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Raman spectroscopy is an established spectroscopic technique for measuring the chemical identity and structure of materials across many industries, including pharmaceuticals, fine chemicals, minerals and foods.

Raman spectroscopy has a very high chemical specificity and is routinely used to differentiate between different polymorphs of the same compound for example. When used in conjunction with static image analysis it provides a powerful means of measuring the chemical identity of individually dispersed particles within a sample.

Applications of this technique include:

  • Chemically specific particle characterization of ingredients in mixtures
  • Identification of contaminants or outlier particles
  • Quantification of chemical composition in mixtures by particle count.

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Morphologi G3-ID Automated measurement of particle size, shape and chemical identity. Image
Particle shape, Particle size, Chemical identification
Particle size range
1µm to 1000µm
Image analysis, Raman spectroscopy
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Zetasizer Helix Characterize secondary and tertiary structure to develop mechanistic insight into oligomerization and aggregation. Image
Protein aggregation, Zeta potential, Protein mobility, Molecular size, Molecular weight
Spectral performance
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Colloidal Stability & Conformational Changes in β-Lactoglobulin: Unfolding Unfolding to Self-Assembly Article (English)

A detailed understanding of the mechanism of unfolding, aggregation, and associated rheological changes is developed in this study for β-Lactoglobulin at different pH values through concomitant measurements utilizing dynamic light scattering (DLS), o...

Improved approaches for particulate characterization in biotherapeutics Webinar - Recorded (English)

Product quality and safety concerns have driven the enumeration of particulate species in injectable products. Guidelines, such as USP<787>, <788>, and <790>, describe methods for collecting accurate particle count and size data in...

Morphologi range
Date recorded:
July 30 2015

Exploring the effect of carbon microstructure on lithium-ion battery performance Application Note (English)

This application note describes the combined use of static optical microscopy and Raman spectroscopy in the Morphologi G3-ID to assess the various morphological classes of carbon for use in lithium-ion battery manufacture.  High levels of crystallini...

Characterization of protein aggregates in suspension and on a filter membrane by Morphologically-Directed Raman Spectroscopy Application Note (English)

The combination of static microscopy and Raman spectroscopy in the Morphologi G3-ID enables automated chemical identification of protein aggregates and other contaminants in a biotherapeutic sample, either in suspension via a thin-path wet cell or on...

Combined DLS/Raman provides New Molecular Insights of Complex Fluids Article (English)

In particular, this article demonstrates the correlation between molecular changes (Raman Spectroscopy) and microstructural evolution of rheological properties (DLS, DLS-optical microrheology) for the first time for surfactant-based wormlike micellar...

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Particles unmasked: “What is it, and where did it come from?”
(October 20 2015)

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