In the last decade research has intensified on the use of DNA, RNA, and shorter chain oligonucleotides as DNA vaccines or for gene therapy and delivery. Malvern technologies can help you in different aspects of the development by allowing you to:
- Determine the intrinsic viscosity to infer if the DNA plasmid is linear, coiled or super coiled (single/double-stranded, fragments).
- Quantitatively determine DNA to liposome ratios and determine success rate of encapsulation.
- Improve the delivery and half-life of DNA or oligonucleotides for transfection or gene therapy by optimizing their loading onto nanoparticles and liposomes.
- Measure molecular properties such as size, mass, and charge.