Skip to left navigation

Skip to page content

Find us on...

Resonant mass measurement is a technique used in an innovative way by Archimedes to detect and count sub visible and submicron particles in a sample, and to measure their size and mass and distributions of size and mass. At the heart of Archimedes is a MEMS (micro Electro-Mechanical Systems) sensor, containing a resonating cantilever with a microfluidic channel embedded in its surface. When a particle of between 50nm - 5µm flows through the fluidic channel, it alters the resonating frequency of the cantilever which indicates the buoyant mass, and also the dry mass and size of the particle.

The sensor is also able to provide information on sample concentration, viscosity, density, and volume, and can detect and measure both negatively and positively buoyant particles within a sample. The detection of positively buoyant particles is extremely useful, for example, to distinguish between protein aggregates and contaminating silicone oil droplets in a biopharmaceutical formulation.

The use of resonant mass measurement by the Archimedes offers the following advantages:

  • Quick, accurate, reproducible and reliable particle counting, and determination of particle mass and size in the 50nm - 5µm range.
  • Mass determination 350ag.
  • Little or no sample preparation required.
  • Minimal sample consumption (100µL).
  • High concentration (109 particles/mL).
  • High viscosity (100 cP).
  • Differentiation between positively and negatively buoyant particles.
  • Fast, NIST-traceable calibration.

Related products

Archimedes Particle Metrology System Image
Measurement
Particle size, Protein aggregation, Particle concentration
Particle size range
0.05µm to 5µm
Technology
Resonant mass measurement
More information
 
 

Resource center search

Free access to exclusive content including webinars, presentations, application notes, technical notes, whitepapers and more. Enter your search term in the box and use the drop down boxes to filter the results.

Reset filters
Items shown: 5, 10, 20, ALL
Sort by: Date or Alphabetical
Previous page Showing results 1 - 5 of 11 Next page
Characterize subvisible protein particles in formulations Webinar - Recorded (English)

Guest presenter - Prof. Dr. John Carpenter, University of Colorado Counting and sizing of subvisible particles in therapeutic protein formulations are critically important activities for product development and quality assurance. Such characterizati...

Product:
Archimedes
Date recorded:
March 25 2015
Language:
English

Keywords: English Webinar - Recorded Eastern Time Resonant mass measurement Protein aggregation Biopharmaceutical development Archimedes 

A fantastic voyage through the arena of nanoparticle drug delivery Webinar - Recorded (English)

The use of nanoparticles as drug delivery vehicles has seen a large amount of research and investment over the last decade as they have the potential for great benefits in the targeting and efficacy of drug treatments. The interest in them is largely...

Product:
Zetasizer Nano range,Archimedes,NanoSight range
Date recorded:
March 18 2015
Language:
English

Keywords: Nanoparticles English Particle concentration Particle size Zeta potential Dynamic Light Scattering Webinar - Recorded Eastern Time Zetasizer Nano range Resonant mass measurement Biological drug characterization and development Archimedes NanoSight range Nanoparticle Tracking Analysis 

Nanobubbles - separating the fact from fiction Webinar - Recorded (English)

Ultra-Fine (nano) bubbles have garnered increasing interest over the last few years as they open up the potential for improvements in a variety of applications from cleaning to agriculture. However they are still somewhat a mystery with respect to th...

Product:
Archimedes,Zetasizer Nano range,NanoSight range
Date recorded:
October 30 2014
Language:
English

Keywords: English Particle concentration Particle size Dynamic Light Scattering Webinar - Recorded Eastern Time Zetasizer Nano range Resonant mass measurement Archimedes NanoSight range Nanobubbles Nanoparticle Tracking Analysis 

Coriolis Pharma: Subvisible particle characterization by resonant mass measurement (Archimedes) during biopharmaceutical development Webinar - Recorded (English)

The characterization of subvisible particles is highly relevant for the development of biopharmaceuticals to ensure quality and safety of a therapy. The expectations by the authorities are increasing, which makes it necessary to include analytical me...

Product:
Archimedes
Date recorded:
September 16 2014
Language:
English

Keywords: English Particle concentration Particle size Sub-visible particles Webinar - Recorded Greenwich Time Resonant mass measurement Protein aggregation Proteins Bioformulation development Archimedes 

Differentiation and characterization of subvisible particulates in therapeutic protein products Application Note (English)

This application note provides an example of how Archimedes can be used to detect and quantify the formation of protein sub-visible particles and the introduction of silicone oil droplets, in response to shear stress.


Keywords: Contaminants and foreign particles English Application Note Resonant mass measurement Protein aggregation Proteins Biopharmaceutical development Archimedes 
Previous page Showing results 1 - 5 of 11 Next page

Glossary

Contact sales Register now