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Resonant mass measurement is a technique used in an innovative way by Archimedes to detect and count sub visible and submicron particles in a sample, and to measure their size and mass and distributions of size and mass. At the heart of Archimedes is a MEMS (micro Electro-Mechanical Systems) sensor, containing a resonating cantilever with a microfluidic channel embedded in its surface. When a particle of between 50nm - 5µm flows through the fluidic channel, it alters the resonating frequency of the cantilever which indicates the buoyant mass, and also the dry mass and size of the particle.
The sensor is also able to provide information on sample concentration, viscosity, density, and volume, and can detect and measure both negatively and positively buoyant particles within a sample. The detection of positively buoyant particles is extremely useful, for example, to distinguish between protein aggregates and contaminating silicone oil droplets in a biopharmaceutical formulation.
The use of resonant mass measurement by the Archimedes offers the following advantages:
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Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...
Prefilled syringes are often used for packaging and delivery of therapeutic proteins. But the silicone oil lubricant can cause protein aggregation and promote adverse immunogenicity. In this presentation, data on these two topics will be summarized. ...
QBD is a term that is often spoken with respect to the production of biopharmaceuticals. However, despite the issuance of guidance documents on this topic, it is still relatively poorly understood.
This discussion seeks to demystify the concept ...
Esta es una plática introductoria general acerca del equipo de Archimedes. El objetivo es presentar el equipo, la técnica de medición que utiliza, cómo es que realiza la medición, que tipo de información podemos obtener, hablar sobre los límites de d...
Guest presenter - Prof. Dr. John Carpenter, University of Colorado
Counting and sizing of subvisible particles in therapeutic protein formulations are critically important activities for product development and quality assurance. Such characterizati...
(Webinar - Recorded)
Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products
(September 20 2016)
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