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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

Related products

OMNISEC The world’s most advanced multi-detector GPC/SEC system Image
Measurement
Molecular weight, Molecular size, Molecular structure
Molecular weight range
200Da to 10MDa
Minimum sample mass (polystyrene)
100ng
Minimum sample mass (BSA)
100ng
Technology
Size Exclusion Chromatography, Static Light Scattering, Gel Permeation Chromatography
More information
Viscotek SEC-MALS More angles, more data, more choice! Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation
Molecular weight range
1000Da to 10MDa
Minimum sample mass (polystyrene)
1µg
Minimum sample mass (BSA)
2µg
Technology
Gel Permeation Chromatography, Size Exclusion Chromatography, Static Light Scattering
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Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Molecular weight range
1000Da to 10MDa
Minimum sample mass (polystyrene)
1µg
Minimum sample mass (BSA)
1µg
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
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Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Measurement
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.3nm to 2µm
Dispersion type
Wet
Technology
Size Exclusion Chromatography, Dynamic Light Scattering
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How low can you go? New advances in the analysis of low molecular weight polymers by GPC/SEC Webinar - Live (English)

Gel Permeation Chromatography (GPC) also known as Size Exclusion Chromatography (SEC), is a very popular analytical tool for polymer characterization. Low molecular weight polymers such as polyols, epoxies and polycaprolactones (amongst others) are ...

Product:
OMNISEC
Date:
August 25 2015
Language:
English


Introducing the most advanced GPC/SEC system available: OMNISEC Technical Note (English)

Here we describe the features and benefits of the OMNISEC GPC/SEC system and explain how OMNISEC sets a new standard in molecular characterization.



Size Exclusion Chromatography / Gel Permeation Chromatography: An Introduction in 30 Minutes Whitepaper (English)

GPC/SEC is mainly used for the characterization of macromolecules including synthetic and natural polymers (including polysaccharides) as well as proteins or RNA/DNA. This white paper provides an introduction to the technique in 30 minutes.



Overcoming challenges in the detection and characterization of PLGA using the latest developments in GPC/SEC technology Poster (English)

PLA, PLGA and their copolymers are biocompatible, biodegradable and used in a number of medical applications. However, analysis of this low molecular weight and low dn/dc sample pushes the sensitivity boundaries of all previous light scattering detec...


Keywords: Polymer solutions English Poster Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography OMNISEC 

Using GPC/SEC for excipient characterization Article (English)

The properties of polymeric excipients can directly affect the clinical efficacy, safety, and quality of a finished pharmaceutical product and are routinely identified as critical quality attributes (CQAs). This article looks at how gel permeation/si...


Keywords: English Article Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Biological drug characterization and development Drug discovery Excipients and coatings OMNISEC 
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Upcoming webinar

How low can you go? New advances in the analysis of low molecular weight polymers by GPC/SEC
(August 25 2015)

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