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Electrophoretic Light Scattering (ELS) is a technique used to measure the electrophoretic mobility of particles in dispersion, or molecules in solution. This mobility is often converted to Zeta potential to enable comparison of materials under different experimental conditions.
The fundamental physical principle is that of electrophoresis. A dispersion is introduced into a cell containing two electrodes. An electrical field is applied to the electrodes, and particles or molecules that have a net charge, or more strictly a net zeta potential will migrate towards the oppositely charged electrode with a velocity, known as the mobility, that is related to their zeta potential.
The velocity is measured by the laser Doppler technique. There are two implementations of this. One to determine a frequency shift, which can give a full zeta potential distribution and a second known as PALS, where the phase shift is measured. PALS is a more sensitive method, but only gives an average zeta potential value.
The Zetasizer Nano uses both techniques to give the best of both worlds.
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This application note compares the isoelectric point determined using the diffusion barrier technique against that obtained from other charge-measuring techniques. The data shown here shows very good agreement.
The Folded Capillary cell (DTS1070) is a maintenance-free, disposable capillary cell for size and zeta potential measurements in the Zetasizer Nano series of instruments. It is a replacement for DTS1060.
An introduction to the principles of froth flotation and the importance of the measurement of zeta potential
Measurements of the zeta potential of proteins were challenging due to their poor scattering and sensitivity to the measurement conditions. The Zetasizer Nano ZSP, and a novel measurement technique has made dramatic improvements in results
You've decided to measure the particle size of your product! However, there are so many techniques out there, which one are you going to use? This presentation will attempt to demystify the process of selecting the best analysis method.
10 Reasons that the zetasizer nano is chosen for scientific success
Sample measurements performed to demonstrate Zetasizer performance
Zetasizer Nano Z/ZS/ZS90 Specifications Zeta Potential Maximum Concentration Limit 40% w/v
Zetasizer Cells and Cuvettes: Descriptions and Uses
(Webinar - Recorded)
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