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Automated imaging is a high resolution direct technique for characterizing particles. Individual particle images are captured from dispersed samples and analyzed to determine their particle size, particle shape and other physical properties. Statistically representative distributions can be constructed by measuring 10’s to 100’s of thousands of particles per measurement.

Static imaging systems require a stationary dispersed sample, whereas in dynamic imaging systems the sample flows past the image capture optics. The technique is often used in conjunction with ensemble based particle sizing methods such as laser diffraction to gain a deeper understanding of the sample or to validate the ensemble based measurements. Typical applications include:

  • Measurement of shape differences where particle size alone does not give differentiation.
  • Detection and/or enumeration of agglomerates, oversized particles or contaminant particles.
  • Size measurement of non-spherical particles such as needle shaped crystals.
  • Validation of ensemble based particle size measurements such as laser diffraction.

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Masterclass 1: Principios basicos de caracterizacion de particlulas usando un sistema automatizado para su analisis Webinar - Live (Spanish)

En este webinar, el primero de una serie, se presentaran los conceptos básicos de análisis de imágenes. Se cubriran los parámetros de medicion y cómo dicha información puede ser relacionada a problemas reales. La forma de una partícula puede afectar ...

Morphologi G3
October 29 2014

Keywords: Morphologi G3 Particle shape Particle size Image analysis Webinar - Live Mexico Time Pharmaceutical development Drug discovery Pharmaceutical chemical development Pharmaceutical formulation and development Pharmaceutical manufacturing Spanish 

Applying image analysis to support the development of particle sizing methods Application Note (English)

Getting a sample to a stable and reproducible state of dispersion is an important part of method development when carrying out particle size analysis. In this application note we show how the Mastersizer’s Hydro Sight accessory can be used to visuali...

Keywords: QA/QC and routine testing Root cause analysis (troubleshooting) Suspensions, slurries and pastes English Method development Application Note Mastersizer range Particle shape Particle size Image analysis Laser diffraction 

Beyond Particle Size Article (English)

The use of ‘green’ cement additives like fly ash or limestone adds complexities to modern cement production. Defining the performance of these cements requires information about the component-specific particle size of the different compon...

Keywords: English Article Chemical identification Particle shape Particle size Image analysis Raman spectroscopy Cement Morphologi range 

21 CFR Part 11 user guide for the Morphologi G3 software Technical Note (English)

This document provides details on the features provided for Morphologi instruments to aid technical compliance to 21 CFR Part 11.

Keywords: English Technical Note Morphologi G3 Particle shape Particle size Image analysis 

21 CFR Part 11 compliance guide for the Morphologi software Technical Note (English)

This note details the requirements of 21 CFR Part 11and describes how the Morphologi software meets these requirements.

Keywords: English Technical Note Morphologi G3 Particle shape Particle size Image analysis Biopharmaceutical development Pharmaceutical development 
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