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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

Related products

Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
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Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.0003µm to 2µm
Dispersion type
Size Exclusion Chromatography, Dynamic Light Scattering
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Powerful protein SEC made simple! Webinar - Live (English)

This webinar will discuss how Malvern’s protein SEC measurement capabilities within the Viscotek range have developed and improved in the last year. We will also introduce the new features that are included in the latest release of OmniSEC, i...

Viscotek range,Viscotek RImax,Viscotek DSV,Viscotek 270max,Viscotek TDAmax,Viscotek SEC-MALS
September 30 2014

Keywords: English Viscotek range Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Webinar - Live Eastern Time Protein aggregation Proteins Biopharmaceutical development Viscotek 270max Viscotek DSV Viscotek RImax Viscotek TDAmax Viscotek SEC-MALS 

Using Multi-Detection GPC/SEC to Determine Impact of Sterilization on Medical-Grade Polymers Article (English)

This article gives an introduction to multi-detection GPC/SEC and presents data that shows how the technique is being used to determine the impact of sterilization on medical grade poly(L-lactide).

Keywords: Polymer solutions English Article Molecular structure Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Specialty and novel polymers Injectables Viscotek TDAmax 

The Science of Beauty - Characterizing Hyaluronic Acid - the molecule behind anti-aging creams Webinar - Recorded (English)

Hyaluronic acid (HA) is a natural polysaccharide, that plays an important role in tissues, such as skin, tendons, muscles, and cartilage. As well as medical applications, It finds wide-spread use in cosmetics, particularly skin creams. In...

Viscotek TDAmax,Viscotek SEC-MALS,Zetasizer Nano ZS,Zetasizer Nano ZSP
Date recorded:
June 25 2014

Keywords: Polymer solutions English Molecular size Molecular weight Dynamic Light Scattering Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Cosmetics Personal care Specialty and novel polymers Webinar - Recorded Eastern Time Zetasizer Nano ZS Zetasizer Nano ZSP Microrheology Viscotek TDAmax Viscotek SEC-MALS 

Polymer solution characterization part 3: Branching out! Intrinsically useful views on polymer structure Webinar - Recorded (English)

Most scientists can easily understand polymer molecular weight differences but often intrinsic viscosity, a harder concept to grasp, is a more useful measure of a polymer in solution. This webinar describes in simple terms what intrinsic ...

Viscotek TDAmax,Viscotek 270max,Viscotek RImax,Viscotek TDA 305,Viscotek SEC-MALS,Viscotek RImax
Date recorded:
June 24 2014

Keywords: Polymer solutions English Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Food additives Bulk (commodity) polymers Rubbers and elastomers Polymers from renewable sources Polysaccharides Webinar - Recorded Eastern Time Proteins Viscotek 270max Viscotek RImax Viscotek TDAmax Viscotek SEC-MALS Viscotek TDA 305 

Seal Wash Systems for GPCmax and VE-1122 Pumps – set up and operation Technical Note (English)

This technical note describes the two different ways of operating the seal wash system in the Viscotek GPCmax and VE-1122 pumps, which are essential for maximising the lifetime of seals and pistons.

Keywords: English Technical Note Gel Permeation Chromatography Size Exclusion Chromatography Viscotek 270max Viscotek RImax Viscotek TDAmax 
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