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Nanoparticle Tracking Analysis (NTA) utilizes the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension.
A laser beam is passed through the sample chamber and the particles in suspension in the path of the beam scatter light in such a manner that they can be easily visualized via a long working distance, x20 magnification microscope onto which is mounted a video camera. The camera captures a video file of the particles moving under Brownian motion. The Nanoparticle Tracking Analysis (NTA) software tracks many particles individually and using the Stokes Einstein equation calculates their hydrodynamic diameters. The NanoSight range of instruments provides high resolution particle size, concentration and aggregation measurements while a fluorescence mode provides specific results for labelled particles. The range provides real time monitoring of the subtle changes in the characteristics of particle populations with all of these analyses confirmed by visual validation.
The technique enables the simultaneous measurement of multiple characteristics saving on time and sample volumes while minimal sample preparation and instrument consumables reduces running costs on a day to day basis.
ASTM E2834-12(2012) Standard Guide for Measurement of Particle Size Distribution of Nanomaterials in Suspension by Nanoparticle Tracking Analysis (NTA). Applications include:
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The need to characterize different properties of nanomaterials continues to grow rapidly. Since the commercialization of the technique in 2004, Nanoparticle tracking Analysis (NTA) has become increasingly prevalent in a wide variety of different rese...
NanoSight instruments with upgraded concentration measurement have increased concentration measurement accuracy and repeatability. This provides improved measurement robustness and removes the influence of user settings. Data is shown here that illus...
With ever-increasing amounts of nanomaterials being commercially produced and utilized, there exists a need to determine the lifecycle and fate of these materials, with an understandable focus on potentially toxic effects. This poster describes ...
This poster outlines an example where the methodology of Nanoparticle Tracking Analysis (NTA) is used to characterize nanoparticles for drug delivery purposes
NTA was successfully used to characterize a broad range of polymer particles and polymer suspensions for various applications including thermo responsive polymers, mix size polymer microspheres as well as drug delivery vesicles.
(Webinar - Recorded)
NTA is a relatively new addition to the lab but is already bringing value to several areas of research. For example, the ability to visualize particles over time is allowing one research group developing self-assembling proteins to trace the changes in size of their molecules over time to better understand the dynamics of aggregation.
Dr Krystelle Mafina,
Queen Mary University,
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