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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

Related products

Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.0003µm to 2µm
Dispersion type
Size Exclusion Chromatography, Dynamic Light Scattering
More information

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Using Multi-Detection GPC/SEC to Determine Impact of Sterilization on Medical-Grade Polymers Article (English)

This article gives an introduction to multi-detection GPC/SEC and presents data that shows how the technique is being used to determine the impact of sterilization on medical grade poly(L-lactide).

Keywords: Polymer solutions English Article Molecular structure Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Specialty and novel polymers Injectables Viscotek TDAmax 

Seal Wash Systems for GPCmax and VE-1122 Pumps – set up and operation Technical Note (English)

This technical note describes the two different ways of operating the seal wash system in the Viscotek GPCmax and VE-1122 pumps, which are essential for maximising the lifetime of seals and pistons.

Keywords: English Technical Note Gel Permeation Chromatography Size Exclusion Chromatography Viscotek 270max Viscotek RImax Viscotek TDAmax 

Overcoming the negative effect of protein structure on molecular weight measurement by Size Exclusion Chromatography – Two protein case studies with Anthrolysin and Bcl-2 Application Note (English)

A description of how advanced GPC/SEC detection can overcome inaccuracy in the measurement of molecular weight caused by deviation in the structure of the sample protein from that of the protein standards or interaction with the chromatography column...

Keywords: English Application Note Viscotek range Molecular structure Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Viruses and vaccines Protein aggregation Proteins 

Viscotek Column Selection Guide Technical Note (English)

The Viscotek range of GPC/SEC systems and detectors includes a wide selection of general and speciality columns for a wide range of applications. This technical note provides an introduction to the columns as well as providing some their technical de...

Keywords: Polymer solutions English Technical Note Viscotek range Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Polymers, plastics and rubbers Polysaccharides Proteins 

Columnas y Standares: Como hacer la correcta seleccion de las columnas y Standares para tu aplicacion de GPC/SEC Webinar - Recorded (Spanish)

Con una variedad de columnas para elegir, seleccionar las apropiadas asícomo los estándares para su aplicación GPC / SEC puede ser un reto. En este webinar, primero proporcionaremos una visión general de los tipos de columnas mas comunes ...

Viscotek range
Date recorded:
March 6 2014

Keywords: Viscotek range Gel Permeation Chromatography Size Exclusion Chromatography Webinar - Recorded Mexico Time Spanish 
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