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DNA/RNA and oligonucleotides
DNA/RNA and oligonucleotides characterization solutions
In the last decade research has intensified on the use of DNA, RNA, and shorter chain oligonucleotides as DNA vaccines or for gene therapy and delivery. Malvern technologies can help you in different aspects of the development by allowing you to:
- Determine the intrinsic viscosity to infer if the DNA plasmid is linear, coiled or super coiled (single/double-stranded, fragments).
- Quantitatively determine DNA to liposome ratios and determine success rate of encapsulation.
- Improve the delivery and half-life of DNA or oligonucleotides for transfection or gene therapy by optimizing their loading onto nanoparticles and liposomes.
- Measure molecular properties such as size, mass, and charge.
Malvern solutions for DNA/RNA and oligonucleotides
Analysis of plasmid DNA using SEC
Within the biopharmaceutical industry, recombinant plasmid DNAs are used as both raw materials and active ingredients in DNA vaccines. GSK is developing several...
Zeta potential and PCS measurements in gene therapy research
Gene therapy is the process by which genetic material is delivered, by means of a vector, to patients for a therapeutic purpose. Vectors are delivery vehicles...
