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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

Related products

OMNISEC The world’s most advanced multi-detector GPC/SEC system Image
Measurement
Molecular weight, Molecular size, Molecular structure
Temperature range
20°C to 65°C
Technology
Size Exclusion Chromatography, Static Light Scattering, Gel Permeation Chromatography
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Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Temperature range
25°C to 160°C
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
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Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Measurement
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.3nm to 2µm
Dispersion type
Wet
Technology
Size Exclusion Chromatography, Dynamic Light Scattering
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Analytical strategies for inkjet formulation – A customer perspective Webinar - Live (English)

Analytical systems from Malvern Instruments are now used routinely to advance inkjet formulation at Domino Printing Sciences plc in the UK, one of the world’s leading printing technology companies. Domino are best known for printing “sell-by” dates o...

Date:
February 12 2015
Language:
English

Keywords: English Rheology and viscosity Dynamic Light Scattering Gel Permeation Chromatography Paints, inks and coatings Webinar - Live Eastern Time 

GPC/SEC analysis of polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA) using OMNISEC Application Note (English)

In this application note, a selection of different PLA and PLGA polymer samples were analyzed on Malvern's OMNISEC GPC/SEC system, which combines multiple detectors to provide information about structure and solution properties.


Keywords: Polymer solutions English Application Note Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Polymers from renewable sources Specialty and novel polymers Polymer recycling OMNISEC 

Measurements of absolute molecular weight of synthetic polymers using OMNISEC Application Note (English)

In this application note, the molecular weight, molecular weight distribution and size of common polymers are measured using the OMNISEC system.


Keywords: Polymer solutions English Application Note Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Rubbers and elastomers Specialty and novel polymers Polymer recycling OMNISEC 

Structure-molecular weight relationships of synthetic polymers Application Note (English)

In this application note, the structural distribution of some common polymers are compared using the Mark-Houwink plot. The data are all generated using the advanced OMNISEC multi-detector GPC/SEC system


Keywords: English Application Note Viscotek range Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography OMNISEC 

An introduction to OMNISEC RESOLVE Technical Note (English)

This technical note describes the features and benefits of OMNISEC RESOLVE. It also includes a discussion of the value of OMNISEC as a complete system as opposed to upgrading an existing conventional system to advanced detection.


Keywords: Polymer solutions English Technical Note Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Bulk (commodity) polymers Engineering polymers Polymers from renewable sources Specialty and novel polymers Polymer recycling OMNISEC 
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Analytical strategies for inkjet formulation – A customer perspective
(February 12 2015)

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