded (English)

This webinar introduces the Nanoparticle Tracking Analysis (NTA) technique and how it affords useful information in various synthetic nanoparticle systems. We will discuss how NTA was used to measure the effects of certain buffers on the aggregation...

Product:
NanoSight range
Date recorded:
November 17 2015
Language:
English

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