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Nanoparticle Tracking Analysis (NTA) utilizes the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension.

A laser beam is passed through the sample chamber and the particles in suspension in the path of the beam scatter light in such a manner that they can be easily visualized via a long working distance, x20 magnification microscope onto which is mounted a video camera. The camera captures a video file of the particles moving under Brownian motion. The Nanoparticle Tracking Analysis (NTA) software tracks many particles individually and using the Stokes Einstein equation calculates their hydrodynamic diameters. The NanoSight range of instruments provides high resolution particle size, concentration and aggregation measurements while a fluorescence mode provides specific results for labelled particles. The range provides real time monitoring of the subtle changes in the characteristics of particle populations with all of these analyses confirmed by visual validation.

Measurement of Nanoparticles using Nanoparticle Tracking Analysis

The technique enables the simultaneous measurement of multiple characteristics saving on time and sample volumes while minimal sample preparation and instrument consumables reduces running costs on a day to day basis.

ASTM E2834-12(2012) Standard Guide for Measurement of Particle Size Distribution of Nanomaterials in Suspension by Nanoparticle Tracking Analysis (NTA). Applications include:

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A guide to technologies used for the analysis of particulates in injectable drugs Webinar - Live (English)

In recent years, the delivery of biological drugs via prefilled syringe-style devices has rapidly become more prevalent, in direct response to consumer demand. However, there are some challenges associated with this delivery method. One such challeng...

Archimedes,Morphologi G3-ID,NanoSight range,Zetasizer Nano range
November 29 2016

NanoSight NS300: Demo at your desk Webinar - Recorded (English)

This demo at your desk webinar will provide a real-time overview of the operation of the NanoSight NS300 for nanoparticle size and concentration measurements using Nanoparticle Tracking Analysis (NTA). You will see the instrument and software perform...

NanoSight NS300
Date recorded:
October 11 2016

Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products Webinar - Recorded (English)

Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...

Archimedes,Zetasizer range,Viscotek SEC-MALS,Morphologi G3-ID,NanoSight range
Date recorded:
September 20 2016

NanoSight NS500 Zeta Potential Analysis Technical Note (English)

NanoSight NS500 Zeta Potential Analysis Flow Chart for Use with NTA Software Versions 3.1 and 3.2

Enhancing NTA accuracy and repeatability with flow mode measurements Technical Note (English)

The standard measurement mode for Malvern’s NanoSight Nanoparticle Tracking Analysis (NTA) technique takes place with the sample static. In that case, the only motion in the analysis is the Brownian motion of the particles. Since NTA is a single-part...

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A guide to technologies used for the analysis of particulates in injectable drugs
(November 29 2016)

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