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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

Related products

OMNISEC The world’s most advanced multi-detector GPC/SEC system Image
Measurement
Molecular weight, Molecular size, Molecular structure
Molecular weight range
200Da to 10MDa
Minimum sample mass (polystyrene)
100ng
Minimum sample mass (BSA)
100ng
Technology
Size Exclusion Chromatography, Static Light Scattering, Gel Permeation Chromatography
More information
Viscotek SEC-MALS More angles, more data, more choice! Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation
Molecular weight range
1000Da to 10MDa
Minimum sample mass (polystyrene)
1µg
Minimum sample mass (BSA)
2µg
Technology
Gel Permeation Chromatography, Size Exclusion Chromatography, Static Light Scattering
More information
Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Molecular weight range
1000Da to 10MDa
Minimum sample mass (polystyrene)
1µg
Minimum sample mass (BSA)
1µg
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
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Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Measurement
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.3nm to 2µm
Dispersion type
Wet
Technology
Size Exclusion Chromatography, Dynamic Light Scattering
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Structure-molecular weight relationships of synthetic polymers Application Note (English)

In this application note, the structural distribution of some common polymers are compared using the Mark-Houwink plot. The data are all generated using the advanced OMNISEC multi-detector GPC/SEC system


Keywords: English Application Note Viscotek range Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography OMNISEC 

Improve your understanding of the effect of polysaccharide molecular weight & structure on final product performance Webinar - Live (English)

From simple food additives to complex material used in high-tech eye surgery and targeted drug delivery systems, polysaccharides have earned unparalleled attention when it comes to macromolecular characterization. With more emphasis on product perfor...

Product:
OMNISEC
Date:
July 8 2015
Language:
English

Keywords: English Molecular structure Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Webinar - Live Eastern Time OMNISEC 


Ten reasons protein characterization scientists should upgrade from single to multi-detector SEC Whitepaper (English)

The top 10 reasons to consider an advanced multi-detector SEC system, which incorporates light scattering detectors for the measurement of absolute molecular weight and molecular weight distribution with excellent accuracy.


Keywords: English Whitepaper Viscotek range Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Membrane proteins Viruses and vaccines Protein aggregation Proteins Biopharmaceutical development OMNISEC 

Malvern polyacrylonitrile characterization package Webinar - Recorded (English)

Gel Permeation Chromatography (GPC) also known as Size Exclusion Chromatography (SEC), is a very popular analytical tool for characterizing natural and synthetic polymers. This seminar will show excellent results possible with our Triple Detection G...

Product:
OMNISEC
Date recorded:
June 24 2015
Language:
English

Keywords: English Gel Permeation Chromatography Size Exclusion Chromatography Webinar - Recorded Eastern Time OMNISEC 
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Upcoming webinar

Improve your understanding of the effect of polysaccharide molecular weight & structure on final product performance
(July 8 2015)

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