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Raman spectroscopy is an established spectroscopic technique for measuring the chemical identity and structure of materials across many industries, including pharmaceuticals, fine chemicals, minerals and foods.

Raman spectroscopy has a very high chemical specificity and is routinely used to differentiate between different polymorphs of the same compound for example. When used in conjunction with static image analysis it provides a powerful means of measuring the chemical identity of individually dispersed particles within a sample.

Applications of this technique include:

  • Chemically specific particle characterization of ingredients in mixtures
  • Identification of contaminants or outlier particles
  • Quantification of chemical composition in mixtures by particle count.

Related products

Morphologi G3-ID Automated measurement of particle size, shape and chemical identity. Image
Measurement
Particle shape, Particle size, Chemical identification
Particle size range
1µm to 1000µm
Technology
Image analysis, Raman spectroscopy
More information
Zetasizer Helix Characterize secondary and tertiary structure to develop mechanistic insight into oligomerization and aggregation. Image
Measurement
Protein aggregation, Zeta potential, Protein mobility, Molecular size, Molecular weight
Spectral performance
150cm-¹ to 1850cm-¹
Technology
Raman spectroscopy, Dynamic Light Scattering, Static Light Scattering, Electrophoretic Light Scattering
More information
 
 

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Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

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Characterization of protein aggregates in suspension and on a filter membrane by Morphologically-Directed Raman Spectroscopy Application Note (English)

The combination of static microscopy and Raman spectroscopy in the Morphologi G3-ID enables automated chemical identification of protein aggregates and other contaminants in a biotherapeutic sample, either in suspension via a thin-path wet cell or on...



Combined DLS/Raman provides New Molecular Insights of Complex Fluids Article (English)

In particular, this article demonstrates the correlation between molecular changes (Raman Spectroscopy) and microstructural evolution of rheological properties (DLS, DLS-optical microrheology) for the first time for surfactant-based wormlike micellar...



Discriminating between polymorphs of acetaminophen using Morphologically-Directed Raman Spectroscopy (MDRS) Application Note (English)

Polymorphic conversions are an ongoing problem in the pharmaceutical industry.  Here we describe the use of Morphologically-Directed Raman Spectroscopy to distinguish and quantify particles of different polymorphic types of acetaminophen (paracetamol...



Application of particle size analysis in Oral Solid Dose product formulation Webinar - Recorded (English)

The development of oral solid dose (OSD) products requires a knowledge of how the physical properties of the excipients and active pharmaceutical ingredients (APIs) present within a formulation affect product performance. This requires access to rele...

Product:
Morphologi range,Mastersizer range
Date recorded:
May 20 2015
Language:
English

Keywords: English Mastersizer range Particle size Laser diffraction Raman spectroscopy Webinar - Recorded Eastern Time Morphologi range 

Accelerating the Development of Generic Pharmaceuticals: Developing an Analytical Toolkit Suitable for De-formulating Complex Reference Products Article (English)

In its report ‘Critical Path Opportunities for Generic Drugs’, the FDA emphasizes the need for advances in the field of analytical sciences in order to accelerate the development of generic products. Here, Paul Kippax highlights techniques that are e...


Keywords: Development English Article Chemical identification Particle shape Particle size Gel Permeation Chromatography Image analysis Raman spectroscopy Size Exclusion Chromatography Pharmaceutical formulation and development Morphologi G3-ID 
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As part of the multi-disciplinary lab at QMUL, materials and biomaterials research groups throughout the university, from engineers and chemists through to biologists and physicists, are benefiting from access to analysis using the Zetasizer Nano.


Dr Krystelle Mafina, Queen Mary University, United Kingdom

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