Skip to left navigation
Skip to page content
Resonant mass measurement is a technique used in an innovative way by Archimedes to detect and count sub visible and submicron particles in a sample, and to measure their size and mass and distributions of size and mass. At the heart of Archimedes is a MEMS (micro Electro-Mechanical Systems) sensor, containing a resonating cantilever with a microfluidic channel embedded in its surface. When a particle of between 50nm - 5µm flows through the fluidic channel, it alters the resonating frequency of the cantilever which indicates the buoyant mass, and also the dry mass and size of the particle.
The sensor is also able to provide information on sample concentration, viscosity, density, and volume, and can detect and measure both negatively and positively buoyant particles within a sample. The detection of positively buoyant particles is extremely useful, for example, to distinguish between protein aggregates and contaminating silicone oil droplets in a biopharmaceutical formulation.
The use of resonant mass measurement by the Archimedes offers the following advantages:
Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.
Resonant Mass Measurement technology covers a key size range of 50nm to 5µm for protein aggregation measurement. It requires less than 100µL of sample to give quantitative information on aggregate mass and count
Developing stable formulations of proteins is crucial to successful drug delivery, efficacy and lack of immunogenicity. SEC, DLS and Resonant Mass Measurement techniques provide valuable insight into a proteins behaviour in formulation
Archimedes is an innovative new benchtop instrument which detects and counts individual protein aggregates and other particles, and measures their mass and size down to 50µm by means of resonant mass measurement
Characterizing Biopharmaceutical Formulations using Archimedes
'Critical to Quality' measurements of protein aggregation in biopharmaceuticals
Use of Resonant Mass Measurement in biopharmaceutical development
All information supplied within is correct at time of publication.
Malvern Instruments pursues a policy of continual improvement due to technical development. We therefore reserve the right to deviate from information, descriptions, and specifications in this publication without notice. Malvern Instruments shall not be liable for errors contained herein or for incidental or consequential damages in connection with the furnishing, performance or use of this material.
Malvern and the 'hills' logo, Bohlin, Gemini, Insitec, ISys, Kinexus, Mastersizer, Morphologi, Rosand, SyNIRgi, Viscotek and Zetasizer, are International Trade Marks owned by Malvern Instruments Ltd.