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Automated imaging is a high resolution direct technique for characterizing particles. Individual particle images are captured from dispersed samples and analyzed to determine their particle size, particle shape and other physical properties. Statistically representative distributions can be constructed by measuring 10’s to 100’s of thousands of particles per measurement.

Static imaging systems require a stationary dispersed sample, whereas in dynamic imaging systems the sample flows past the image capture optics. The technique is often used in conjunction with ensemble based particle sizing methods such as laser diffraction to gain a deeper understanding of the sample or to validate the ensemble based measurements. Typical applications include:

  • Measurement of shape differences where particle size alone does not give differentiation.
  • Detection and/or enumeration of agglomerates, oversized particles or contaminant particles.
  • Size measurement of non-spherical particles such as needle shaped crystals.
  • Validation of ensemble based particle size measurements such as laser diffraction.

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Particle Size Masterclass 2: which technique is best for me? Webinar - Live (English)

In the second webinar in the particle size masterclass series, we will follow on from why you need to measure particle size, covered in the first masterclass, by looking at how to measure particle size. We’ll start with considerations for choosing a ...

Date:
March 19 2015
Language:
English

Keywords: English Particle size Dynamic Light Scattering Image analysis Laser diffraction Webinar - Live Eastern Time Nanoparticle Tracking Analysis 

Detective work Article (English)

Particle agglomeration can compromise the clinical efficacy of pharmaceutical products and must therefore be closely controlled. This article provides practical guidance on using automated imaging for efficient agglomerate detection.


Keywords: QA/QC and routine testing Development Aerosols and sprays Powders and granules Suspensions, slurries and pastes English Article Chemical identification Particle shape Particle size Image analysis Raman spectroscopy Pharmaceutical formulation and development Pharmaceutical manufacturing Excipients and coatings Morphologi range 

Accelerating the Development of Generic Pharmaceuticals: Developing an Analytical Toolkit Suitable for De-formulating Complex Reference Products Article (English)

In its report ‘Critical Path Opportunities for Generic Drugs’, the FDA emphasizes the need for advances in the field of analytical sciences in order to accelerate the development of generic products. Here, Paul Kippax highlights techniques that are e...


Keywords: Development English Article Chemical identification Molecular weight Particle shape Particle size Gel Permeation Chromatography Image analysis Raman spectroscopy Size Exclusion Chromatography Pharmaceutical formulation and development 

Forensic analysis of an artificial sweetener commonly employed in hoax powder attacks using Morphologically Directed Raman spectroscopy Application Note (English)

This application note details how Morphologically Directed Raman Spectroscopy (MDRS) using the Morphologi G3-ID can be applied to the forensic identification of commercially sourced white powders commonly used in hoax bio-terrorism powder attacks. It...


Keywords: Root cause analysis (troubleshooting) Powders and granules English Application Note Chemical identification Particle shape Particle size Image analysis Raman spectroscopy Morphologi G3-ID 

Characterization of pollen samples with the Morphologi® G3SE Application Note (English)

Analysis of pollen samples on the Morphologi G3 allows them to be automatically characterized in terms of both particle size and shape, aiding the distinction of different pollen types during the development and testing of immunotherapy or diagnostic...


Keywords: QA/QC and routine testing Contaminants and foreign particles English Application Note Morphologi G3 Particle shape Particle size Image analysis Pharmaceutical formulation and development 
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