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Dynamic light scattering (DLS), sometimes referred to as Quasi-Elastic Light Scattering (QELS), is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest technology lower than 1nm.
Typical applications of dynamic light scattering are the characterization of particles, emulsions or molecules, which have been dispersed or dissolved in a liquid. The Brownian motion of particles or molecules in suspension causes laser light to be scattered at different intensities. Analysis of these intensity fluctuations yields the velocity of the Brownian motion and hence the particle size using the Stokes-Einstein relationship.
Dynamic light scattering technology from Malvern Instruments offers the following advantages:
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The z-average diameter is the mean intensity diameter i.e. it is a diameter based upon the intensity of scattered light of a material in its native state (including electrical double layers and surface structure). The z-average is derived from a Cumulants analysis of the measured correlation curve, wherein a single particle size is assumed and a single exponential fit is applied to the autocorrelation function. It is unique to dynamic light scattering and it is sensitive to the presence of aggregates/dust due to the intensity of light scattered by any larger particles present.
Suspensions or dispersions of particles or droplets in a liquid medium are encountered in a variety of industries and find use in a diverse range of applications. These include liquid abrasives, ceramics, medicines, foodstuffs and inks to name a few....
As the Nanoparticle Tracking Analysis (NTA) technique has gained in popularity in recent years, comparison to Dynamic Light Scattering (DLS) results has become more frequent. When comparing results, it is important to understand the differences betwe...
The ability to measure accurate particle size across a range of concentrations and sizes whilst maintaining consistent results is critically important in ensuring you can trust your data and develop an understanding of your application. This paper he...
This webinar introduces the Nanoparticle Tracking Analysis (NTA) technique and how it affords useful information in various synthetic nanoparticle systems. We will discuss how NTA was used to measure the effects of certain buffers on the aggregation...
(Webinar - Recorded)
Suspension stability: Why particle size, zeta potential and rheology are important
(February 11 2016)
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