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Automated imaging is a high resolution direct technique for characterizing particles. Individual particle images are captured from dispersed samples and analyzed to determine their particle size, particle shape and other physical properties. Statistically representative distributions can be constructed by measuring 10’s to 100’s of thousands of particles per measurement.

Static imaging systems require a stationary dispersed sample, whereas in dynamic imaging systems the sample flows past the image capture optics. The technique is often used in conjunction with ensemble based particle sizing methods such as laser diffraction to gain a deeper understanding of the sample or to validate the ensemble based measurements. Typical applications include:

  • Measurement of shape differences where particle size alone does not give differentiation.
  • Detection and/or enumeration of agglomerates, oversized particles or contaminant particles.
  • Size measurement of non-spherical particles such as needle shaped crystals.
  • Validation of ensemble based particle size measurements such as laser diffraction.

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Particle Sizing Masterclass 3: method development Webinar - Live (English)

In this third webinar in the particle sizing masterclass we will look at method development and we will concentrate on the techniques of laser diffraction and automated image analysis. The most important thing in method development is always to make ...

Date:
April 28 2015
Language:
English

Keywords: English Particle size Laser diffraction Webinar - Live Eastern Time 

Particle Size Masterclass 2: which technique is best for me? Webinar - Recorded (English)

In the second webinar in the particle size masterclass series, we follow on from why you need to measure particle size, covered in the first masterclass, by looking at how to measure particle size. We started with considerations for choosing a partic...

Date recorded:
March 19 2015
Language:
English

Keywords: English Particle size Dynamic Light Scattering Image analysis Laser diffraction Webinar - Recorded Eastern Time Nanoparticle Tracking Analysis 

Detecting agglomerates within pharmaceutical formulations Article (English)

Particle agglomeration can compromise the clinical efficacy of pharmaceutical products and must therefore be closely controlled. Automated particle image analysis provides one technology which can aid agglomerate detection. This article provides prac...


Keywords: QA/QC and routine testing Development English Article Particle shape Particle size Image analysis Pharmaceutical formulation and development Pharmaceutical manufacturing Morphologi range 

Accelerating the Development of Generic Pharmaceuticals: Developing an Analytical Toolkit Suitable for De-formulating Complex Reference Products Article (English)

In its report ‘Critical Path Opportunities for Generic Drugs’, the FDA emphasizes the need for advances in the field of analytical sciences in order to accelerate the development of generic products. Here, Paul Kippax highlights techniques that are e...


Keywords: Development English Article Chemical identification Particle shape Particle size Gel Permeation Chromatography Image analysis Raman spectroscopy Size Exclusion Chromatography Pharmaceutical formulation and development Morphologi G3-ID 

Forensic analysis of an artificial sweetener commonly employed in hoax powder attacks using Morphologically Directed Raman spectroscopy Application Note (English)

This application note details how Morphologically Directed Raman Spectroscopy (MDRS) using the Morphologi G3-ID can be applied to the forensic identification of commercially sourced white powders commonly used in hoax bio-terrorism powder attacks. It...


Keywords: Root cause analysis (troubleshooting) Powders and granules English Application Note Chemical identification Particle shape Particle size Image analysis Raman spectroscopy Morphologi G3-ID 
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