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Electrophoretic Light Scattering (ELS) is a technique used to measure the electrophoretic mobility of particles in dispersion, or molecules in solution. This mobility is often converted to Zeta potential to enable comparison of materials under different experimental conditions.

The fundamental physical principle is that of electrophoresis. A dispersion is introduced into a cell containing two electrodes. An electrical field is applied to the electrodes, and particles or molecules that have a net charge, or more strictly a net zeta potential will migrate towards the oppositely charged electrode with a velocity, known as the mobility, that is related to their zeta potential.

Malvern Instruments offer leading instrumentation for the measurement of electrophoretic mobility. The Zetasizer Nano provides a simple, fast and accurate way to measure zeta potential, and uses a unique disposable capillary cell to ensure that there is no cross contamination between samples. The NanoSight NS500 measures electrostatic potential particle-by-particle to produce number-weighted, not intensity-weighted, data, avoiding any bias towards larger particles.

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Zetasizer range The worlds most widely used system for nanoparticle, colloid and protein size, zeta potential and molecular weight measurements. Image
Molecular size, Particle size, Molecular weight, Zeta potential
Temperature range
Particle size range
0.3nm to 10µm
Dispersion type
Dynamic Light Scattering, Static Light Scattering, Size Exclusion Chromatography, Electrophoretic Light Scattering
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NanoSight NS500 Single particle zeta potential platform with integrated fluidics for automation. Image
Particle size, Particle concentration, Protein aggregation, Zeta potential
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10nm to 2000nm
Nanoparticle Tracking Analysis, Electrophoretic Light Scattering
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Suspension Stability: Why particle size, zeta potential and rheology are important Poster (English)

Why particle size, zeta potential and rheology are important. This poster discusses the importance of particle size, zeta potential and rheology for dispersion stability and how they can be manipulated to enhance stability

Keywords: Suspensions, slurries and pastes English Poster Particle size Rheology and viscosity Zeta potential Electrophoretic Light Scattering Laser diffraction Rheometry - rotational 

Challenges in the measurement of protein zeta potential Poster (English)

Research shows that aggregation of a protein sample that occurs during electrophoretic measurements is more likely to take place at the electrodes. A new measurement method, the Diffusion Barrier Technique, described in this poster protects the prote...

Keywords: English Poster Particle size Dynamic Light Scattering Electrophoretic Light Scattering Zetasizer Nano ZS Protein aggregation Proteins Zetasizer Nano ZSP Protein mobility Biopharmaceutical development 

Using Automated Light Scattering Measurements to Support Predictive Protein Formulation Screening Article (English)

High concentration, low-viscosity, stable therapeutic protein formulations are needed to enable low-volume parental administration. This article explores how a fully automated light scattering system supports the rapid screening of small volume sampl...

Keywords: Emulsions and creams English Article Bohlin Gemini 2 Kinexus pro+ Particle size Rheology and viscosity Zeta potential Dynamic Light Scattering Electrophoretic Light Scattering Rheometry - rotational Personal care Zetasizer Nano S Zetasizer Nano ZS Zetasizer Nano ZSP 

How good is on-line zeta-potential measurement in water treatment? Article (English)

In this article we look at what zeta potential is and the potential role that on-line zeta potential monitoring can play in optimizing the water treatment process, specifically flocculation control. The applicability of zeta potential is illustrated ...

Keywords: English Article Zeta potential Electrophoretic Light Scattering Water treatment Zetasizer Nano range 

Water treatment - Optimize coagulant dosing using zeta potential Webinar - Recorded (English)

Measure of particle charge is one of the key parameters used by water plant operators to evaluate the required amount of coagulant. This presentation discusses the use of zeta potential measurement and it's advantages as an absolute and s...

Zetasizer Nano range
Date recorded:
August 14 2014

Keywords: English Zeta potential Electrophoretic Light Scattering Water treatment Webinar - Recorded Eastern Time Zetasizer Nano range 
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