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Dynamic light scattering (DLS), sometimes referred to as Quasi-Elastic Light Scattering (QELS), is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest technology lower than 1nm.

Typical applications of dynamic light scattering are the characterization of particles, emulsions or molecules, which have been dispersed or dissolved in a liquid. The Brownian motion of particles or molecules in suspension causes laser light to be scattered at different intensities. Analysis of these intensity fluctuations yields the velocity of the Brownian motion and hence the particle size using the Stokes-Einstein relationship.

Dynamic light scattering technology from Malvern Instruments offers the following advantages:

  • Accurate, reliable and repeatable particle size analysis in one or two minutes.
  • Measurement in the native environment of the material.
  • Mean size only requires knowledge of the viscosity of the liquid.
  • Simple or no sample preparation, high concentration, turbid samples can be measured directly.
  • Simple set up and fully automated measurement.
  • Size measurement of sizes < 1nm.
  • Size measurement of molecules with MW < 1000Da.
  • Low volume requirement (as little as 2µL).
  • Compliance with regulatory standards ISO 13321, ISO 22412, 21 CFR Part 11.

Related products

Zetasizer range The world's most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Zetasizer range - particle size, dynamic light scattering, zeta potential, protein aggregation
Measurement
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
90°C
Particle size range
0.3nm to 10µm
Dispersion type
Wet
Technology
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
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Combined DLS/Raman provides New Molecular Insights of Complex Fluids Article (English)

In particular, this article demonstrates the correlation between molecular changes (Raman Spectroscopy) and microstructural evolution of rheological properties (DLS, DLS-optical microrheology) for the first time for surfactant-based wormlike micellar...



Non-aqueous zeta potential measurements of carbon black powders Application Note (English)

The measurement of the zeta potential of non-aqueous suspensions is challenging as the electrophoretic mobility of the particles is very small. Here we describe how the Zetasizer Nano in combination with a universal dip cell accessory gives excellent...



Optimizing Small Volume DLS-Microrheology Measurements of Block Co-Polymers Used for Enhanced Oil Recovery Applications Application Note (English)

This note discusses how DLS-based optical microrheology can be used to determine the rheological behavior of polymer solutions and the impact of tracer particle chemistry on the measured microrheological response.



Suspension properties Masterclass 4: Using rheology to assess suspension stability Webinar - Recorded (English)

This presentation discusses the importance of particle size, zeta potential and rheology for a functional suspension, and demonstrates how these properties can be manipulated to induce dispersion stability.

Product:
Kinexus range,Zetasizer Nano range,Mastersizer range
Date recorded:
April 10 2013
Language:
English

Keywords: Suspensions, slurries and pastes English Kinexus range Mastersizer range Particle size Rheology and viscosity Zeta potential Dynamic Light Scattering Electrophoretic Light Scattering Webinar - Recorded Greenwich Time Zetasizer Nano range 

Protein stability measurements amplified: Combining SEC-MALS and DLS to maximize data output Application Note (English)

The stability of a protein sample and its tendency to aggregate is explored using a combination of SEC-MALS and DLS


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