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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

Related products

Viscotek range The leading multi-detector GPC/SEC systems and detectors. Image
Measurement
Molecular structure, Molecular weight, Molecular size, Protein aggregation, Rheology and viscosity
Temperature range
25°C to 160°C
Technology
Dilute Solution Viscometry, Size Exclusion Chromatography, Gel Permeation Chromatography, Static Light Scattering
More information
Zetasizer µV Modular size and molecular weight detector that can be added to any SEC system. Image
Measurement
Molecular size
Temperature range
2°C to 90°C
Particle size range
0.3nm to 2µm
Dispersion type
Wet
Technology
Size Exclusion Chromatography, Dynamic Light Scattering
More information
 
 

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Analytical strategies for inkjet formulation – A customer perspective Webinar - Live (English)

Analytical systems from Malvern Instruments are now used routinely to advance inkjet formulation at Domino Printing Sciences plc in the UK, one of the world’s leading printing technology companies. Domino are best known for printing “sell-by” dates o...

Date:
February 12 2015
Language:
English

Keywords: English Rheology and viscosity Dynamic Light Scattering Gel Permeation Chromatography Paints, inks and coatings Webinar - Live Eastern Time 

OMNISEC live launch (9am UK) Webinar - Live (English)

Join our live launch event January 27 where we introduce the world’s most advanced SEC system - OMNISEC. Find out how OMNISEC will help you… Synthetic Polymers Monitor improvement in product performance when changing polymer components Investig...

Product:
Viscotek range
Date:
January 27 2015
Language:
English

Keywords: English Viscotek range Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Polymers, plastics and rubbers Webinar - Live Greenwich Time Biopharmaceutical development 

OMNISEC live launch (10:30 US EST) Webinar - Live (English)

Join our live launch event January 27 where we introduce the world’s most advanced SEC system - OMNISEC. Find out how OMNISEC will help you… Synthetic Polymers Monitor improvement in product performance when changing polymer components Investig...

Product:
Viscotek range
Date:
January 27 2015
Language:
English

Keywords: English Viscotek range Molecular weight Gel Permeation Chromatography Size Exclusion Chromatography Polymers, plastics and rubbers Webinar - Live Eastern Time Biopharmaceutical development 

GPC Characterization of Nylon using Formic Acid for Reduced Cost per Analysis Application Note (English)

GPC/SEC can be used to characterize commodity or bulk manufactured polymers. Here we describe how the use of formic acid instead of HFIP as the dissolution solvent and/or mobile phase can lead to improvements in both cost per analysis and health and ...


Keywords: Polymer solutions English Method development Application Note Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Bulk (commodity) polymers Viscotek 270max Viscotek TDAmax Viscotek TDA 305 

Exploring the role of SEC-MALS in protein and polymer characterization Webinar - Recorded (English)

Size exclusion chromatography (SEC) is a chromatographic technique for the characterization of proteins and biopharmaceuticals, as well as natural and synthetic polymers. Traditional systems comprised a single concentration detector (Conventional Cal...

Product:
Viscotek SEC-MALS,Viscotek 270max,Viscotek TDAmax,Viscotek RImax
Date recorded:
October 17 2014
Language:
English

Keywords: Polymer solutions English Molecular structure Molecular size Molecular weight Gel Permeation Chromatography Static Light Scattering Size Exclusion Chromatography Food additives Rubbers and elastomers Specialty and novel polymers Membrane proteins Polysaccharides Webinar - Recorded GMT Time Protein aggregation Proteins Bioformulation development Antibodies and derivatives Viscotek 270max Viscotek RImax Viscotek TDAmax Viscotek SEC-MALS 
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