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Dynamic light scattering (DLS), sometimes referred to as Quasi-Elastic Light Scattering (QELS), is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest technology lower than 1nm.

Typical applications of dynamic light scattering are the characterization of particles, emulsions or molecules, which have been dispersed or dissolved in a liquid. The Brownian motion of particles or molecules in suspension causes laser light to be scattered at different intensities. Analysis of these intensity fluctuations yields the velocity of the Brownian motion and hence the particle size using the Stokes-Einstein relationship.

Dynamic light scattering technology from Malvern Instruments offers the following advantages:

  • Accurate, reliable and repeatable particle size analysis in one or two minutes.
  • Measurement in the native environment of the material.
  • Mean size only requires knowledge of the viscosity of the liquid.
  • Simple or no sample preparation, high concentration, turbid samples can be measured directly.
  • Simple set up and fully automated measurement.
  • Size measurement of sizes < 1nm.
  • Size measurement of molecules with MW < 1000Da.
  • Low volume requirement (as little as 2µL).
  • Compliance with regulatory standards ISO 13321, ISO 22412, 21 CFR Part 11.

Related products

Zetasizer range The worlds most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Image
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
Particle size range
Dispersion type
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
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Polymer solution characterization – Part 4 Webinar - Recorded (English)

Polymeric materials are the most studied of all rheological materials and polymeric solutions in particular are perhaps the most interesting. They are ubiquitous in every-day life and play an important role in applications ranging from joint lubricat...

Zetasizer Nano ZS,Kinexus range,Rosand range,Zetasizer Nano ZSP,m-VROCi
Date recorded:
September 16 2014

Keywords: Polymer solutions English Kinexus range Rosand range Rheology and viscosity Dynamic Light Scattering Rheometry - capillary Rheometry - rotational Polymers, plastics and rubbers Paints, inks and coatings Food additives Webinar - Recorded Eastern Time Zetasizer Nano ZS Zetasizer Nano ZSP Microrheology m-VROCi Rheometry - microfluidic flow 

Getting the most out of Dynamic Light Scattering Article (English)

This article explores the benefits of fully automated, high throughput particle size and formulation stability measurements and presents data to show how a new autosampler for the widely used Zetasizer Nano particle characterisation syste...

Keywords: Films and coatings English Article Molecular size Particle size Dynamic Light Scattering Pigments and toners Paints, inks and coatings Colloids Zetasizer Nano S Zetasizer Nano S90 Zetasizer Nano ZS Zetasizer Nano ZS90 Zetasizer Nano ZSP 

Speed your way though your protein formulation screening by automating your measurements Webinar - Recorded (English)

The second virial coefficient (A2, B22) has been identified as a potential parameter to assess and optimize formulation stability. Traditionally, the measurement is time consuming in batch mode, since preparation of various concentrations...

Zetasizer APS
Date recorded:
August 26 2014

Keywords: English Dynamic Light Scattering Webinar - Recorded Eastern Time Zetasizer APS Biopharmaceutical development Biological drug characterization and development Bioformulation development 

Characterization of Single Wall Carbon Nanotubes (SWNTs) by combining Dynamic Light Scattering and Raman Spectroscopy Whitepaper (English)

The combination of DLS and Raman spectroscopy offers the ability to measure the length, diameter, and chirality of carbon nanotubes in a single experiment. These parameters can be used with existing empirical knowledge of nanotubes to pre...

Keywords: English Whitepaper Molecular structure Particle size Dynamic Light Scattering Raman spectroscopy Electronic displays Batteries Fuel cells Solar cells Carbon nanotubes Zetasizer Helix 

The Science of Beauty - Characterizing Hyaluronic Acid - the molecule behind anti-aging creams Webinar - Recorded (English)

Hyaluronic acid (HA) is a natural polysaccharide, that plays an important role in tissues, such as skin, tendons, muscles, and cartilage. As well as medical applications, It finds wide-spread use in cosmetics, particularly skin creams. In...

Viscotek TDAmax,Viscotek SEC-MALS,Zetasizer Nano ZS,Zetasizer Nano ZSP
Date recorded:
June 25 2014

Keywords: Polymer solutions English Molecular size Molecular weight Dynamic Light Scattering Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Cosmetics Personal care Specialty and novel polymers Webinar - Recorded Eastern Time Zetasizer Nano ZS Zetasizer Nano ZSP Microrheology Viscotek TDAmax Viscotek SEC-MALS 
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