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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

Related products

Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.0003µm to 2µm
Dispersion type
Size Exclusion Chromatography, Dynamic Light Scattering
More information

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Seal Wash Systems for GPCmax and VE-1122 Pumps – set up and operation Technical Note (English)

This technical note describes the two different ways of operating the seal wash system in the Viscotek GPCmax and VE-1122 pumps, which are essential for maximising the lifetime of seals and pistons.

Keywords: English Technical Note Gel Permeation Chromatography Size Exclusion Chromatography Viscotek 270max Viscotek RImax Viscotek TDAmax 

Overcoming the negative effect of protein structure on molecular weight measurement by Size Exclusion Chromatography – Two protein case studies with Anthrolysin and Bcl-2 Application Note (English)

A description of how advanced GPC/SEC detection can overcome inaccuracy in the measurement of molecular weight caused by deviation in the structure of the sample protein from that of the protein standards or interaction with the chromatography column...

Keywords: English Application Note Viscotek range Molecular structure Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Viruses and vaccines Protein aggregation Proteins 

Columnas y Standares: Como hacer la correcta seleccion de las columnas y Standares para tu aplicacion de GPC/SEC Webinar - Recorded (Spanish)

Con una variedad de columnas para elegir, seleccionar las apropiadas asícomo los estándares para su aplicación GPC / SEC puede ser un reto. En este webinar, primero proporcionaremos una visión general de los tipos de columnas mas comunes ...

Viscotek range
Date recorded:
March 6 2014

Keywords: Viscotek range Gel Permeation Chromatography Size Exclusion Chromatography Webinar - Recorded Mexico Time Spanish 

From the applications laboratory: Using GPC/SEC to analyze elastomers Webinar - Recorded (English)

This webinar presents examples of GPC/SEC analysis of various elastomer chemistries and highlights the physical characterization information provided by this technique.

Viscotek range
Date recorded:
September 2 2013

Keywords: Polymer solutions English Viscotek range Molecular structure Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Polymers, plastics and rubbers Webinar - Recorded Greenwich Time 

Sample measurements to demonstrate the specifications of the Viscotek SEC-MALS 20 Technical Note (English)

The aim of this technical note is to show through a series of application examples, how the performance specifications of the Viscotek SEC-MALS 20 are derived.

Keywords: English Technical Note Viscotek range Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Viscotek SEC-MALS 
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