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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

From novel polymers to polymer formulations and additives, in applications from paints and coatings to foods and pharmaceuticals, Malvern offers a range of GPC systems or individual GPC detectors including SEC-MALS to suit your application needs.

Related products

OMNISEC The world’s most advanced multi-detector GPC/SEC system molecular weight, molecular size, molecular structure, intrinsic viscosity by size exclusion chromatography with OMNISEC
Measurement
Molecular weight, Molecular size, Molecular structure
Molecular weight range
200Da to 10MDa
Minimum sample mass (polystyrene)
100ng
Minimum sample mass (BSA)
100ng
Technology
Size Exclusion Chromatography, Static Light Scattering, Gel Permeation Chromatography
More information
Viscotek SEC-MALS More angles, more data, more choice! molecular weight, molecular size, molecular structure, intrinsic viscosity by gel permeation chromatography with Viscotek
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation
Molecular weight range
1000Da to 10MDa
Minimum sample mass (polystyrene)
1µg
Minimum sample mass (BSA)
2µg
Technology
Gel Permeation Chromatography, Size Exclusion Chromatography, Static Light Scattering
More information
Viscotek range The leading multi-detector GPC/SEC systems and detectors. molecular weight, molecular size, molecular structure, intrinsic viscosity by gel permeation chromatography with Viscotek
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Molecular weight range
1000Da to 10MDa
Minimum sample mass (polystyrene)
1µg
Minimum sample mass (BSA)
1µg
Technology
Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Measurement
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.3nm to 2µm
Dispersion type
Wet
Technology
Size Exclusion Chromatography, Dynamic Light Scattering
More information
 
 

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Improving polymer performance: How adding a viscometer to your GPC system can help Webinar - Recorded (English)

Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is the gold standard in analysis of natural and synthetic polymers. Including a viscometer in your GPC system enables characterization of the structure of your po...

Product:
OMNISEC
Date recorded:
January 26 2016
Language:
English


History and development of Malvern GPC Viscometers Webinar - Recorded (English)

Gel Permeation Chromatography (GPC), also known as Size Exclusion Chromatography (SEC), is a very popular analytical toll for characterizing natural and synthetic polymers. The introduction of the first differential Viscometer (Viscotek Model H100) b...

Product:
Viscotek range,OMNISEC
Date recorded:
November 10 2015
Language:
English


General Instrument Care of the Viscotek TDAmax GPC/SEC system Technical Note (English)

This technical note details information about maintaining Viscotek GPC/SEC systems to maximize reliability, prevent damage, reduce downtime, recognise imminent issues and minimise service visits



From 0 to 60 – Novel polymer applications in the automotive industry Webinar - Recorded (English)

There is a strong global trend in automotive design that features a continuous increase in the use of conventional, performance, and novel polymeric materials. This is a result of weight savings, design flexibility, and ease of fabrication offered by...

Product:
Viscotek HT-GPC,Viscotek systems,Viscotek TDAmax,Viscotek DSV,Viscotek range
Date recorded:
September 3 2015
Language:
English


Principles of Triple Detection GPC/SEC Whitepaper (English)

Triple detection GPC/SEC combines measurements from multiple detectors to offer not only increased amounts of data, but also information, which is available thanks to the combination of different detectors and would not be obtainable using the indivi...


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