Skip to left navigation

Skip to page content

Find us on...

Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

Related products

OMNISEC The world’s most advanced multi-detector GPC/SEC system Image
Measurement
Molecular weight, Molecular size, Molecular structure
Temperature range
20°C to 65°C
Technology
Size Exclusion Chromatography, Static Light Scattering, Gel Permeation Chromatography
More information
Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Temperature range
25°C to 160°C
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Measurement
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.3nm to 2µm
Dispersion type
Wet
Technology
Size Exclusion Chromatography, Dynamic Light Scattering
More information
 
 

Resource center search

Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

Reset filters
Items shown: 5, 10, 20, ALL
Sort by: Date or Alphabetical
Previous page Showing results 1 - 5 of 145 Next page
OMNISEC for unsurpassed synthetic polymer characterization Webinar - Recorded (English)

Realize the maximum potential of your polymer using unsurpassed characterization of molecular weight and structure using OMNISEC – our latest gel permeation chromatography / size exclusion chromatography system. Dr. Mark Pothecary, Product Manager, ...

Product:
OMNISEC
Date recorded:
February 17 2015
Language:
English

Keywords: Polymer solids and melts Polymer solutions English Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Polymers, plastics and rubbers Polysaccharides Webinar - Recorded Eastern Time OMNISEC 

The use of triple detection GPC to determine absolute molecular and structural information about low molecular weight heparins Poster (English)

In this work three commercially available Low Molecular Weight Heparin samples (Enoxaparin, Tinzaparin and Dalteparin) are measured by triple-detection GPC and any differences identified. In addition, structural comparisons will be made with a commer...


Keywords: English Poster Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Polysaccharides Pharmaceutical development OMNISEC 

Analytical strategies for inkjet formulation – A customer perspective Webinar - Recorded (English)

Analytical systems from Malvern Instruments are now used routinely to advance inkjet formulation at Domino Printing Sciences plc in the UK, one of the world’s leading printing technology companies. Domino are best known for printing “sell-by” dates o...

Date recorded:
February 12 2015
Language:
English

Keywords: English Rheology and viscosity Dynamic Light Scattering Gel Permeation Chromatography Paints, inks and coatings Webinar - Recorded Eastern Time 

Accelerating the Development of Generic Pharmaceuticals: Developing an Analytical Toolkit Suitable for De-formulating Complex Reference Products Article (English)

In its report ‘Critical Path Opportunities for Generic Drugs’, the FDA emphasizes the need for advances in the field of analytical sciences in order to accelerate the development of generic products. Here, Paul Kippax highlights techniques that are e...


Keywords: Development English Article Chemical identification Molecular weight Particle shape Particle size Gel Permeation Chromatography Image analysis Raman spectroscopy Size Exclusion Chromatography Pharmaceutical formulation and development 

Understanding the effect of molecular weight and structure on the performance characteristics of cellulose derivatives using OMNISEC Application Note (English)

A variety of aqueous (water-soluble) cellulose derivatives were characterized using the OMNISEC triple detection GPC/SEC system which revealed subtle, yet distinct differences between them. The differences described in this application note could be ...


Keywords: Polymer solutions English Application Note Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Polymers from renewable sources Pharmaceutical development Excipients and coatings OMNISEC 
Previous page Showing results 1 - 5 of 145 Next page

Glossary

Contact sales Register now

Omnisec Launch

Playback the event