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Raman spectroscopy is an established spectroscopic technique for measuring the chemical identity and structure of materials across many industries, including pharmaceuticals, fine chemicals, minerals and foods.

Raman spectroscopy has a very high chemical specificity and is routinely used to differentiate between different polymorphs of the same compound for example. When used in conjunction with static image analysis it provides a powerful means of measuring the chemical identity of individually dispersed particles within a sample.

Applications of this technique include:

  • Chemically specific particle characterization of ingredients in mixtures
  • Identification of contaminants or outlier particles
  • Quantification of chemical composition in mixtures by particle count.

Related products

Morphologi G3-ID Automated measurement of particle size, shape and chemical identity. Image
Measurement
Particle shape, Particle size, Chemical identification
Particle size range
1µm to 1000µm
Technology
Image analysis, Raman spectroscopy
More information
Zetasizer Helix Characterize secondary and tertiary structure to develop mechanistic insight into oligomerization and aggregation. Image
Measurement
Protein aggregation, Zeta potential, Protein mobility, Molecular size, Molecular weight
Spectral performance
150cm-¹ to 1850cm-¹
Technology
Raman spectroscopy, Dynamic Light Scattering, Static Light Scattering, Electrophoretic Light Scattering
More information
 
 

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Accelerating the deformulation workflow for oral solid dosage forms Whitepaper (English)

Oral Solid Dosage (OSD) forms still represent a significant share of the pharmaceutical market. As a result, they remain an important target for generic product developers. In this white paper we introduce a workflow for OSD product deformulation and...


Keywords: Development English Whitepaper Chemical identification Particle shape Particle size Image analysis Raman spectroscopy Pharmaceutical formulation and development Oral solid dose Morphologi G3-ID 

Novel analytical technologies for product deformulation - Part 3 Webinar - Recorded (English)

Deformulation of oral solid dose (OSD) products requires generic companies to determine the physical and chemical properties of the excipients and active pharmaceutical ingredients (APIs) present within the reference listed drug product (...

Product:
Morphologi G3-ID
Date recorded:
September 2 2014
Language:
English

Keywords: English Laser diffraction Raman spectroscopy Webinar - Recorded Eastern Time Pharmaceutical development Drug discovery Pharmaceutical formulation and development Morphologi G3-ID 

Novel analytical technologies for product deformulation - Part 2 Webinar - Recorded (English)

The development of generic dry powder inhaler products represents a significant challenge to product developers due to the complex interactions which occur between the formulation, device and patient during drug delivery. Regulatory guidance ...

Product:
Morphologi G3-ID,Mastersizer 3000
Date recorded:
August 19 2014
Language:
English

Keywords: English Mastersizer 3000 Laser diffraction Raman spectroscopy Webinar - Recorded Eastern Time Drug discovery Pharmaceutical chemical development Pharmaceutical formulation and development Morphologi G3-ID 

Pharmaceutical Excipient Characterization Application Note (English)

The aim of formulation development is to design a product and its manufacturing process to consistently deliver the intended Quality Target Product Profile (QTPP). This involves determining the Critical Quality Attributes (CQAs) for the Activ...


Keywords: QA/QC and routine testing Development Root cause analysis (troubleshooting) Powders and granules English Application Note Mastersizer range Chemical identification Particle shape Particle size Image analysis Laser diffraction Raman spectroscopy Pharmaceutical formulation and development Excipients and coatings Morphologi range 

Novel analytical technologies for product deformulation - Part 1 Webinar - Recorded (English)

Successful development of generic nasal drug products requires sponsors to understand how the dose is atomized by the chosen pump device in order to achieve bioequivalence. In addition, the impact of atomization of the particle size of the dr...

Date recorded:
August 5 2014
Language:
English

Keywords: English Particle size Raman spectroscopy Webinar - Recorded Eastern Time Pharmaceutical development Drug discovery Pharmaceutical formulation and development 
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