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Nanoparticle Tracking Analysis (NTA) utilizes the properties of both light scattering and Brownian motion in order to obtain the particle size distribution of samples in liquid suspension.
A laser beam is passed through the sample chamber, the particles in suspension in the path of the beam scatter light in such a manner that they can be easily visualized via a long working distance, x20 magnification microscope onto which is mounted a video camera. The camera captures a video file of the particles moving under Brownian motion. The software tracks many particles individually and using the Stokes Einstein equation calculates their hydrodynamic diameters. The NanoSight range of instruments provides high resolution particle size, concentration and aggregation measurements while a fluorescence mode provides specific results for labelled particles. The range provides real time monitoring of the subtle changes in the characteristics of particle populations with all of these analyses uniquely confirmed by visual validation.
The technique enables the simultaneous measurement of multiple characteristics saving on time and sample volumes while minimal sample preparation and instrument consumables reduces running costs on a day to day basis.
ASTM E2834-12(2012) Standard Guide for Measurement of Particle Size Distribution of Nanomaterials in Suspension by Nanoparticle Tracking Analysis (NTA). Applications include:
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This white paper addresses some of the latest work reported in the literature in which Nanoparticle Tracking Analysis (NTA) has been proposed, used and assessed in the study of nanoparticle-based drug delivery and targeting
Nanoparticle Tracking Analysis (NTA) has found use in a variety of investigations researching the toxicity and environmental impact of nanoparticles. Here we discuss various publications in which NTA has been used to measure particle size and concent...
The increasing number of nanomaterial based consumer products raises concerns about their possible impact on the environment. Suitable methods for their analysis are a particular problem in this regard. This white paper reviews the use of Nanoparticl...
Nanocarbon production and research has increased in recent years for both graphite and diamond forms. Here, we discuss examples where Nanoparticle Tracking Analysis is helping to understand and characterizae these carbon-based nanostructures.
Nanoparticle Tracking Analysis (NTA) can be used to study the stability of exosomes, and determine appropriate storage conditions under which aggregates are less likely to form. Here, an LM10 is used to measure the size and concentration of exosomes ...
(Webinar - Recorded)
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