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Resonant mass measurement is a technique used in an innovative way by Archimedes to detect and count sub visible and submicron particles in a sample, and to measure their size and mass and distributions of size and mass. At the heart of Archimedes is a MEMS (micro Electro-Mechanical Systems) sensor, containing a resonating cantilever with a microfluidic channel embedded in its surface. When a particle of between 50nm - 5µm flows through the fluidic channel, it alters the resonating frequency of the cantilever which indicates the buoyant mass, and also the dry mass and size of the particle.

The sensor is also able to provide information on sample concentration, viscosity, density, and volume, and can detect and measure both negatively and positively buoyant particles within a sample. The detection of positively buoyant particles is extremely useful, for example, to distinguish between protein aggregates and contaminating silicone oil droplets in a biopharmaceutical formulation.

The use of resonant mass measurement by the Archimedes offers the following advantages:

  • Quick, accurate, reproducible and reliable particle counting, and determination of particle mass and size in the 50nm - 5µm range.
  • Mass determination 350ag.
  • Little or no sample preparation required.
  • Minimal sample consumption (100µL).
  • High concentration (109 particles/mL).
  • High viscosity (100 cP).
  • Differentiation between positively and negatively buoyant particles.
  • Fast, NIST-traceable calibration.

Related products

Archimedes Particle Metrology System Image
Measurement
Particle size, Protein aggregation, Particle concentration
Particle size range
0.05µm to 5µm
Technology
Resonant mass measurement
More information
 
 

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Applying complementary particle techniques for assessing comparability and biosimilarity of therapeutic products Webinar - Recorded (English)

Significant advances have been made in analytical technology for the characterization and identification of particles present in pharmaceutical products. With these advances comes a tremendous amount of new data with which to characterize biologics, ...

Product:
Archimedes,Zetasizer range,Viscotek SEC-MALS,Morphologi G3-ID,NanoSight range
Date recorded:
September 20 2016
Language:
English


Silicone oil-induced protein aggregation and immunogenicity Webinar - Recorded (English)

Prefilled syringes are often used for packaging and delivery of therapeutic proteins. But the silicone oil lubricant can cause protein aggregation and promote adverse immunogenicity. In this presentation, data on these two topics will be summarized. ...

Product:
Archimedes
Date recorded:
May 31 2016
Language:
English


Applying Quality by Design to the manufacture of drug product for biopharmaceuticals Webinar - Recorded (English)

QBD is a term that is often spoken with respect to the production of biopharmaceuticals.  However, despite the issuance of guidance documents on this topic, it is still relatively poorly understood.  This discussion seeks to demystify the concept ...

Product:
NanoSight range,Archimedes
Date recorded:
April 19 2016
Language:
English


Medición de Masa Resonante - Archimedes Webinar - Recorded (Spanish)

Esta es una plática introductoria general acerca del equipo de Archimedes. El objetivo es presentar el equipo, la técnica de medición que utiliza, cómo es que realiza la medición, que tipo de información podemos obtener, hablar sobre los límites de d...

Product:
Archimedes
Date recorded:
July 31 2015
Language:
Spanish


Characterize subvisible protein particles in formulations Webinar - Recorded (English)

Guest presenter - Prof. Dr. John Carpenter, University of Colorado Counting and sizing of subvisible particles in therapeutic protein formulations are critically important activities for product development and quality assurance. Such characterizati...

Product:
Archimedes
Date recorded:
March 25 2015
Language:
English

Keywords: English Webinar - Recorded Eastern Time Resonant mass measurement Protein aggregation Biopharmaceutical development Archimedes 
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