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Dynamic light scattering (DLS), sometimes referred to as Quasi-Elastic Light Scattering (QELS), is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest technology lower than 1nm.
Typical applications of dynamic light scattering are the characterization of particles, emulsions or molecules, which have been dispersed or dissolved in a liquid. The Brownian motion of particles or molecules in suspension causes laser light to be scattered at different intensities. Analysis of these intensity fluctuations yields the velocity of the Brownian motion and hence the particle size using the Stokes-Einstein relationship.
Dynamic light scattering technology from Malvern Instruments offers the following advantages:
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The second virial coefficient (A2, B22) has been identified as a potential parameter to assess and optimize formulation stability. Traditionally, the measurement is time consuming in batch mode, since preparation of various concentrations...
The combination of DLS and Raman spectroscopy offers the ability to measure the length, diameter, and chirality of carbon nanotubes in a single experiment. These parameters can be used with existing empirical knowledge of nanotubes to pre...
Liposomes are fast becoming a preferred vehicle for delivering therapeutic drug molecules to target sites. This article discusses two techniques for the measurement of their size, concentration and zeta potential.
Spidroins are large, structural proteins that make up the bulk of spider silk fibres. This application note describes the use of a Zetasizer Nano ZSP to characterize their stability at different temperatures.
This webinar is of interest to anyone involved in the rheological testing of complex fluid formulations which are low viscosity and weakly-structured. DLS microrheology is a technique which is particularly applicable to polymers and prote...
(Webinar - Recorded)
Speed your way though your protein formulation screening by automating your measurements
(August 26 2014)
(Webinar - Live)
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