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Automated imaging is a high resolution direct technique for characterizing particles. Individual particle images are captured from dispersed samples and analyzed to determine their particle size, particle shape and other physical properties. Statistically representative distributions can be constructed by measuring 10’s to 100’s of thousands of particles per measurement.

Static imaging systems require a stationary dispersed sample, whereas in dynamic imaging systems the sample flows past the image capture optics. The technique is often used in conjunction with ensemble based particle sizing methods such as laser diffraction to gain a deeper understanding of the sample or to validate the ensemble based measurements. Typical applications include:

  • Measurement of shape differences where particle size alone does not give differentiation.
  • Detection and/or enumeration of agglomerates, oversized particles or contaminant particles.
  • Size measurement of non-spherical particles such as needle shaped crystals.
  • Validation of ensemble based particle size measurements such as laser diffraction.

Related products

Morphologi range Advanced particle characterization. Image
Measurement
Particle shape, Particle size, Chemical identification
Particle size range
0.5µm to 1000µm
Technology
Image analysis, Raman spectroscopy
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Sysmex FPIA-3000 Rapid particle size and shape analysis of suspensions Image
Measurement
Particle size, Particle shape
Particle size range
0.8µm to 300µm
Dispersion type
Wet
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Image analysis
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21 CFR Part 11 user guide for the Morphologi G3 software Technical Note (English)

This document provides details on the features provided for Morphologi instruments to aid technical compliance to 21 CFR Part 11.


Keywords: English Technical Note Morphologi G3 Particle shape Particle size Image analysis 

21 CFR Part 11 compliance guide for the Morphologi software Technical Note (English)

This note details the requirements of 21 CFR Part 11and describes how the Morphologi software meets these requirements.


Keywords: English Technical Note Morphologi G3 Particle shape Particle size Image analysis Biopharmaceutical development Pharmaceutical development 

Imaging Masterclass 2: Sample preparation techniques for particle size and shape measurements Webinar - Recorded (English)

For successful sample characterisation by image analysis, as with any other analytical technique, good sample preparation is critical. In this webinar we will discuss best practise in method development and describe a number of dispersion methods for...

Product:
Morphologi G3,Sysmex FPIA-3000
Date recorded:
March 25 2014
Language:
English

Keywords: English Morphologi G3 Sysmex FPIA-3000 Particle shape Particle size Image analysis Webinar - Recorded Eastern Time 

Setting pharmaceutical product specifications for particle size analysis Webinar - Recorded (English)

The end point of any particle size measurement is to provide improved product or process understanding and/or control. It order to achieve this, it is important that the size specifications selected are relevant to those products or processes. In thi...

Product:
Mastersizer range,Morphologi G3
Date recorded:
March 19 2014
Language:
English

Keywords: English Mastersizer range Morphologi G3 Particle shape Particle size Image analysis Laser diffraction Webinar - Recorded Eastern Time Pharmaceutical development 

Component Characterization of Cements using Morphologi G3-ID Application Note (English)

Using the Morphologi G3-ID, the particle size and shape distributions for individual cement componets can be measured within cement blends, aiding understanding of how different cement types perform during development and production.


Keywords: Powders and granules English Application Note Chemical identification Particle shape Particle size Image analysis Raman spectroscopy Cement Morphologi G3-ID 
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