MicroCal PEAQ-DSC  microcalorimeters are powerful tools which enable characterization of the thermal stability of proteins and other biomolecules, primarily for biopharmaceutical development and manufacture. They are used for general stability studies, for biosimilarity and batch-to-batch comparability assessment, and for the optimization of purification and manufacturing conditions.  MicroCal PEAQ-DSC systems are simple to use, requiring little assay development, and no labelling or immobilization. 

There are two MicroCal PEAQ-DSC Differential Scanning Calorimetry instruments available, both of which are designed for use in the regulated biopharmaceutical environment.  The MicroCal PEAQ-DSC Automated system has an autosampler for hands-free operation, easing the workload of screening large numbers of samples. The MicroCal PEAQ-DSC is a manual instrument, which offers equal performance, reproducibility and minimal sample consumption, for laboratories which need to analyze fewer samples.  Both instruments are operated by MicroCal PEAQ-DSC software, containing the following four specialist modules:

  1. PEAQ-Compliance - for 21 CFR Part 11 compliant operation and data analysis
  2. PEAQ-Performance - to ensure optimal system operation 
  3. PEAQ-Smart (including PEAQ-Finder) - for SOP-based operation and automated analysis, and 
  4. PEAQ-Compare - for the direct comparison of DSC thermograms, between molecules and between batches

Supported products

MicroCal PEAQ-DSC Automated

Gold standard protein stability analysis for the regulated environment
Image
Measurement
Label-free analysis
Microcalorimetry - DELETED
Protein higher order structure - DELETED
Protein stability
Sample throughput
0per 24h day to 50per 24h day
Temperature range
2°C to 130°C
Technology
Differential Scanning Calorimetry

MicroCal PEAQ-DSC

Gold standard protein stability analysis for research applications
Image
Measurement
Label-free analysis
Microcalorimetry - DELETED
Protein higher order structure - DELETED
Protein stability
Sample throughput
0per 8h day to 6per 8h day
Temperature range
2°C to 130°C
Technology
Differential Scanning Calorimetry