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Resonant mass measurement is a technique used in an innovative way by Archimedes to detect and count sub visible and submicron particles in a sample, and to measure their size and mass and distributions of size and mass. At the heart of Archimedes is a MEMS (micro Electro-Mechanical Systems) sensor, containing a resonating cantilever with a microfluidic channel embedded in its surface. When a particle of between 50nm - 5µm flows through the fluidic channel, it alters the resonating frequency of the cantilever which indicates the buoyant mass, and also the dry mass and size of the particle.
The sensor is also able to provide information on sample concentration, viscosity, density, and volume, and can detect and measure both negatively and positively buoyant particles within a sample. The detection of positively buoyant particles is extremely useful, for example, to distinguish between protein aggregates and contaminating silicone oil droplets in a biopharmaceutical formulation.
The use of resonant mass measurement by the Archimedes offers the following advantages:
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This application note provides an example of how Archimedes can be used to detect and quantify the formation of protein sub-visible particles and the introduction of silicone oil droplets, in response to shear stress.
Resonant Mass Measurement technology covers a key size range of 200nm to 5µm for protein aggregation measurement. It requires less than 100µL of sample to give quantitative information on aggregate mass and count
An introduction to Archimedes, the technique of resonant mass measurement, and how this technology is vital in understanding and monitoring early aggregation events in your biopharmaceutical formulation
Developing stable formulations of proteins is crucial to successful drug delivery, efficacy and lack of immunogenicity. SEC, DLS and Resonant Mass Measurement techniques provide valuable insight into a proteins behaviour in formulation
Archimedes is an innovative new benchtop instrument which detects and counts individual protein aggregates and other particles, and measures their mass and size down to 50µm by means of resonant mass measurement
(Webinar - Recorded)
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