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Nanoparticle Tracking Analysis (NTA) utilizes the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension.
A laser beam is passed through the sample chamber, the particles in suspension in the path of the beam scatter light in such a manner that they can be easily visualized via a long working distance, x20 magnification microscope onto which is mounted a video camera. The camera captures a video file of the particles moving under Brownian motion. The software tracks many particles individually and using the Stokes Einstein equation calculates their hydrodynamic diameters. The NanoSight range of instruments provides high resolution particle size, concentration and aggregation measurements while a fluorescence mode provides specific results for labelled particles. The range provides real time monitoring of the subtle changes in the characteristics of particle populations with all of these analyses uniquely confirmed by visual validation.
The technique enables the simultaneous measurement of multiple characteristics saving on time and sample volumes while minimal sample preparation and instrument consumables reduces running costs on a day to day basis.
ASTM E2834-12(2012) Standard Guide for Measurement of Particle Size Distribution of Nanomaterials in Suspension by Nanoparticle Tracking Analysis (NTA). Applications include:
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Ultra-Fine (nano) bubbles have garnered increasing interest over the last few years as they open up the potential for improvements in a variety of applications from cleaning to agriculture. However they are still somewhat a mystery with respect to th...
This webinar will introduce NTA 3.0, Malvern's latest software suite for the NanoSight range, which is available as a free upgrade to any previous NTA software.
NTA 3.0 introduces a new work-flow, interface and significantly improved sizing algorith...
This white paper highlights the growth in the use of the technique of Nanoparticle Tracking Analysis (NTA) as applied to nanoparticles and nanomaterials production and analysis, from the very first reports on nanoscale silver and gold (Lundahl et al....
As Nanoparticle Tracking Analysis (NTA) allows suspensions of nanoparticles to be visualized, sized and enumerated based on a particle-by-particle basis, its ability to determine the concentration and direct number frequency based particle size distr...
The study of exosomes and other cell-derived microvesicles is an area of rapidly growing importance and the subject of intense interest and research. The previous lack of suitable methods for their detection, analysis, enumeration and phenotyping is ...
(Webinar - Recorded)
Introducing NTA 3.0 software for NanoSight users
(November 5 2014)
(Webinar - Live)
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