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Nanoparticle Tracking Analysis (NTA) utilizes the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension.


A laser beam is passed through the sample chamber, the particles in suspension in the path of the beam scatter light in such a manner that they can be easily visualized via a long working distance, x20 magnification microscope onto which is mounted a video camera. The camera captures a video file of the particles moving under Brownian motion. The software tracks many particles individually and using the Stokes Einstein equation calculates their hydrodynamic diameters. The NanoSight range of instruments provides high resolution particle size, concentration and aggregation measurements while a fluorescence mode provides specific results for labelled particles. The range provides real time monitoring of the subtle changes in the characteristics of particle populations with all of these analyses uniquely confirmed by visual validation.

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The technique enables the simultaneous measurement of multiple characteristics saving on time and sample volumes while minimal sample preparation and instrument consumables reduces running costs on a day to day basis.

ASTM E2834-12(2012) Standard Guide for Measurement of Particle Size Distribution of Nanomaterials in Suspension by Nanoparticle Tracking Analysis (NTA). Applications include:

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NanoSight range Visualize and measure nanoparticle size and concentration Image
Measurement
Particle size, Particle concentration, Protein aggregation
Particle size range
10nm to 2000nm
Technology
Nanoparticle Tracking Analysis
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Nanobubbles - separating the fact from fiction Webinar - Live (English)

Ultra-Fine (nano) bubbles have garnered increasing interest over the last few years as they open up the potential for improvements in a variety of applications from cleaning to agriculture. However they are still somewhat a mystery with respect to th...

Product:
Archimedes,NanoSight LM10,NanoSight NS300,NanoSight NS500,Zetasizer Nano ZSP
Date:
October 30 2014
Language:
English

Keywords: Nanoparticles English Particle concentration Particle size Dynamic Light Scattering Abrasives Cement Ceramics Metals Minerals Mining waste Coal and fly ash Carbon Webinar - Live Eastern Time Resonant mass measurement Zetasizer Nano ZSP Archimedes NanoSight NS500 NanoSight NS300 NanoSight LM10 Nanobubbles Nanoparticle Tracking Analysis 

How can Nanoparticle Tracking Analysis assist in the production of nanoparticles Whitepaper (English)

This white paper highlights the growth in the use of the technique of Nanoparticle Tracking Analysis (NTA) as applied to nanoparticles and nanomaterials production and analysis, from the very first reports on nanoscale silver and gold (Lundahl et al....


Keywords: Nanoparticles English Whitepaper Particle concentration Particle size NanoSight range Nano regulations Carbon nanotubes Nanoparticle Tracking Analysis 

Viruses and Viral Vaccines: Characterization by Nanoparticle Tracking Analysis Whitepaper (English)

As Nanoparticle Tracking Analysis (NTA) allows suspensions of nanoparticles to be visualized, sized and enumerated based on a particle-by-particle basis, its ability to determine the concentration and direct number frequency based particle size distr...


Keywords: English Whitepaper Particle concentration Particle size Viruses and vaccines NanoSight range Nanoparticle Tracking Analysis 

Exosomes and Microvesicles: Characterization by Nanoparticle Tracking Analysis Whitepaper (English)

The study of exosomes and other cell-derived microvesicles is an area of rapidly growing importance and the subject of intense interest and research. The previous lack of suitable methods for their detection, analysis, enumeration and phenotyping is ...


Keywords: English Whitepaper Particle concentration Particle size NanoSight range Extracellular vesicles Nanoparticle Tracking Analysis 

Assessing Drug Encapsulation Efficiency using Nanoparticle Tracking Analysis Application Note (English)

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how ...


Keywords: Nanoparticles English Application Note Particle concentration Particle size Liposomes and micelles Viruses and vaccines Biological drug characterization and development Biopharmaceutical manufacturing NanoSight range Nanoparticle Tracking Analysis 
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Nanobubbles - separating the fact from fiction
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