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Raman spectroscopy is an established spectroscopic technique for measuring the chemical identity and structure of materials across many industries, including pharmaceuticals, fine chemicals, minerals and foods.
Raman spectroscopy has a very high chemical specificity and is routinely used to differentiate between different polymorphs of the same compound for example. When used in conjunction with static image analysis it provides a powerful means of measuring the chemical identity of individually dispersed particles within a sample.
Applications of this technique include:
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A detailed understanding of the mechanism of unfolding, aggregation, and associated rheological changes is developed in this study for β-Lactoglobulin at different pH values through concomitant measurements utilizing dynamic light scattering (DLS), o...
Product quality and safety concerns have driven the enumeration of particulate species in injectable products. Guidelines, such as USP<787>, <788>, and <790>, describe methods for collecting accurate particle count and size data in...
This application note describes the combined use of static optical microscopy and Raman spectroscopy in the Morphologi G3-ID to assess the various morphological classes of carbon for use in lithium-ion battery manufacture. High levels of crystallini...
The combination of static microscopy and Raman spectroscopy in the Morphologi G3-ID enables automated chemical identification of protein aggregates and other contaminants in a biotherapeutic sample, either in suspension via a thin-path wet cell or on...
In particular, this article demonstrates the correlation between molecular changes (Raman Spectroscopy) and microstructural evolution of rheological properties (DLS, DLS-optical microrheology) for the first time for surfactant-based wormlike micellar...
(Webinar - Recorded)
Particles unmasked: “What is it, and where did it come from?”
(October 20 2015)
The Zetasizer Nano is so easy to use. All my students can familiarise themselves with it very quickly. As a result, we are purchasing a second instrument to ensure we have enough capacity for our expanding research programme in this area.
Department of Chemistry, at The University of Sheffield
We very much value the customer service and training opportunities from Malvern. In particular, the rapid diagnosis of any issues through direct internet connection with the Malvern customer service team has prevented us from suffering production downtime.
Dr. Cordula Grüttner
micromod Partikeltechnologie GmbH
The Malvern systems have proved highly effective, allowing us to further demonstrate the stability and purity of our products and how this may be translated into improving liquid biopharmaceutical formulations.
We’ve always been really happy with Malvern and while we’ve tried other companies, the necessary expertise was not there.
the IN-CTSI (Indiana-Clinical Translational Sciences Institute)
Nanoparticle size is an important criterion for our formulations and we routinely measure this with the Zetasizer Nano.
My students have always had great things to say about the Zetasizer Nano. They say it’s very easy to use. The software is very user-friendly and it can accommodate particles of various different sizes, so I have never had reason to evaluate another particle sizing instrument.
Dr. Albena Ivanisevic
Department of Materials Science and Engineering at North Carolina State University
On-line zeta potential measurement is helping us to achieve a more cost-efficient water facility.
Here at IU’s Nanocharacterization facility, the Malvern Zetasizer Nano is the ‘go to’ instrument for characterization of assembled product.
Dr Stella Aniagyei
Indiana University’s (IU) Molecular and Cellular Biochemistry Department
The big plus of an on-line instrument is real-time monitoring, the value of which was really brought home to us during a recent treatment event. The on-line data we collected during the event gave us new insight into a modified operating scheme that we’re now capitalizing on.
The images from the Morphologi G3 provided compelling evidence that the particles, rather than the sizing method, were a root cause of observed variability.
Reading Scientific Services Ltd
After just four months, the Morphologi G3-ID is already heavily used by researchers and students throughout the university. The automated microscopy and image analysis functions are especially popular and have saved countless hours compared with using manual microscopy techniques.
Southern Cross University
The [Zetasizer Nano] instrument is robust, easy to use and data acquisition is straightforward. It is as close to ‘student proof’ as it is possible to be!
Dr Krystelle Mafina
Queen Mary University
The technical support that we’ve received has been a deciding factor in our decision to continue to work with Malvern. Malvern systems also provide the cutting-edge performance and reliability that we need.
Domino Printing Sciences plc
The Morphologi G3-ID has proven straightforward and easy to use and we’ve already been successful in expanding our application of it into areas beyond construction materials.
Dr Ameneh Schneider
Association of the Austrian Cement Industry
The Zetasizer Nano has reliably delivered a substantial portion of data and continues to help drive our research.
As part of the multi-disciplinary lab at QMUL, materials and biomaterials research groups throughout the university, from engineers and chemists through to biologists and physicists, are benefiting from access to analysis using the Zetasizer Nano.
In a comparative assessment the Morphologi G3 delivered the perfect balance between speed of measurement, image resolution and price.
Dr. Robert Deffley
We’ve been running the Zetasizer APS continuously since 2012 and the real beauty is that we simply load the samples in multiwell plates, leave it to run, even overnight, and go back and pick up the results.
Dr Maria Håkansson
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