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Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.
When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.
By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.
For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:
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In this application note, the structural distribution of some common polymers are compared using the Mark-Houwink plot. The data are all generated using the advanced OMNISEC multi-detector GPC/SEC system
From simple food additives to complex material used in high-tech eye surgery and targeted drug delivery systems, polysaccharides have earned unparalleled attention when it comes to macromolecular characterization. With more emphasis on product perfor...
The stability of a protein sample and its tendency to aggregate is explored using a combination of SEC-MALS and DLS
The top 10 reasons to consider an advanced multi-detector SEC system, which incorporates light scattering detectors for the measurement of absolute molecular weight and molecular weight distribution with excellent accuracy.
Gel Permeation Chromatography (GPC) also known as Size Exclusion Chromatography (SEC), is a very popular analytical tool for characterizing natural and synthetic polymers. This seminar will show excellent results possible with our Triple Detection G...
(Webinar - Recorded)
Improve your understanding of the effect of polysaccharide molecular weight & structure on final product performance
(July 8 2015)
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