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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.
When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.
By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.
For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:
From novel polymers to polymer formulations and additives, in applications from paints and coatings to foods and pharmaceuticals, Malvern offers a range of GPC systems or individual GPC detectors including SEC-MALS to suit your application needs.
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There is a strong global trend in automotive design that features a continuous increase in the use of conventional, performance, and novel polymeric materials. This is a result of weight savings, design flexibility, and ease of fabrication offered by...
Gel Permeation Chromatography (GPC) also known as Size Exclusion Chromatography (SEC), is a very popular analytical tool for polymer characterization. Low molecular weight polymers such as polyols, epoxies and polycaprolactones (amongst others) are u...
Two antibody samples were characterized using column calibration and multi-detection SEC, and the results compared to show how multi-detection SEC provides more accurate data and a more complete characterization of the protein mixtures under study.
Here, we will show how to separate the effects of a structural difference induced by a compositional change to a polymer (e.g. substitution) and the structural change induced by polymer chain branching, using OMNISEC.
A selection of different PLA and PLGA polymer samples were analyzed on Malvern's OMNISEC GPC/SEC system, which combines multiple detectors to provide information about structure and solution properties.
(Webinar - Recorded)
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