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Dynamic light scattering (DLS), sometimes referred to as Quasi-Elastic Light Scattering (QELS), is a non-invasive, well-established technique for measuring the size and size distribution of molecules and particles typically in the submicron region, and with the latest technology lower than 1nm.

Typical applications of dynamic light scattering are the characterization of particles, emulsions or molecules, which have been dispersed or dissolved in a liquid. The Brownian motion of particles or molecules in suspension causes laser light to be scattered at different intensities. Analysis of these intensity fluctuations yields the velocity of the Brownian motion and hence the particle size using the Stokes-Einstein relationship.

Dynamic light scattering technology from Malvern Instruments offers the following advantages:

  • Accurate, reliable and repeatable particle size analysis in one or two minutes.
  • Measurement in the native environment of the material.
  • Mean size only requires knowledge of the viscosity of the liquid.
  • Simple or no sample preparation, high concentration, turbid samples can be measured directly.
  • Simple set up and fully automated measurement.
  • Size measurement of sizes < 1nm.
  • Size measurement of molecules with MW < 1000Da.
  • Low volume requirement (as little as 2µL).
  • Compliance with regulatory standards ISO 13321, ISO 22412, 21 CFR Part 11.

Related products

Zetasizer range The worlds most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Image
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
Particle size range
Dispersion type
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
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Hit the Target Article (English)

Liposomes are fast becoming a preferred vehicle for delivering therapeutic drug molecules to target sites. This article discusses two techniques for the measurement of their size, concentration and zeta potential.

Keywords: Nanoparticles English Article Particle concentration Particle size Zeta potential Dynamic Light Scattering Electrophoretic Light Scattering Liposomes and micelles Zetasizer Nano range NanoSight range Nanoparticle Tracking Analysis 

Protein storage and stability analysis using the Zetasizer Nano ZSP Application Note (English)

Spidroins are large, structural proteins that make up the bulk of spider silk fibres. This application note describes the use of a Zetasizer Nano ZSP to characterize their stability at different temperatures.

Keywords: English Application Note Molecular size Dynamic Light Scattering Protein aggregation Proteins Zetasizer Nano ZSP Biological drug characterization and development Bioformulation development 

Probing low viscosity and weakly-structured complex fluid formulations using DLS microrheology Webinar - Recorded (English)

This webinar is of interest to anyone involved in the rheological testing of complex fluid formulations which are low viscosity and weakly-structured. DLS microrheology is a technique which is particularly applicable to polymers and prote...

Date recorded:
May 27 2014

Keywords: English Rheology and viscosity Dynamic Light Scattering Webinar - Recorded Eastern Time Microrheology 

Enhanced aggregate detection: monitoring protein stability using dual angle light scattering Application Note (English)

Forward scatter optics offer increased sensitivity for protein aggregates when combined with back-scatter measurements. This application note describes the use of dual angle light scattering to an Immunoglobulin G stability trial.

Keywords: English Application Note Particle size Dynamic Light Scattering Zetasizer Nano ZS Protein aggregation Proteins Zetasizer Nano ZSP Biopharmaceutical development 

Automate sample measurements & advance formulation development with the Zetasizer Nano Webinar - Recorded (English)

Automate particle size measurements for the Zetasizer Nano using the NanoSampler - a versatile, compact sample management accessory that precisely and reproducibly loads your samples into the Zetasizer Nano. Aut...

Zetasizer range
Date recorded:
May 15 2014

Keywords: English Zetasizer range Particle size Dynamic Light Scattering Webinar - Recorded GMT Time 
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