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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.
When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.
By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.
For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:
From novel polymers to polymer formulations and additives, in applications from paints and coatings to foods and pharmaceuticals, Malvern offers a range of GPC systems or individual GPC detectors including SEC-MALS to suit your application needs.
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A defining feature of polysaccharides, which are used widely as food additives and for certain medical applications, is that they are naturally occurring and consequently prone to inherent variability. In this article we discuss how advanced gel perm...
Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a very popular analytical technique for characterizing natural and synthetic polymers. Malvern offers a range of multi-detector GPC systems for the advanced ch...
Investing in a new GPC/SEC system is a big decision with many factors to consider. This white paper lists the key items that you should think about when buying a new system and discusses the reasons for their importance. Finally, it discusses what M...
Correctly targeting a drug product’s delivery location and defining its release profile are critical challenges and the subject of a great deal of research. The role of polymers in drug delivery applications is growing, with particular emphasis on ta...
The drug delivery polymer polyglutamic acid was conjugated with different amounts of Doxorubicin and characterized using advanced multi-detector GPC to measure drug content, molecular weight and structure
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