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Automated imaging is a high resolution direct technique for characterizing particles. Individual particle images are captured from dispersed samples and analyzed to determine their particle size, particle shape and other physical properties. Statistically representative distributions can be constructed by measuring 10’s to 100’s of thousands of particles per measurement.

Static imaging systems require a stationary dispersed sample, whereas in dynamic imaging systems the sample flows past the image capture optics. The technique is often used in conjunction with ensemble based particle sizing methods such as laser diffraction to gain a deeper understanding of the sample or to validate the ensemble based measurements. Typical applications include:

  • Measurement of shape differences where particle size alone does not give differentiation.
  • Detection and/or enumeration of agglomerates, oversized particles or contaminant particles.
  • Size measurement of non-spherical particles such as needle shaped crystals.
  • Validation of ensemble based particle size measurements such as laser diffraction.

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Morphologi range Advanced particle characterization. Image
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0.5µm to 1000µm
Technology
Image analysis, Raman spectroscopy
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Sysmex FPIA-3000 Rapid particle size and shape analysis of suspensions Image
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Characterization of protein aggregates in suspension and on a filter membrane by Morphologically-Directed Raman Spectroscopy Application Note (English)

The combination of static microscopy and Raman spectroscopy in the Morphologi G3-ID enables automated chemical identification of protein aggregates and other contaminants in a biotherapeutic sample, either in suspension via a thin-path wet cell or on...



Discriminating between polymorphs of acetaminophen using Morphologically-Directed Raman Spectroscopy (MDRS) Application Note (English)

Polymorphic conversions are an ongoing problem in the pharmaceutical industry.  Here we describe the use of Morphologically-Directed Raman Spectroscopy to distinguish and quantify particles of different polymorphic types of acetaminophen (paracetamol...



Particle Sizing Masterclass 3: method development Webinar - Recorded (English)

In this third webinar in the particle sizing masterclass we look at method development and we concentrate on the techniques of laser diffraction and automated image analysis. The most important thing in method development is always to make sure that ...

Product:
Mastersizer range,Spraytec
Date recorded:
April 28 2015
Language:
English

Keywords: English Mastersizer range Spraytec Particle size Image analysis Laser diffraction Webinar - Recorded Eastern Time 

Particle Size Masterclass 2: which technique is best for me? Webinar - Recorded (English)

In the second webinar in the particle size masterclass series, we follow on from why you need to measure particle size, covered in the first masterclass, by looking at how to measure particle size. We started with considerations for choosing a partic...

Date recorded:
March 19 2015
Language:
English

Keywords: English Particle size Dynamic Light Scattering Image analysis Laser diffraction Webinar - Recorded Eastern Time Nanoparticle Tracking Analysis 

Detecting agglomerates within pharmaceutical formulations Article (English)

Particle agglomeration can compromise the clinical efficacy of pharmaceutical products and must therefore be closely controlled. Automated particle image analysis provides one technology which can aid agglomerate detection. This article provides prac...


Keywords: QA/QC and routine testing Development English Article Particle shape Particle size Image analysis Pharmaceutical formulation and development Pharmaceutical manufacturing Morphologi range 
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