Crystalline structures are present in all classes of material including proteins, metals, and pharmaceuticals. If a substance exists in more than one crystal form then it is polymorphic. Different polymorphs can form due to changes in crystallization, temperature, processing or reaction time. Polymorphs can vary in their chemical, physical or material properties which can affect the quality, safety and efficacy of the final products. It is vital to be able to characterize and understand crystals and polymorphs of a substance in terms of particle size, shape and chemistry.

Malvern’s easy-to-use particle size, particle shape and chemical identification and rheology systems, combined with its industry and applications knowledge, can be used to help with characterization of polymorphs.

Applications include:

  • Optimization of crystallization process
  • Identify and qualify different polymorphs in mixtures
  • Identify critical to quality parameters

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